{"id":"https://openalex.org/W2379594833","doi":"https://doi.org/10.1038/nature17995","title":"Local fitness landscape of the green fluorescent protein","display_name":"Local fitness landscape of the green fluorescent protein","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2379594833","doi":"https://doi.org/10.1038/nature17995","mag":"2379594833","pmid":"https://pubmed.ncbi.nlm.nih.gov/27193686"},"language":"en","primary_location":{"id":"doi:10.1038/nature17995","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature17995","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031580756","display_name":"Karen S. Sarkisyan","orcid":"https://orcid.org/0000-0002-5375-6341"},"institutions":[{"id":"https://openalex.org/I100051649","display_name":"Privolzhsky Research Medical University","ror":"https://ror.org/00apdsa62","country_code":"RU","type":"education","lineage":["https://openalex.org/I100051649"]},{"id":"https://openalex.org/I1310815967","display_name":"Central European Institute of Technology","ror":"https://ror.org/01p7k1986","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210090417","display_name":"Central European Institute of Technology \u2013 Masaryk University","ror":"https://ror.org/009nz6031","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967","https://openalex.org/I21449261","https://openalex.org/I4210090417"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["CZ","ES","RU"],"is_corresponding":true,"raw_author_name":"Karen S. Sarkisyan","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]},{"raw_affiliation_string":"Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","institution_ids":["https://openalex.org/I100051649"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060953538","display_name":"Dmitriy A. Bolotin","orcid":"https://orcid.org/0000-0002-8484-6067"},"institutions":[{"id":"https://openalex.org/I1310815967","display_name":"Central European Institute of Technology","ror":"https://ror.org/01p7k1986","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967"]},{"id":"https://openalex.org/I4210090417","display_name":"Central European Institute of Technology \u2013 Masaryk University","ror":"https://ror.org/009nz6031","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967","https://openalex.org/I21449261","https://openalex.org/I4210090417"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["CZ","RU"],"is_corresponding":false,"raw_author_name":"Dmitry A. Bolotin","raw_affiliation_strings":["Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042513673","display_name":"Margarita Meer","orcid":"https://orcid.org/0000-0001-8249-7097"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Margarita V. Meer","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023213065","display_name":"Dinara R. Usmanova","orcid":"https://orcid.org/0000-0001-5031-0013"},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES","RU"],"is_corresponding":false,"raw_author_name":"Dinara R. Usmanova","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Moscow Institute of Physics and Technology, Institutskiy Pereulok 9, g.Dolgoprudny 141700, Russia","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Moscow Institute of Physics and Technology, Institutskiy Pereulok 9, g.Dolgoprudny 141700, Russia","institution_ids":["https://openalex.org/I153845743"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042580739","display_name":"Alexander S. Mishin","orcid":"https://orcid.org/0000-0002-4935-7030"},"institutions":[{"id":"https://openalex.org/I100051649","display_name":"Privolzhsky Research Medical University","ror":"https://ror.org/00apdsa62","country_code":"RU","type":"education","lineage":["https://openalex.org/I100051649"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander S. Mishin","raw_affiliation_strings":["Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","institution_ids":["https://openalex.org/I100051649"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021300992","display_name":"\u0413. \u0412. \u0428\u0430\u0440\u043e\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0001-8610-5054"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210150146","display_name":"Moscow State University","ror":"https://ror.org/050a13t43","country_code":"TJ","type":"education","lineage":["https://openalex.org/I4210150146"]}],"countries":["RU","TJ"],"is_corresponding":false,"raw_author_name":"George V. Sharonov","raw_affiliation_strings":["Faculty of Medicine, Moscow State University, Lomonosov Avenue 31/5, Moscow 119192, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Moscow State University, Lomonosov Avenue 31/5, Moscow 119192, Russia","institution_ids":["https://openalex.org/I4210150146","https://openalex.org/I19880235"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028642432","display_name":"Dmitry N. Ivankov","orcid":"https://orcid.org/0000-0002-8224-4118"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES","RU"],"is_corresponding":false,"raw_author_name":"Dmitry N. Ivankov","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, 4 Institutskaya Str., Pushchino, Moscow Region 142290, Russia","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, 4 Institutskaya Str., Pushchino, Moscow Region 142290, Russia","institution_ids":["https://openalex.org/I4210137602"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065769732","display_name":"Nina G. Bozhanova","orcid":"https://orcid.org/0000-0002-2164-5698"},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nina G. Bozhanova","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000213515","display_name":"\u041c\u0438\u0445\u0430\u0438\u043b \u0421. \u0411\u0430\u0440\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-9339-7603"},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail S. Baranov","raw_affiliation_strings":["Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia","institution_ids":["https://openalex.org/I337778094"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039247486","display_name":"Onuralp S\u00f6ylemez","orcid":"https://orcid.org/0000-0001-8308-6855"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Onuralp Soylemez","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003443383","display_name":"Natalya S. Bogatyreva","orcid":"https://orcid.org/0000-0002-1719-1136"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES","RU"],"is_corresponding":false,"raw_author_name":"Natalya S. Bogatyreva","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, 4 Institutskaya Str., Pushchino, Moscow Region 142290, Russia","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, 4 Institutskaya Str., Pushchino, Moscow Region 142290, Russia","institution_ids":["https://openalex.org/I4210137602"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090105853","display_name":"Peter K. Vlasov","orcid":null},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Peter K. Vlasov","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061222540","display_name":"Evgeny S. Egorov","orcid":"https://orcid.org/0000-0002-6495-7173"},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny S. Egorov","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033657711","display_name":"Maria D. Logacheva","orcid":"https://orcid.org/0000-0002-8940-0400"},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210107660","display_name":"Institute for Information Transmission Problems","ror":"https://ror.org/013w2d378","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210107660"]},{"id":"https://openalex.org/I4210145583","display_name":"Bioengineering Center","ror":"https://ror.org/04f0ydx59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145583"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria D. Logacheva","raw_affiliation_strings":["A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127051, Russia","Department of Bioinformatics and Bioengineering, Moscow State University, Moscow 119234, Russia","Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia","Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow, 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127051, Russia","institution_ids":["https://openalex.org/I4210107660"]},{"raw_affiliation_string":"Department of Bioinformatics and Bioengineering, Moscow State University, Moscow 119234, Russia","institution_ids":["https://openalex.org/I4210145583"]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia","institution_ids":["https://openalex.org/I337778094"]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow, 117997, Russia","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023448826","display_name":"Alexey S. Kondrashov","orcid":"https://orcid.org/0000-0002-9193-3505"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210145583","display_name":"Bioengineering Center","ror":"https://ror.org/04f0ydx59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145583"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Alexey S. Kondrashov","raw_affiliation_strings":["Department of Bioinformatics and Bioengineering, Moscow State University, Moscow 119234, Russia","Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Bioinformatics and Bioengineering, Moscow State University, Moscow, 119234, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Bioengineering, Moscow State University, Moscow 119234, Russia","institution_ids":["https://openalex.org/I4210145583"]},{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Bioinformatics and Bioengineering, Moscow State University, Moscow, 119234, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060028352","display_name":"Dmitriy M. Chudakov","orcid":"https://orcid.org/0000-0003-0430-790X"},"institutions":[{"id":"https://openalex.org/I1310815967","display_name":"Central European Institute of Technology","ror":"https://ror.org/01p7k1986","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967"]},{"id":"https://openalex.org/I4210090417","display_name":"Central European Institute of Technology \u2013 Masaryk University","ror":"https://ror.org/009nz6031","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967","https://openalex.org/I21449261","https://openalex.org/I4210090417"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["CZ","RU"],"is_corresponding":false,"raw_author_name":"Dmitry M. Chudakov","raw_affiliation_strings":["Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012241793","display_name":"Ekaterina V. Putintseva","orcid":"https://orcid.org/0000-0003-4421-3844"},"institutions":[{"id":"https://openalex.org/I1310815967","display_name":"Central European Institute of Technology","ror":"https://ror.org/01p7k1986","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967"]},{"id":"https://openalex.org/I4210090417","display_name":"Central European Institute of Technology \u2013 Masaryk University","ror":"https://ror.org/009nz6031","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967","https://openalex.org/I21449261","https://openalex.org/I4210090417"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["CZ","RU"],"is_corresponding":false,"raw_author_name":"Ekaterina V. Putintseva","raw_affiliation_strings":["Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066151018","display_name":"Ilgar Z. Mamedov","orcid":"https://orcid.org/0000-0002-3992-9285"},"institutions":[{"id":"https://openalex.org/I1310815967","display_name":"Central European Institute of Technology","ror":"https://ror.org/01p7k1986","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967"]},{"id":"https://openalex.org/I4210090417","display_name":"Central European Institute of Technology \u2013 Masaryk University","ror":"https://ror.org/009nz6031","country_code":"CZ","type":"education","lineage":["https://openalex.org/I1310815967","https://openalex.org/I21449261","https://openalex.org/I4210090417"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["CZ","RU"],"is_corresponding":false,"raw_author_name":"Ilgar Z. Mamedov","raw_affiliation_strings":["Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Central European Institute of Technology, Masaryk University, Brno, 62500, Czech Republic","institution_ids":["https://openalex.org/I1310815967","https://openalex.org/I4210090417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022018631","display_name":"Dan S. Tawfik","orcid":"https://orcid.org/0000-0002-5914-8240"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dan S. Tawfik","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007827215","display_name":"Konstantin A. Lukyanov","orcid":"https://orcid.org/0000-0001-9845-2088"},"institutions":[{"id":"https://openalex.org/I100051649","display_name":"Privolzhsky Research Medical University","ror":"https://ror.org/00apdsa62","country_code":"RU","type":"education","lineage":["https://openalex.org/I100051649"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin A. Lukyanov","raw_affiliation_strings":["Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, Nizhny Novgorod, 603005, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, 603005 Nizhny Novgorod, Russia","institution_ids":["https://openalex.org/I100051649"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Nizhny Novgorod State Medical Academy, Minin Sq. 10/1, Nizhny Novgorod, 603005, Russia","institution_ids":["https://openalex.org/I100051649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072121403","display_name":"Fyodor A. Kondrashov","orcid":"https://orcid.org/0000-0001-8243-4694"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fyodor A. Kondrashov","raw_affiliation_strings":["Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), 23 Pg. Llu\u00eds Companys, 08010 Barcelona, Spain","Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), 23 Pg. Llu\u00eds Companys, 08010 Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 88 Dr. Aiguader, Barcelona, 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":21,"corresponding_author_ids":["https://openalex.org/A5031580756"],"corresponding_institution_ids":["https://openalex.org/I100051649","https://openalex.org/I1310815967","https://openalex.org/I170486558","https://openalex.org/I4210090417","https://openalex.org/I4210105571","https://openalex.org/I4210137962"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":40.5837,"has_fulltext":false,"cited_by_count":681,"citation_normalized_percentile":{"value":0.99825315,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"533","issue":"7603","first_page":"397","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.979200005531311,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9505000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.8235889077186584},{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.8186224102973938},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6408463716506958},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5390592813491821},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5115678906440735},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4846947491168976},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4359198212623596},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.31354209780693054}],"concepts":[{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.8235889077186584},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.8186224102973938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6408463716506958},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5390592813491821},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5115678906440735},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4846947491168976},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4359198212623596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31354209780693054},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037402","descriptor_name":"Hydrozoa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nature17995","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature17995","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:27193686","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27193686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:RePEc:nat:nature:v:533:y:2016:i:7603:d:10.1038_nature17995","is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature17995","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:europepmc.org:4045883","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4968632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.699999988079071,"display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1760278939","https://openalex.org/W1938986882","https://openalex.org/W1969012077","https://openalex.org/W1972595484","https://openalex.org/W1988625445","https://openalex.org/W1997116773","https://openalex.org/W2001348829","https://openalex.org/W2007325254","https://openalex.org/W2011343696","https://openalex.org/W2016427121","https://openalex.org/W2021928977","https://openalex.org/W2022449400","https://openalex.org/W2037332326","https://openalex.org/W2040374422","https://openalex.org/W2051603200","https://openalex.org/W2058393707","https://openalex.org/W2062210712","https://openalex.org/W2067361082","https://openalex.org/W2073171022","https://openalex.org/W2092189458","https://openalex.org/W2094223039","https://openalex.org/W2115645840","https://openalex.org/W2126015874","https://openalex.org/W2126643167","https://openalex.org/W2133609795","https://openalex.org/W2134757533","https://openalex.org/W2144893575","https://openalex.org/W2151887741","https://openalex.org/W2174114678"],"related_works":["https://openalex.org/W4225153397","https://openalex.org/W4295749382","https://openalex.org/W2952742538","https://openalex.org/W4301429967","https://openalex.org/W4304195508","https://openalex.org/W4302338605","https://openalex.org/W2337872996","https://openalex.org/W2950940317","https://openalex.org/W1968336705","https://openalex.org/W2953017728"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":81},{"year":2024,"cited_by_count":104},{"year":2023,"cited_by_count":110},{"year":2022,"cited_by_count":72},{"year":2021,"cited_by_count":80},{"year":2020,"cited_by_count":75},{"year":2019,"cited_by_count":50},{"year":2018,"cited_by_count":42},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":12}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}