{"id":"https://openalex.org/W2061111857","doi":"https://doi.org/10.1021/ci980140g","title":"Binary Quantitative Structure\u2212Activity Relationship (QSAR) Analysis of Estrogen Receptor Ligands","display_name":"Binary Quantitative Structure\u2212Activity Relationship (QSAR) Analysis of Estrogen Receptor Ligands","publication_year":1998,"publication_date":"1998-12-16","ids":{"openalex":"https://openalex.org/W2061111857","doi":"https://doi.org/10.1021/ci980140g","mag":"2061111857","pmid":"https://pubmed.ncbi.nlm.nih.gov/10094611"},"language":"en","primary_location":{"id":"doi:10.1021/ci980140g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci980140g","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013444907","display_name":"Hua Gao","orcid":"https://orcid.org/0000-0002-1326-6946"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hua Gao","raw_affiliation_strings":["Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195"],"affiliations":[{"raw_affiliation_string":"Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112084077","display_name":"Chris Williams","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Williams","raw_affiliation_strings":["Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195"],"affiliations":[{"raw_affiliation_string":"Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014765766","display_name":"Paul Labute","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Labute","raw_affiliation_strings":["Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195"],"affiliations":[{"raw_affiliation_string":"Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039926688","display_name":"J\u00fcrgen Bajorath","orcid":"https://orcid.org/0000-0002-0557-5714"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Bajorath","raw_affiliation_strings":["Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195"],"affiliations":[{"raw_affiliation_string":"Computational Chemistry and Informatics, MDS Panlabs, 11804 North Creek Parkway South, Bothell, Washington 98011, Chemical Computing Group Inc., 1255 University Street, Suite 1600, Montreal, Quebec, Canada H3B 3X3, and Department of Biological Structure, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013444907"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":5.3996,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.96272151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"1","first_page":"164","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.9770158529281616},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"Estrogen receptor","score":0.687822699546814},{"id":"https://openalex.org/keywords/training-set","display_name":"Training set","score":0.5642009377479553},{"id":"https://openalex.org/keywords/binding-affinities","display_name":"Binding affinities","score":0.5605127215385437},{"id":"https://openalex.org/keywords/estrogen","display_name":"Estrogen","score":0.5577674508094788},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5016028881072998},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4495663344860077},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4245336055755615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.22805657982826233},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.22253060340881348},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1775365173816681},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.14743179082870483},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1471630036830902},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11305767297744751},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10147956013679504},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.05344453454017639}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.9770158529281616},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.687822699546814},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.5642009377479553},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.5605127215385437},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5577674508094788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016028881072998},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4495663344860077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4245336055755615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22805657982826233},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22253060340881348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1775365173816681},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14743179082870483},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1471630036830902},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11305767297744751},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10147956013679504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05344453454017639},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci980140g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci980140g","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:10094611","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10094611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320316866","display_name":"Pomona College","ror":"https://ror.org/0074grg94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1855950477","https://openalex.org/W1984561564","https://openalex.org/W2005685204","https://openalex.org/W2007331274","https://openalex.org/W2017398555","https://openalex.org/W2031082832","https://openalex.org/W2042901562","https://openalex.org/W2046564413","https://openalex.org/W2063060349","https://openalex.org/W2071226001","https://openalex.org/W2073353512","https://openalex.org/W2099541593","https://openalex.org/W2116474322","https://openalex.org/W2503650069","https://openalex.org/W2766040292","https://openalex.org/W2950049799","https://openalex.org/W2951300526","https://openalex.org/W2952213121","https://openalex.org/W3154566661","https://openalex.org/W4250731271"],"related_works":["https://openalex.org/W200925908","https://openalex.org/W2040226249","https://openalex.org/W2012431882","https://openalex.org/W4210281470","https://openalex.org/W2083497194","https://openalex.org/W2061111857","https://openalex.org/W2032992521","https://openalex.org/W2032288499","https://openalex.org/W2136641116","https://openalex.org/W2035035284"],"abstract_inverted_index":{"The":[0,84,114],"use":[1],"of":[2,79,87,122,135],"high":[3],"throughput":[4],"screening":[5],"(HTS)":[6],"to":[7,70,118],"identify":[8],"lead":[9],"compounds":[10,27],"has":[11,54],"greatly":[12],"challenged":[13],"conventional":[14],"quantitative":[15,42],"structure-activity":[16],"relationship":[17],"(QSAR)":[18],"techniques":[19],"that":[20,38,75],"typically":[21],"correlate":[22,40],"structural":[23],"variations":[24],"in":[25,31,128],"similar":[26],"with":[28],"continuous":[29],"changes":[30],"biological":[32],"activity.":[33],"A":[34],"new":[35],"QSAR-like":[36],"methodology":[37],"can":[39],"less":[41],"assay":[43],"data":[44,96],"(i.e.,":[45],"\"active\"":[46],"versus":[47],"\"inactive\"),":[48],"as":[49,110],"initially":[50],"generated":[51],"by":[52],"HTS,":[53],"been":[55],"introduced.":[56],"In":[57],"the":[58,64,77,80,120,129],"present":[59],"study,":[60],"we":[61],"have,":[62],"for":[63],"first":[65],"time,":[66],"applied":[67,117],"this":[68],"approach":[69],"a":[71,94,99,111],"drug":[72],"discovery":[73],"problem;":[74],"is,":[76],"study":[78],"estrogen":[81,89,108,124],"receptor":[82],"ligands.":[83],"binding":[85],"affinities":[86],"463":[88],"analogues":[90,109,125],"were":[91],"transformed":[92],"into":[93],"binary":[95,101],"format,":[97],"and":[98],"predictive":[100],"QSAR":[102],"model":[103,115],"was":[104,116,137],"derived":[105],"using":[106],"410":[107],"training":[112,130],"set.":[113,131],"predict":[119],"activity":[121],"53":[123],"not":[126],"included":[127],"An":[132],"overall":[133],"accuracy":[134],"94%":[136],"obtained.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
