{"id":"https://openalex.org/W2952280638","doi":"https://doi.org/10.1021/ci960088t","title":"Managing the Combinatorial Explosion","display_name":"Managing the Combinatorial Explosion","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2952280638","doi":"https://doi.org/10.1021/ci960088t","mag":"2952280638"},"language":"en","primary_location":{"id":"doi:10.1021/ci960088t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci960088t","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011319169","display_name":"Burton A. Leland","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Burton A. Leland","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036193403","display_name":"Bradley D. Christie","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley D. Christie","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109935277","display_name":"James G. Nourse","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James G. Nourse","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083148352","display_name":"David L. Grier","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Grier","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067181616","display_name":"Raymond E. Carhart","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond E. Carhart","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016089173","display_name":"Tim Maffett","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Maffett","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071151729","display_name":"Steve M. Welford","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve M. Welford","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111785962","display_name":"Dennis H. Smith","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis H. Smith","raw_affiliation_strings":["MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577"],"affiliations":[{"raw_affiliation_string":"MDL Information Systems, Inc., 14600 Catalina St., San Leandro, California 94577","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5011319169"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7171,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.90219486,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"37","issue":"1","first_page":"62","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enumeration","display_name":"Enumeration","score":0.9043030738830566},{"id":"https://openalex.org/keywords/combinatorial-explosion","display_name":"Combinatorial explosion","score":0.8021150827407837},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6644828915596008},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.6262339949607849},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5876394510269165},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4348421096801758},{"id":"https://openalex.org/keywords/combinatorial-algorithms","display_name":"Combinatorial algorithms","score":0.4297385513782501},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.2509911060333252},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.23449978232383728},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17596164345741272},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.1535288393497467}],"concepts":[{"id":"https://openalex.org/C156340839","wikidata":"https://www.wikidata.org/wiki/Q2704791","display_name":"Enumeration","level":2,"score":0.9043030738830566},{"id":"https://openalex.org/C115908005","wikidata":"https://www.wikidata.org/wiki/Q2668364","display_name":"Combinatorial explosion","level":2,"score":0.8021150827407837},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6644828915596008},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6262339949607849},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5876394510269165},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4348421096801758},{"id":"https://openalex.org/C2988809283","wikidata":"https://www.wikidata.org/wiki/Q1514868","display_name":"Combinatorial algorithms","level":2,"score":0.4297385513782501},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.2509911060333252},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23449978232383728},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17596164345741272},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.1535288393497467},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ci960088t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci960088t","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2008734993","https://openalex.org/W2025410235","https://openalex.org/W2031415145","https://openalex.org/W2039492060","https://openalex.org/W2501722524"],"related_works":["https://openalex.org/W3012227109","https://openalex.org/W1488760143","https://openalex.org/W2776127089","https://openalex.org/W1968440743","https://openalex.org/W2758306115","https://openalex.org/W2058460798","https://openalex.org/W1490475243","https://openalex.org/W2115753827","https://openalex.org/W3005399847","https://openalex.org/W2974199725"],"abstract_inverted_index":{"Computer":[0],"software":[1,21],"designed":[2],"to":[3],"deal":[4],"with":[5],"the":[6,27],"large":[7],"amounts":[8],"of":[9,26,30,34],"data":[10],"generated":[11],"by":[12],"chemical":[13],"and":[14,36,39],"biological":[15],"research":[16],"programs":[17],"is":[18],"described.":[19],"The":[20],"includes":[22],"methods":[23],"for":[24],"representation":[25],"structural":[28],"components":[29],"combinatorial":[31,42],"libraries,":[32],"enumeration":[33],"structures":[35],"structure-based":[37],"searches,":[38],"comparisons":[40],"within":[41],"libraries.":[43]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}