{"id":"https://openalex.org/W2027392147","doi":"https://doi.org/10.1021/ci900254b","title":"Pharmacophore Modeling for Qualitative Prediction of Antiestrogenic Activity","display_name":"Pharmacophore Modeling for Qualitative Prediction of Antiestrogenic Activity","publication_year":2009,"publication_date":"2009-10-30","ids":{"openalex":"https://openalex.org/W2027392147","doi":"https://doi.org/10.1021/ci900254b","mag":"2027392147","pmid":"https://pubmed.ncbi.nlm.nih.gov/19877675"},"language":"en","primary_location":{"id":"doi:10.1021/ci900254b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci900254b","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060371306","display_name":"Simone Brogi","orcid":"https://orcid.org/0000-0001-9375-6242"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["GR","IT"],"is_corresponding":true,"raw_author_name":"Simone Brogi","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060459004","display_name":"Maria Kladi","orcid":null},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Maria Kladi","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109974680","display_name":"Constantinos Vagias","orcid":null},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Constantinos Vagias","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007637621","display_name":"Panagiota Papazafiri","orcid":"https://orcid.org/0000-0001-8388-4099"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Panagiota Papazafiri","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056599408","display_name":"Vassilios Roussis","orcid":"https://orcid.org/0000-0001-9856-4725"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Vassilios Roussis","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023303060","display_name":"Andrea Tafi","orcid":null},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["GR","IT"],"is_corresponding":false,"raw_author_name":"Andrea Tafi","raw_affiliation_strings":["Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece"],"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy, Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece, and Department of Animal & Human Physiology, School of Sciences, University of Athens, Panepistimiopolis Zografou, Athens 157 84, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060371306"],"corresponding_institution_ids":["https://openalex.org/I102064193","https://openalex.org/I200777214"],"apc_list":null,"apc_paid":null,"fwci":1.5044,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83579466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"49","issue":"11","first_page":"2489","last_page":"2497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.920799970626831,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.9106484651565552},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6929094791412354},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.522312343120575},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"Cytotoxicity","score":0.502650260925293},{"id":"https://openalex.org/keywords/lipinskis-rule-of-five","display_name":"Lipinski's rule of five","score":0.49298664927482605},{"id":"https://openalex.org/keywords/hydrogen-bond","display_name":"Hydrogen bond","score":0.43579578399658203},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.41451531648635864},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.4141392409801483},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.38868215680122375},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.2487902045249939},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1804881989955902},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.13539788126945496},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.1307087242603302},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07060596346855164}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.9106484651565552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6929094791412354},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.522312343120575},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.502650260925293},{"id":"https://openalex.org/C41847442","wikidata":"https://www.wikidata.org/wiki/Q916723","display_name":"Lipinski's rule of five","level":4,"score":0.49298664927482605},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.43579578399658203},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41451531648635864},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4141392409801483},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.38868215680122375},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2487902045249939},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1804881989955902},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.13539788126945496},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1307087242603302},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07060596346855164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ci900254b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci900254b","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:19877675","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19877675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/993319","is_oa":false,"landing_page_url":"http://pubs.acs.org/doi/pdfplus/10.1021/ci900254b","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/25609","is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/25609","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.6299999952316284,"display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W74826915","https://openalex.org/W1522872937","https://openalex.org/W1821437119","https://openalex.org/W1942063438","https://openalex.org/W1963837940","https://openalex.org/W1965527805","https://openalex.org/W1971570097","https://openalex.org/W1973191530","https://openalex.org/W1992098371","https://openalex.org/W2006902904","https://openalex.org/W2012802838","https://openalex.org/W2023172896","https://openalex.org/W2028394719","https://openalex.org/W2030115889","https://openalex.org/W2039658833","https://openalex.org/W2049507401","https://openalex.org/W2050456292","https://openalex.org/W2052464293","https://openalex.org/W2060011282","https://openalex.org/W2060298535","https://openalex.org/W2073764212","https://openalex.org/W2079979403","https://openalex.org/W2081240806","https://openalex.org/W2101738855","https://openalex.org/W2102548766","https://openalex.org/W2111650618","https://openalex.org/W2114918609","https://openalex.org/W2120064876","https://openalex.org/W2125624687","https://openalex.org/W2136926009","https://openalex.org/W2148824036","https://openalex.org/W2150232801","https://openalex.org/W4248107770"],"related_works":["https://openalex.org/W1984770684","https://openalex.org/W2058016544","https://openalex.org/W2328764986","https://openalex.org/W2128502140","https://openalex.org/W2094058003","https://openalex.org/W4390064787","https://openalex.org/W2028310680","https://openalex.org/W2030299803","https://openalex.org/W2060054864","https://openalex.org/W2072742549"],"abstract_inverted_index":{"A":[0],"ligand-based":[1],"pharmacophore":[2,32],"approach":[3],"for":[4,19],"the":[5,59,71,80,130,154,162],"prediction":[6],"of":[7,36,61,63,66,79,100,113,129,149,156],"antiestrogenic":[8],"activity":[9,112,135],"to":[10,104],"be":[11,105],"used":[12],"as":[13,107],"an":[14],"in":[15,96,118,153],"silico":[16],"screening":[17,78],"tool":[18],"bioactive":[20],"compounds":[21,115,132],"including":[22],"natural":[23],"products":[24],"was":[25,85,116],"developed":[26],"using":[27,120],"Catalyst":[28],"HypoGen.":[29],"The":[30,110],"generated":[31],"hypothesis":[33],"(HYPO-7)":[34],"consisted":[35],"five":[37],"features,":[38],"namely,":[39],"one":[40,47,52],"hydrophobic":[41,44],"(HY1),":[42],"two":[43],"aromatic":[45],"(HY2),":[46],"hydrogen-bond":[48,53],"acceptor":[49],"(HBA),":[50],"and":[51,141],"donor":[54],"(HBD).":[55],"HYPO-7":[56,89,150],"successfully":[57],"predicted":[58],"lack":[60],"cytotoxicity":[62],"a":[64,77,91,97],"number":[65],"new":[67,102],"metabolites":[68],"isolated":[69],"from":[70],"red":[72],"alga":[73],"Laurencia":[74],"glandulifera.":[75],"Furthermore,":[76],"Asinex":[81],"Gold":[82],"Collection":[83],"database":[84],"performed":[86],"by":[87],"coupling":[88],"with":[90,136],"docking":[92],"filtration,":[93],"which":[94],"resulted":[95],"restricted":[98],"set":[99],"12":[101],"scaffolds":[103],"investigated":[106],"potential":[108],"SERMs.":[109],"inhibitory":[111,134],"these":[114],"evaluated":[117],"vitro":[119],"MCF7":[121],"human":[122],"breast":[123],"adenocarcinoma":[124],"cell":[125],"line.":[126],"Ten":[127],"out":[128],"twelve":[131],"exhibited":[133],"IC(50)":[137],"values":[138],"between":[139],"26":[140],"188":[142],"microM.":[143],"This":[144],"result":[145],"shows":[146],"that":[147],"application":[148],"could":[151],"assist":[152],"selection":[155],"potentially":[157],"active":[158],"compounds,":[159],"thus":[160],"expediting":[161],"hit":[163],"discovery":[164],"process.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
