{"id":"https://openalex.org/W1989457560","doi":"https://doi.org/10.1021/ci900202d","title":"Secbase: Database Module To Retrieve Secondary Structure Elements with Ligand Binding Motifs","display_name":"Secbase: Database Module To Retrieve Secondary Structure Elements with Ligand Binding Motifs","publication_year":2009,"publication_date":"2009-10-07","ids":{"openalex":"https://openalex.org/W1989457560","doi":"https://doi.org/10.1021/ci900202d","mag":"1989457560","pmid":"https://pubmed.ncbi.nlm.nih.gov/19807134"},"language":"en","primary_location":{"id":"doi:10.1021/ci900202d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci900202d","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031181726","display_name":"Oliver Koch","orcid":"https://orcid.org/0000-0001-9228-217X"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Koch","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006929803","display_name":"Jason C. Cole","orcid":"https://orcid.org/0000-0002-0291-6317"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jason Cole","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018855544","display_name":"Peter C. Block","orcid":"https://orcid.org/0000-0002-7939-2849"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Block","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005420915","display_name":"G. Klebe","orcid":"https://orcid.org/0000-0002-4913-390X"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerhard Klebe","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Chemie, Philipps-Universit\u00e4t Marburg, Marbacher Weg 6, D-35032 Marburg, Germany, and The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, U.K","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005420915"],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":null,"apc_paid":null,"fwci":0.5478,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.65878461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"49","issue":"10","first_page":"2388","last_page":"2402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.6274067163467407},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank (RCSB PDB)","score":0.6067208051681519},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.563136100769043},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.5410609841346741},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5389742255210876},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.5024802684783936},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.44177180528640747},{"id":"https://openalex.org/keywords/carboxylate","display_name":"Carboxylate","score":0.4280655086040497},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.3999471366405487},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38414883613586426},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.38276493549346924},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1445903778076172},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08597704768180847}],"concepts":[{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.6274067163467407},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.6067208051681519},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.563136100769043},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5410609841346741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5389742255210876},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.5024802684783936},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.44177180528640747},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.4280655086040497},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3999471366405487},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38414883613586426},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38276493549346924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1445903778076172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08597704768180847},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci900202d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci900202d","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:19807134","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19807134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.7900000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1963550288","https://openalex.org/W1969460352","https://openalex.org/W1971251199","https://openalex.org/W1981575795","https://openalex.org/W1984640820","https://openalex.org/W1985744441","https://openalex.org/W1988129551","https://openalex.org/W1992562435","https://openalex.org/W2002125560","https://openalex.org/W2005277074","https://openalex.org/W2005635768","https://openalex.org/W2008708467","https://openalex.org/W2022383019","https://openalex.org/W2031168208","https://openalex.org/W2051628563","https://openalex.org/W2053721311","https://openalex.org/W2056852982","https://openalex.org/W2073745636","https://openalex.org/W2077895595","https://openalex.org/W2081525633","https://openalex.org/W2088878190","https://openalex.org/W2093595737","https://openalex.org/W2101298197","https://openalex.org/W2120138074","https://openalex.org/W2126374515","https://openalex.org/W2140992384","https://openalex.org/W2143070723","https://openalex.org/W2146642901","https://openalex.org/W2168211076","https://openalex.org/W2907227701","https://openalex.org/W3047703793"],"related_works":["https://openalex.org/W2732388178","https://openalex.org/W2017505838","https://openalex.org/W2728406523","https://openalex.org/W2731937419","https://openalex.org/W2045062364","https://openalex.org/W1979707045","https://openalex.org/W2270029940","https://openalex.org/W2584773272","https://openalex.org/W4353055924","https://openalex.org/W1999004357"],"abstract_inverted_index":{"Secbase":[0,108],"is":[1,54,80,141],"presented":[2],"as":[3,56,176,246],"a":[4,62,75,202,222],"novel":[5],"extension":[6],"module":[7],"of":[8,22,45,65,95,106,122,131,139,195,199,211,230,233,240],"Relibase.":[9,23],"It":[10],"integrates":[11],"the":[12,19,29,59,92,104,107,120,137,151,157,192,196,212,231,238],"information":[13,49],"about":[14,50],"secondary":[15,123,234],"structure":[16,124,194,235],"elements":[17,125,236],"into":[18,119],"retrieval":[20,36],"facilities":[21],"The":[24,47,186,209],"data":[25],"are":[26,113],"accessible":[27],"via":[28],"extended":[30,43],"Relibase":[31],"user":[32],"interface,":[33],"and":[34,52,74,97,256],"integrated":[35],"queries":[37],"can":[38],"be":[39],"addressed":[40],"using":[41],"an":[42,228],"version":[44],"Reliscript.":[46],"primary":[48],"alpha-helices":[51,200],"beta-sheets":[53],"used":[55],"provided":[57],"by":[58],"PDB.":[60],"Furthermore,":[61,227],"uniform":[63],"classification":[64,85],"all":[66],"turn":[67,84,198],"families,":[68],"based":[69,81],"on":[70,82,225],"recent":[71],"clustering":[72],"methods,":[73],"new":[76,117],"helix":[77,214],"assignment":[78],"that":[79,191],"this":[83],"has":[86],"been":[87],"included.":[88],"Algorithms":[89],"to":[90,136,143,164,217],"analyze":[91],"geometric":[93],"features":[94],"helices":[96,140],"beta-strands":[98],"were":[99],"also":[100,189],"implemented.":[101],"To":[102],"demonstrate":[103],"performance":[105],"implementation,":[109],"some":[110,241,249],"application":[111],"examples":[112],"given.":[114],"They":[115],"provide":[116,160],"insights":[118],"involvement":[121,146,232],"in":[126,147,178],"ligand":[127,148,167],"binding.":[128,149,226],"A":[129],"survey":[130],"water":[132],"molecules":[133],"detected":[134],"next":[135],"N-terminus":[138],"analyzed":[142],"show":[144],"their":[145],"Additionally,":[150],"parallel":[152],"oriented":[153],"NH":[154],"groups":[155,169],"at":[156],"alpha-helix":[158],"N-termini":[159],"special":[161],"binding":[162,254],"motifs":[163,255],"bind":[165],"particular":[166,253],"functional":[168],"with":[170,237],"two":[171],"adjacent":[172],"oxygen":[173],"atoms,":[174],"e.g.,":[175],"found":[177],"negatively":[179],"charged":[180,207],"carboxylate":[181],"or":[182,220],"phosphate":[183],"groups,":[184],"respectively.":[185],"present":[187],"study":[188],"shows":[190,248],"specific":[193],"first":[197],"provides":[201],"suitable":[203],"explanation":[204],"for":[205,252],"stabilizing":[206],"structures.":[208],"magnitude":[210],"overall":[213],"macrodipole":[215],"seems":[216],"have":[218],"no":[219],"only":[221],"minor":[223],"influence":[224],"overview":[229],"recognition":[239],"important":[242],"endogenous":[243],"ligands":[244],"such":[245],"cofactors":[247],"distinct":[250],"preference":[251],"amino":[257],"acids.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}