{"id":"https://openalex.org/W2007212378","doi":"https://doi.org/10.1021/ci8004429","title":"Interpretation of the Binding Affinities of PTP1B Inhibitors with the MM-GB/SA Method and the X-Score Scoring Function","display_name":"Interpretation of the Binding Affinities of PTP1B Inhibitors with the MM-GB/SA Method and the X-Score Scoring Function","publication_year":2009,"publication_date":"2009-03-25","ids":{"openalex":"https://openalex.org/W2007212378","doi":"https://doi.org/10.1021/ci8004429","mag":"2007212378","pmid":"https://pubmed.ncbi.nlm.nih.gov/19320460"},"language":"en","primary_location":{"id":"doi:10.1021/ci8004429","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci8004429","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046866779","display_name":"Xinglong Zhang","orcid":"https://orcid.org/0000-0003-1698-692X"},"institutions":[{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinglong Zhang","raw_affiliation_strings":["State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341859","display_name":"Xun Li","orcid":"https://orcid.org/0000-0002-6773-491X"},"institutions":[{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Li","raw_affiliation_strings":["State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016374232","display_name":"Renxiao Wang","orcid":"https://orcid.org/0000-0003-0485-0259"},"institutions":[{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renxiao Wang","raw_affiliation_strings":["State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioorganic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046866779"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112946"],"apc_list":null,"apc_paid":null,"fwci":1.7524,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.83651496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"49","issue":"4","first_page":"1033","last_page":"1048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/binding-affinities","display_name":"Binding affinities","score":0.6116816997528076},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5752997994422913},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5180809497833252},{"id":"https://openalex.org/keywords/moiety","display_name":"Moiety","score":0.5136722922325134},{"id":"https://openalex.org/keywords/affinities","display_name":"Affinities","score":0.5040637254714966},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.4750901758670807},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.43911564350128174},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.4137803912162781},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09212246537208557},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09088921546936035}],"concepts":[{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.6116816997528076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5752997994422913},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5180809497833252},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5136722922325134},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.5040637254714966},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4750901758670807},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.43911564350128174},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4137803912162781},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09212246537208557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09088921546936035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci8004429","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci8004429","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:19320460","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19320460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1483621455","https://openalex.org/W1567411871","https://openalex.org/W1592950931","https://openalex.org/W1830260748","https://openalex.org/W1963529746","https://openalex.org/W1970658820","https://openalex.org/W1972148009","https://openalex.org/W1973191530","https://openalex.org/W1975580333","https://openalex.org/W1976499671","https://openalex.org/W1977158130","https://openalex.org/W1983304433","https://openalex.org/W1985588649","https://openalex.org/W1993046136","https://openalex.org/W1995443944","https://openalex.org/W1999455459","https://openalex.org/W2002025649","https://openalex.org/W2009423060","https://openalex.org/W2012551774","https://openalex.org/W2014772558","https://openalex.org/W2018954741","https://openalex.org/W2019574809","https://openalex.org/W2020475659","https://openalex.org/W2030742611","https://openalex.org/W2032032407","https://openalex.org/W2032853185","https://openalex.org/W2037535298","https://openalex.org/W2039379511","https://openalex.org/W2039740672","https://openalex.org/W2042629507","https://openalex.org/W2043604722","https://openalex.org/W2050456292","https://openalex.org/W2051163038","https://openalex.org/W2063535987","https://openalex.org/W2067174909","https://openalex.org/W2067687494","https://openalex.org/W2072683434","https://openalex.org/W2075369230","https://openalex.org/W2081868968","https://openalex.org/W2091275803","https://openalex.org/W2092285329","https://openalex.org/W2092443343","https://openalex.org/W2096914244","https://openalex.org/W2106140689","https://openalex.org/W2107506448","https://openalex.org/W2112101018","https://openalex.org/W2114779636","https://openalex.org/W2116696124","https://openalex.org/W2127622220","https://openalex.org/W2128332459","https://openalex.org/W2134486592","https://openalex.org/W2134544924","https://openalex.org/W2142613992","https://openalex.org/W2142820798","https://openalex.org/W2145501578","https://openalex.org/W2158360182","https://openalex.org/W2158534713","https://openalex.org/W2160916136","https://openalex.org/W2174769933","https://openalex.org/W2515184929"],"related_works":["https://openalex.org/W3187200704","https://openalex.org/W2031259671","https://openalex.org/W3112966125","https://openalex.org/W2108080735","https://openalex.org/W1990832091","https://openalex.org/W2095596733","https://openalex.org/W4240532245","https://openalex.org/W4280649094","https://openalex.org/W1966443150","https://openalex.org/W1648190027"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,44,48,70,75,90,103,113,133,160,168,189,203],"binding":[4,91,108],"affinities":[5],"of":[6,9,23,37,64,94,121,128,132,179,182,205,208],"a":[7,27,59],"set":[8,181],"45":[10,96],"small-molecule":[11],"inhibitors":[12],"to":[13,58,88,126,141,151,202],"protein":[14],"tyrosine":[15],"phosphatase":[16],"1B":[17],"(PTP1B)":[18],"through":[19,172],"computational":[20,193],"approaches.":[21],"All":[22],"these":[24],"compounds":[25,183],"share":[26],"common":[28],"oxalylamino":[29],"benzoic":[30],"acid":[31],"(OBA)":[32],"moiety.":[33],"The":[34,99,119,145,176,192],"complex":[35,53,161],"structure":[36,54],"each":[38],"compound":[39],"was":[40,55,110,116,123,149],"modeled":[41],"by":[42,68,164],"using":[43,69],"GOLD":[45],"program":[46],"plus":[47],"ASP":[49],"scoring":[50,147],"function.":[51],"Each":[52],"then":[56],"subjected":[57],"molecular":[60,165],"dynamics":[61],"(MD)":[62],"simulation":[63],"2":[65],"ns":[66],"long":[67],"AMBER":[71],"program.":[72],"Based":[73],"on":[74,158,188],"configurational":[76,169],"ensembles":[77,170],"retrieved":[78],"from":[79],"MD":[80,174],"trajectories,":[81],"both":[82,159],"MM-GB/SA":[83,104,157],"and":[84,106,112,167],"MM-PB/SA":[85,122],"were":[86,136],"employed":[87],"compute":[89],"free":[92],"energies":[93],"all":[95],"PTP1B":[97,209],"inhibitors.":[98,210],"correlation":[100],"coefficient":[101],"between":[102],"results":[105,155],"experimental":[107],"data":[109],"0.87":[111],"standard":[114],"deviation":[115],"0.60":[117],"kcal/mol.":[118],"performance":[120],"slightly":[124],"inferior":[125],"that":[127],"MM-GB/SA.":[129],"Several":[130],"aspects":[131],"MM-GB(PB)/SA":[134],"method":[135],"explored":[137],"in":[138,196],"our":[139,197],"study":[140,198,204],"obtain":[142],"optimized":[143],"results.":[144,191],"X-Score":[146],"function":[148],"found":[150],"produce":[152],"equally":[153],"good":[154],"as":[156],"structures":[162],"prepared":[163],"docking":[166],"obtained":[171],"lengthy":[173],"simulations.":[175],"structure-activity":[177],"relationship":[178],"this":[180],"is":[184],"also":[185],"discussed":[186],"based":[187],"computed":[190],"approaches":[194],"validated":[195],"are":[199],"hopefully":[200],"applicable":[201],"other":[206],"classes":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}