{"id":"https://openalex.org/W2071008533","doi":"https://doi.org/10.1021/ci800231d","title":"ProSAR: A New Methodology for Combinatorial Library Design","display_name":"ProSAR: A New Methodology for Combinatorial Library Design","publication_year":2009,"publication_date":"2009-02-16","ids":{"openalex":"https://openalex.org/W2071008533","doi":"https://doi.org/10.1021/ci800231d","mag":"2071008533","pmid":"https://pubmed.ncbi.nlm.nih.gov/19434898"},"language":"en","primary_location":{"id":"doi:10.1021/ci800231d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci800231d","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100729955","display_name":"Hongming Chen","orcid":"https://orcid.org/0000-0002-4470-876X"},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Hongming Chen","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089259597","display_name":"Ulf B\u00f6rjesson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf B\u00f6rjesson","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076975589","display_name":"Ola Engkvist","orcid":"https://orcid.org/0000-0003-4970-6461"},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ola Engkvist","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031504624","display_name":"Thierry Kogej","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thierry Kogej","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031948426","display_name":"Mats Svensson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mats A. Svensson","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010916394","display_name":"Niklas Blomberg","orcid":"https://orcid.org/0000-0003-4155-5910"},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Niklas Blomberg","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023922853","display_name":"Dirk Weigelt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dirk Weigelt","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088068003","display_name":"Jeremy N. Burrows","orcid":"https://orcid.org/0000-0001-8448-6068"},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jeremy N. Burrows","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044116943","display_name":"Tim Lange","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tim Lange","raw_affiliation_strings":["DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden"],"affiliations":[{"raw_affiliation_string":"DECS GCS Computational Chemistry, AstraZeneca R&D M\u00f6lndal, Pepparedsleden 1, SE-43183 M\u00f6lndal, Sweden, and Medicinal Chemistry, AstraZeneca R&D S\u00f6dert\u00e4lje, SE-151 85 S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100729955"],"corresponding_institution_ids":["https://openalex.org/I4210143795"],"apc_list":null,"apc_paid":null,"fwci":2.0567,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.86608724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"49","issue":"3","first_page":"603","last_page":"614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13180","display_name":"Chemistry and Chemical Engineering","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9690999984741211,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.9238216876983643},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6199897527694702},{"id":"https://openalex.org/keywords/reagent","display_name":"Reagent","score":0.5710535645484924},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.5106871724128723},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2970961928367615},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.13558924198150635},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.0869600772857666}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.9238216876983643},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6199897527694702},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.5710535645484924},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5106871724128723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2970961928367615},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.13558924198150635},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0869600772857666}],"mesh":[{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci800231d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci800231d","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:19434898","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19434898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W82186612","https://openalex.org/W1557618397","https://openalex.org/W1966715677","https://openalex.org/W1975293246","https://openalex.org/W1976132885","https://openalex.org/W1978656711","https://openalex.org/W1978914444","https://openalex.org/W1981646692","https://openalex.org/W1984178377","https://openalex.org/W1985676669","https://openalex.org/W1991739064","https://openalex.org/W1998532396","https://openalex.org/W1999059618","https://openalex.org/W2007066266","https://openalex.org/W2011505858","https://openalex.org/W2011843431","https://openalex.org/W2013108712","https://openalex.org/W2013727775","https://openalex.org/W2017103045","https://openalex.org/W2019891559","https://openalex.org/W2033974703","https://openalex.org/W2035347370","https://openalex.org/W2050590316","https://openalex.org/W2064798225","https://openalex.org/W2066345214","https://openalex.org/W2077341638","https://openalex.org/W2079790786","https://openalex.org/W2083064918","https://openalex.org/W2090917557","https://openalex.org/W2108238592","https://openalex.org/W2113852446","https://openalex.org/W2119126379","https://openalex.org/W2134670392","https://openalex.org/W2153609134","https://openalex.org/W2156077095","https://openalex.org/W2222445509","https://openalex.org/W2614215910"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W42225299","https://openalex.org/W2943414817","https://openalex.org/W2197392606","https://openalex.org/W1605005150","https://openalex.org/W3184587995","https://openalex.org/W3092402433","https://openalex.org/W2716636539","https://openalex.org/W2902128418","https://openalex.org/W2385923153"],"abstract_inverted_index":{"A":[0],"method":[1],"is":[2,21,41,68,104,143],"introduced":[3],"for":[4,8,33,55,92,112],"performing":[5],"reagent":[6,19,35,126],"selection":[7,20],"chemical":[9],"library":[10,64,71,148],"design":[11,72,149],"based":[12,159],"on":[13,89],"topological":[14],"(2D)":[15],"pharmacophore":[16,31,127,184],"fingerprints.":[17],"Optimal":[18],"achieved":[22],"by":[23,70,98,156,172],"optimizing":[24],"the":[25,29,34,75,87,90,93,99,120,125,130,163,174],"Shannon":[26],"entropy":[27],"of":[28,86],"2D":[30],"distribution":[32],"set.":[36],"The":[37,81],"method,":[38],"termed":[39],"ProSAR,":[40],"therefore":[42],"expected":[43],"to":[44,107,145],"enumerate":[45],"compounds":[46,77,95],"that":[47,84,124,171],"could":[48],"serve":[49],"as":[50],"a":[51,57,138,146,157],"good":[52,183],"starting":[53],"point":[54],"deriving":[56],"structure":[58],"activity":[59],"relationship":[60],"(SAR)":[61],"in":[62,119],"combinatorial":[63],"design.":[65],"This":[66,102,141],"methodology":[67],"exemplified":[69],"examples":[73],"where":[74],"active":[76,94],"were":[78],"already":[79],"known.":[80],"results":[82,169],"show":[83,170],"most":[85],"pharmacophores":[88],"substituents":[91],"are":[96,134],"covered":[97],"designed":[100,155,180],"library.":[101],"strategy":[103,142,160],"further":[105],"expanded":[106],"include":[108],"product":[109,131,187],"property":[110,132,188],"profiles":[111],"aqueous":[113],"solubility,":[114],"hERG":[115],"risk":[116],"assessment,":[117],"etc.":[118],"optimization":[121],"process":[122],"so":[123],"diversity":[128,158],"and":[129,151,186],"profile":[133],"optimized":[135],"simultaneously":[136,182],"via":[137],"genetic":[139],"algorithm.":[140],"applied":[144],"two-dimensional":[147],"example":[150],"compared":[152],"with":[153,181],"libraries":[154,177],"which":[161],"minimizes":[162],"average":[164],"ensemble":[165],"Tanimoto":[166],"similarity.":[167],"Our":[168],"using":[173],"PSAR":[175],"methodology,":[176],"can":[178],"be":[179],"coverage":[185],"profile.":[189]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
