{"id":"https://openalex.org/W2137054391","doi":"https://doi.org/10.1021/ci7000814","title":"GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search","display_name":"GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2137054391","doi":"https://doi.org/10.1021/ci7000814","mag":"2137054391","pmid":"https://pubmed.ncbi.nlm.nih.gov/17580929"},"language":"en","primary_location":{"id":"doi:10.1021/ci7000814","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci7000814","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086901211","display_name":"Jian-Zhong Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian-Zhong Chen","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030","University of Pittsburgh"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317","https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643054","display_name":"Junmei Wang","orcid":"https://orcid.org/0000-0002-9607-8229"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmei Wang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317","https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028011485","display_name":"Xiang\u2010Qun Xie","orcid":"https://orcid.org/0000-0002-6881-6175"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang-Qun Xie","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030","University of Pittsburgh"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, Pittsburgh Molecular Library Screening Center, Drug Discovery Institute and Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5037, and Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317","https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086901211"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032","https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":3.092,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.92086517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"4","first_page":"1626","last_page":"1637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.7145262956619263},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.6774817109107971},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5103585124015808},{"id":"https://openalex.org/keywords/antagonist","display_name":"Antagonist","score":0.4339390695095062},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42579036951065063},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.30444541573524475},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2218334674835205},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16079086065292358},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.15147551894187927},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.1297268569469452},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11974546313285828}],"concepts":[{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.7145262956619263},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.6774817109107971},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5103585124015808},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4339390695095062},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42579036951065063},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.30444541573524475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2218334674835205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16079086065292358},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15147551894187927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1297268569469452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11974546313285828}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci7000814","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci7000814","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:17580929","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17580929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.411.9849","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.411.9849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cbio.ensmp.fr/~jvert/svn/bibli/local/Chen2007GPCR.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5799999833106995}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309549","display_name":"University of Houston","ror":"https://ror.org/040vwpm13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1605578858","https://openalex.org/W1974877767","https://openalex.org/W1978461481","https://openalex.org/W1979060714","https://openalex.org/W1986240377","https://openalex.org/W1990252792","https://openalex.org/W1998043623","https://openalex.org/W2010379115","https://openalex.org/W2013382945","https://openalex.org/W2021269933","https://openalex.org/W2043360059","https://openalex.org/W2050456292","https://openalex.org/W2059977407","https://openalex.org/W2066829425","https://openalex.org/W2071717945","https://openalex.org/W2074370108","https://openalex.org/W2100517022","https://openalex.org/W2110635658","https://openalex.org/W2114779636","https://openalex.org/W2127758174","https://openalex.org/W2132354058","https://openalex.org/W2133433899","https://openalex.org/W2133538755","https://openalex.org/W2146239303","https://openalex.org/W2149963584","https://openalex.org/W2150206249","https://openalex.org/W2155524113","https://openalex.org/W2157959080","https://openalex.org/W4292304406"],"related_works":["https://openalex.org/W1135792216","https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W2594726310","https://openalex.org/W2105416365","https://openalex.org/W2355193834","https://openalex.org/W1570378576","https://openalex.org/W1566559296","https://openalex.org/W2013003323","https://openalex.org/W1981076832"],"abstract_inverted_index":{"The":[0,135,168],"potential":[1,161,258],"for":[2,24,45,165,259],"therapeutic":[3],"specificity":[4],"in":[5,22,75,156,225,260],"regulating":[6],"diseases":[7],"has":[8],"made":[9],"cannabinoid":[10],"(CB)":[11],"receptors":[12],"one":[13],"of":[14,30,140,210,236],"the":[15,28,51,58,66,74,93,103,108,141,149,152,160,173,206,214,221,226,244,269],"most":[16],"important":[17],"G-protein-coupled":[18],"receptor":[19,97,114,153],"(GPCR)":[20],"targets":[21],"search":[23,44],"new":[25,253],"drugs.":[26],"Considering":[27],"lack":[29],"related":[31],"3D":[32,52,61,86,95,137,271],"experimental":[33],"structures,":[34],"we":[35,82],"have":[36,83],"established":[37,203,245],"a":[38,85,187,196,211,233,252,256],"structure-based":[39,247],"virtual":[40,248],"screening":[41,249],"protocol":[42],"to":[43,91,158,204],"CB2":[46,53,96,113,162,215,264,272],"bioactive":[47],"antagonists":[48,223],"based":[49,267],"on":[50,213,268],"homology":[54],"structure":[55,68,98,273],"model.":[56,274],"However,":[57],"existing":[59],"homology-predicted":[60],"models":[62],"often":[63],"deviate":[64],"from":[65,232],"native":[67],"and":[69,124,131,154,172,181],"therefore":[70],"may":[71],"incorrectly":[72],"bias":[73],"silico":[76,261],"design.":[77],"To":[78],"overcome":[79],"this":[80],"problem,":[81],"developed":[84],"testing":[87,188,227],"database":[88,190,228],"query":[89],"algorithm":[90,201],"examine":[92],"constructed":[94],"model":[99,116,139,171],"as":[100,102],"well":[101],"predicted":[104,174],"binding":[105,163,176,207],"pocket.":[106],"In":[107],"present":[109],"study,":[110],"an":[111],"antagonist-bound":[112],"complex":[115,143,170],"was":[117,144,202],"initially":[118],"generated":[119],"using":[120],"flexible":[121],"docking":[122,185],"simulation":[123],"then":[125,145],"further":[126,179],"optimized":[127],"by":[128,147,183],"molecular":[129],"dynamic":[130],"mechanical":[132],"(MD/MM)":[133],"calculations.":[134],"refined":[136],"structural":[138],"CB2-ligand":[142],"inspected":[146],"exploring":[148],"interactions":[150],"between":[151],"ligands":[155],"order":[157],"predict":[159],"pocket":[164],"its":[166],"antagonist.":[167],"ligand-receptor":[169],"antagonist":[175,265],"pockets":[177],"were":[178],"processed":[180],"validated":[182],"FlexX-Pharm":[184],"against":[186],"compound":[189],"that":[191,220,243],"contains":[192],"known":[193,222],"antagonists.":[194],"Furthermore,":[195],"consensus":[197],"scoring":[198],"(CScore)":[199],"function":[200],"rank":[205],"interaction":[208],"modes":[209],"ligand":[212],"receptor.":[216],"Our":[217,240],"results":[218],"indicated":[219],"seeded":[224],"can":[229],"be":[230],"distinguished":[231],"significant":[234],"amount":[235],"randomly":[237],"chosen":[238],"molecules.":[239],"studies":[241],"demonstrated":[242],"GPCR":[246],"approach":[250],"provided":[251],"strategy":[254],"with":[255],"high":[257],"identifying":[262],"novel":[263],"leads":[266],"homology-generated":[270]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
