{"id":"https://openalex.org/W2063199909","doi":"https://doi.org/10.1021/ci5006542","title":"CholMine: Determinants and Prediction of Cholesterol and Cholate Binding Across Nonhomologous Protein Structures","display_name":"CholMine: Determinants and Prediction of Cholesterol and Cholate Binding Across Nonhomologous Protein Structures","publication_year":2015,"publication_date":"2015-03-11","ids":{"openalex":"https://openalex.org/W2063199909","doi":"https://doi.org/10.1021/ci5006542","mag":"2063199909","pmid":"https://pubmed.ncbi.nlm.nih.gov/25760928"},"language":"en","primary_location":{"id":"doi:10.1021/ci5006542","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci5006542","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367555","display_name":"Nan Liu","orcid":"https://orcid.org/0000-0003-4102-2428"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Liu","raw_affiliation_strings":["Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000007335","display_name":"Jeffrey R. Van Voorst","orcid":null},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Van Voorst","raw_affiliation_strings":["Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103416274","display_name":"J. B. Johnston","orcid":null},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Johnston","raw_affiliation_strings":["Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029752062","display_name":"Leslie A. Kuhn","orcid":"https://orcid.org/0000-0001-9370-0978"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie A. Kuhn","raw_affiliation_strings":["Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, \u2021Department of Computer Science and Engineering, and \u00a7Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1319, United States","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029752062"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":1.0587,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79137655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"55","issue":"4","first_page":"747","last_page":"759"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"Cholesterol","score":0.5814342498779297},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5476675033569336},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.47009798884391785},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.438200980424881},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4282163679599762},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.39598673582077026},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38742777705192566},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38287195563316345},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3565024733543396}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5814342498779297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5476675033569336},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.47009798884391785},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.438200980424881},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4282163679599762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39598673582077026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38742777705192566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38287195563316345},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3565024733543396}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020355","descriptor_name":"Cholates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020355","descriptor_name":"Cholates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020355","descriptor_name":"Cholates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci5006542","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci5006542","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:25760928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25760928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309328","display_name":"Great Lakes Fishery Commission","ror":"https://ror.org/05sfwv538"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W45634013","https://openalex.org/W82875452","https://openalex.org/W1493642813","https://openalex.org/W1582743552","https://openalex.org/W1592720347","https://openalex.org/W1640072451","https://openalex.org/W1833104430","https://openalex.org/W1965796890","https://openalex.org/W1974499129","https://openalex.org/W1977219051","https://openalex.org/W1977467280","https://openalex.org/W1979166300","https://openalex.org/W1984061017","https://openalex.org/W1991149613","https://openalex.org/W1996497759","https://openalex.org/W2002203425","https://openalex.org/W2005320735","https://openalex.org/W2005323712","https://openalex.org/W2007395394","https://openalex.org/W2014922134","https://openalex.org/W2018414196","https://openalex.org/W2024062720","https://openalex.org/W2025594842","https://openalex.org/W2025993347","https://openalex.org/W2039399096","https://openalex.org/W2049848440","https://openalex.org/W2053916731","https://openalex.org/W2054167577","https://openalex.org/W2069888185","https://openalex.org/W2071661123","https://openalex.org/W2074473216","https://openalex.org/W2078167976","https://openalex.org/W2081606553","https://openalex.org/W2081912151","https://openalex.org/W2092508662","https://openalex.org/W2096418655","https://openalex.org/W2101581128","https://openalex.org/W2112153736","https://openalex.org/W2135472700","https://openalex.org/W2138551719","https://openalex.org/W2143927412","https://openalex.org/W2148972970","https://openalex.org/W2153153865","https://openalex.org/W2155909615","https://openalex.org/W2157957881","https://openalex.org/W2265157054","https://openalex.org/W2324719559","https://openalex.org/W4239340399","https://openalex.org/W4240497236","https://openalex.org/W4247605598"],"related_works":["https://openalex.org/W1570348606","https://openalex.org/W2073626691","https://openalex.org/W2097544532","https://openalex.org/W1973479917","https://openalex.org/W2337329154","https://openalex.org/W2951275810","https://openalex.org/W2462655579","https://openalex.org/W2328917962","https://openalex.org/W2733723768","https://openalex.org/W2287683639"],"abstract_inverted_index":{"Identifying":[0],"physiological":[1],"ligands":[2],"is":[3],"necessary":[4],"for":[5,122,138],"annotating":[6],"new":[7],"protein":[8,35,143],"structures,":[9,101],"yet":[10],"this":[11],"presents":[12],"a":[13,24,84],"significant":[14],"challenge":[15],"to":[16,59,91,105],"biologists":[17],"and":[18,28,80,108,113,136,146],"pharmaceutical":[19],"chemists.":[20],"Here":[21],"we":[22],"develop":[23],"predictor":[25,66],"of":[26,51,120,133],"cholesterol":[27,68],"cholate":[29],"binding":[30,111,121],"that":[31],"works":[32],"across":[33],"diverse":[34],"families,":[36],"extending":[37],"beyond":[38],"sequence":[39],"motif-based":[40],"prediction.":[41],"This":[42],"approach":[43],"combines":[44],"SimSite3D":[45],"site":[46],"comparison":[47],"with":[48,70,83],"the":[49,110,118,131],"detection":[50],"conserved":[52],"interactions":[53],"in":[54,77,130],"cholesterol/cholate":[55],"bound":[56],"crystal":[57],"structures":[58],"define":[60],"three-dimensional":[61],"interaction":[62],"motifs.":[63],"The":[64,94],"resulting":[65],"identifies":[67],"sites":[69],"an":[71],"\u223c82%":[72],"unbiased":[73],"true":[74],"positive":[75,88],"rate":[76,89],"both":[78],"membrane":[79],"soluble":[81],"proteins,":[82],"very":[85],"low":[86],"false":[87],"relative":[90],"other":[92],"predictors.":[93],"CholMine":[95,126],"Web":[96],"server":[97],"can":[98],"analyze":[99],"users'":[100],"detect":[102],"those":[103],"likely":[104],"bind":[106],"cholesterol/cholate,":[107],"predict":[109],"mode":[112],"key":[114],"interactions.":[115],"By":[116],"deciphering":[117],"determinants":[119],"these":[123],"important":[124],"steroids,":[125],"may":[127],"also":[128],"aid":[129],"design":[132],"selective":[134],"inhibitors":[135],"detergents":[137],"targets":[139],"such":[140],"as":[141],"G":[142],"coupled":[144],"receptors":[145],"bile":[147],"acid":[148],"receptors.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}
