{"id":"https://openalex.org/W2023327385","doi":"https://doi.org/10.1021/ci500624s","title":"Pocketome of Human Kinases: Prioritizing the ATP Binding Sites of (Yet) Untapped Protein Kinases for Drug Discovery","display_name":"Pocketome of Human Kinases: Prioritizing the ATP Binding Sites of (Yet) Untapped Protein Kinases for Drug Discovery","publication_year":2014,"publication_date":"2014-12-31","ids":{"openalex":"https://openalex.org/W2023327385","doi":"https://doi.org/10.1021/ci500624s","mag":"2023327385","pmid":"https://pubmed.ncbi.nlm.nih.gov/25557645"},"language":"en","primary_location":{"id":"doi:10.1021/ci500624s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500624s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057416678","display_name":"Andrea Volkamer","orcid":"https://orcid.org/0000-0002-3760-580X"},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X Institute","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Volkamer","raw_affiliation_strings":["BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052805675","display_name":"Sameh Eid","orcid":"https://orcid.org/0000-0002-4689-6354"},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X Institute","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sameh Eid","raw_affiliation_strings":["BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samo Turk","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X Institute","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Samo Turk","raw_affiliation_strings":["BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058097371","display_name":"Sabrina Jaeger-Honz","orcid":"https://orcid.org/0000-0003-1144-7468"},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X Institute","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabrina Jaeger","raw_affiliation_strings":["BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013173045","display_name":"Friedrich Rippmann","orcid":"https://orcid.org/0000-0002-4604-9251"},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich Rippmann","raw_affiliation_strings":["Global\rComputational Chemistry, Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global\rComputational Chemistry, Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051191427","display_name":"Simone Fulle","orcid":"https://orcid.org/0000-0002-7646-5889"},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X Institute","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone Fulle","raw_affiliation_strings":["BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2415,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.9677003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"55","issue":"3","first_page":"538","last_page":"549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinome","display_name":"Kinome","score":0.9957712888717651},{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.9392554759979248},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.7701858878135681},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.7272564172744751},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6511044502258301},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4455578029155731},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.322005033493042},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.26354390382766724},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10123652219772339}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.9957712888717651},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9392554759979248},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7701858878135681},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7272564172744751},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6511044502258301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4455578029155731},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.322005033493042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26354390382766724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10123652219772339}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci500624s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500624s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:25557645","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25557645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1589851298","https://openalex.org/W1970799005","https://openalex.org/W1974899413","https://openalex.org/W1975436091","https://openalex.org/W1975875968","https://openalex.org/W1981064967","https://openalex.org/W1986191025","https://openalex.org/W1991231915","https://openalex.org/W1993452864","https://openalex.org/W1999287489","https://openalex.org/W2005190047","https://openalex.org/W2011032913","https://openalex.org/W2015631955","https://openalex.org/W2018408116","https://openalex.org/W2019971393","https://openalex.org/W2023568503","https://openalex.org/W2028561673","https://openalex.org/W2030205108","https://openalex.org/W2030753552","https://openalex.org/W2031966640","https://openalex.org/W2042553090","https://openalex.org/W2043509228","https://openalex.org/W2050972073","https://openalex.org/W2052314111","https://openalex.org/W2055043387","https://openalex.org/W2056399835","https://openalex.org/W2067234168","https://openalex.org/W2074631079","https://openalex.org/W2076900316","https://openalex.org/W2077804275","https://openalex.org/W2077953804","https://openalex.org/W2079953901","https://openalex.org/W2082425789","https://openalex.org/W2088933990","https://openalex.org/W2096541451","https://openalex.org/W2100772783","https://openalex.org/W2101220662","https://openalex.org/W2102140136","https://openalex.org/W2107972068","https://openalex.org/W2109321699","https://openalex.org/W2119380188","https://openalex.org/W2125566651","https://openalex.org/W2127084978","https://openalex.org/W2128058093","https://openalex.org/W2130479394","https://openalex.org/W2131978327","https://openalex.org/W2133725039","https://openalex.org/W2137015675","https://openalex.org/W2154714625","https://openalex.org/W2164088236","https://openalex.org/W2165509651","https://openalex.org/W2165575701","https://openalex.org/W2342249984","https://openalex.org/W2414636706","https://openalex.org/W2479224456","https://openalex.org/W4210799517","https://openalex.org/W4238448376","https://openalex.org/W4247554111"],"related_works":["https://openalex.org/W3000739705","https://openalex.org/W2974949722","https://openalex.org/W2023327385","https://openalex.org/W2156130452","https://openalex.org/W3193289893","https://openalex.org/W1553731660","https://openalex.org/W3121492875","https://openalex.org/W2009500663","https://openalex.org/W2991424847","https://openalex.org/W2925167008"],"abstract_inverted_index":{"Protein":[0],"kinases":[1,33,185,228,240],"are":[2,63,177,187],"involved":[3],"in":[4,26,38,102,108,127,178],"a":[5,23,29,55,90],"variety":[6],"of":[7,18,32,46,58,68,93,97,141,153,162,174,190,212,216,226],"diseases":[8],"including":[9],"cancer,":[10],"inflammation,":[11],"and":[12,44,132,150,157],"autoimmune":[13],"disorders.":[14],"Although":[15],"the":[16,69,78,94,98,103,128,138,142,154,160,175,210,217,233],"development":[17],"new":[19,207],"kinase":[20,61,113,123,164],"inhibitors":[21],"is":[22,48,106],"major":[24],"focus":[25],"pharmaceutical":[27],"research,":[28],"large":[30,73],"number":[31],"remained":[34],"so":[35,198,237],"far":[36,199,238],"unexplored":[37],"drug":[39,116,242],"discovery":[40,117,243],"projects.":[41,118],"The":[42,168,203],"selection":[43,80],"assessment":[45,225],"targets":[47,189],"an":[49],"essential":[50],"but":[51,194],"challenging":[52],"area.":[53],"Today,":[54],"few":[56],"thousands":[57],"experimentally":[59],"determined":[60],"structures":[62,114,125,183],"available,":[64],"covering":[65],"about":[66,172],"half":[67],"human":[70,100,122],"kinome.":[71,143,219],"This":[72],"structural":[74],"source":[75],"allows":[76],"guiding":[77],"target":[79],"via":[81],"structure-based":[82],"druggability":[83,211,224],"prediction":[84],"approaches":[85],"such":[86],"as":[87],"DoGSiteScorer.":[88],"Here,":[89],"thorough":[91],"analysis":[92,205],"ATP":[95,155,213],"pockets":[96,156,215],"entire":[99,218],"kinome":[101,176],"DFG-in":[104],"state":[105],"presented":[107,204],"order":[109],"to":[110,147,158,165,197,229,235],"prioritize":[111,236],"novel":[112],"for":[115,137,232,241],"For":[119],"this,":[120],"all":[121],"X-ray":[124],"available":[126],"PDB":[129],"were":[130,135],"collected,":[131],"homology":[133],"models":[134],"generated":[136],"missing":[139],"part":[140],"DoGSiteScorer":[144],"was":[145],"used":[146],"calculate":[148],"geometrical":[149],"physicochemical":[151],"properties":[152],"predict":[159],"potential":[161],"each":[163],"be":[166,230],"druggable.":[167,180],"results":[169],"indicate":[170],"that":[171,186],"75%":[173],"principle":[179],"Top":[181],"ranking":[182],"comprise":[184],"primary":[188],"known":[191],"approved":[192],"drugs":[193],"additionally":[195],"point":[196],"less":[200],"explored":[201],"kinases.":[202],"provides":[206],"insights":[208],"into":[209],"binding":[214],"We":[220],"anticipate":[221],"this":[222],"comprehensive":[223],"protein":[227],"helpful":[231],"community":[234],"untapped":[239],"efforts.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
