{"id":"https://openalex.org/W2007040059","doi":"https://doi.org/10.1021/ci500537e","title":"(\u2212) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor \u03b2","display_name":"(\u2212) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor \u03b2","publication_year":2014,"publication_date":"2014-11-10","ids":{"openalex":"https://openalex.org/W2007040059","doi":"https://doi.org/10.1021/ci500537e","mag":"2007040059","pmid":"https://pubmed.ncbi.nlm.nih.gov/25383984"},"language":"en","primary_location":{"id":"doi:10.1021/ci500537e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ci500537e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ci500537e","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/ci500537e","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038621910","display_name":"Ifedayo Victor Ogungbe","orcid":"https://orcid.org/0000-0002-8048-5137"},"institutions":[{"id":"https://openalex.org/I61937129","display_name":"Jackson State University","ror":"https://ror.org/01ecnnp60","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I61937129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ifedayo Victor Ogungbe","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States","institution_ids":["https://openalex.org/I61937129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075350320","display_name":"Rebecca A. Crouch","orcid":null},"institutions":[{"id":"https://openalex.org/I61937129","display_name":"Jackson State University","ror":"https://ror.org/01ecnnp60","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I61937129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Crouch","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States","institution_ids":["https://openalex.org/I61937129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075748737","display_name":"Teresa Demeritte","orcid":null},"institutions":[{"id":"https://openalex.org/I61937129","display_name":"Jackson State University","ror":"https://ror.org/01ecnnp60","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I61937129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Demeritte","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States","institution_ids":["https://openalex.org/I61937129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038621910"],"corresponding_institution_ids":["https://openalex.org/I61937129"],"apc_list":null,"apc_paid":null,"fwci":0.1426,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.53408025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"54","issue":"11","first_page":"3051","last_page":"3055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pinoresinol","display_name":"Pinoresinol","score":0.6258941888809204},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5901528596878052},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"Thyroid hormone receptor","score":0.5705816149711609},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5559605360031128},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5189720988273621},{"id":"https://openalex.org/keywords/hormone-receptor","display_name":"Hormone receptor","score":0.4983482360839844},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.445564866065979},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.42961305379867554},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.42758485674858093},{"id":"https://openalex.org/keywords/thyroid","display_name":"Thyroid","score":0.42599067091941833},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3636385202407837},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3466121554374695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.246104896068573},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2067432403564453},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19901642203330994},{"id":"https://openalex.org/keywords/lignan","display_name":"Lignan","score":0.1902647316455841},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.18066784739494324},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.08388400077819824}],"concepts":[{"id":"https://openalex.org/C2778193312","wikidata":"https://www.wikidata.org/wiki/Q3388802","display_name":"Pinoresinol","level":3,"score":0.6258941888809204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5901528596878052},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.5705816149711609},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5559605360031128},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5189720988273621},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4983482360839844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.445564866065979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42961305379867554},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42758485674858093},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.42599067091941833},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3636385202407837},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3466121554374695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.246104896068573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2067432403564453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19901642203330994},{"id":"https://openalex.org/C2781264555","wikidata":"https://www.wikidata.org/wiki/Q424634","display_name":"Lignan","level":2,"score":0.1902647316455841},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18066784739494324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08388400077819824},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ci500537e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ci500537e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ci500537e","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:25383984","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25383984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.809.9469","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.809.9469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/50/5f/ci500537e.PMC4245177.pdf","raw_type":"text"},{"id":"pmh:oai:europepmc.org:3611927","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4245177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/ci500537e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ci500537e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ci500537e","source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"publisher-specific-oa","license_id":"https://openalex.org/licenses/publisher-specific-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5315200950","display_name":null,"funder_award_id":"5R25GM067122-08","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6620735412","display_name":null,"funder_award_id":"5G12MD007581-17","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G7314163092","display_name":null,"funder_award_id":"EPS-0903787","funder_id":"https://openalex.org/F4320338283","funder_display_name":"Office of Experimental Program to Stimulate Competitive Research"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320338283","display_name":"Office of Experimental Program to Stimulate Competitive Research","ror":"https://ror.org/04k9mqs78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007040059.pdf","grobid_xml":"https://content.openalex.org/works/W2007040059.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W625272620","https://openalex.org/W1975972697","https://openalex.org/W1976140173","https://openalex.org/W1991425311","https://openalex.org/W1994969488","https://openalex.org/W2019883194","https://openalex.org/W2034035358","https://openalex.org/W2036457457","https://openalex.org/W2043855224","https://openalex.org/W2044690397","https://openalex.org/W2058683100","https://openalex.org/W2059379238","https://openalex.org/W2072977569","https://openalex.org/W2074714625","https://openalex.org/W2100190412","https://openalex.org/W2100614131","https://openalex.org/W2114918609","https://openalex.org/W2162177596","https://openalex.org/W2167152104","https://openalex.org/W2169486907","https://openalex.org/W2315525964","https://openalex.org/W2332383213"],"related_works":["https://openalex.org/W47568158","https://openalex.org/W2153888636","https://openalex.org/W2037961015","https://openalex.org/W4236980160","https://openalex.org/W49660309","https://openalex.org/W4241869599","https://openalex.org/W4240468112","https://openalex.org/W2084938642","https://openalex.org/W3217698937","https://openalex.org/W2098808668"],"abstract_inverted_index":{"Lignans":[0],"are":[1,12,59],"important":[2,80],"biologically":[3],"active":[4],"dietary":[5],"polyphenolic":[6],"compounds.":[7],"Consumption":[8],"of":[9,30,61,84],"foods":[10],"that":[11,35,52],"rich":[13],"in":[14],"lignans":[15,36,53],"is":[16],"associated":[17],"with":[18],"positive":[19],"health":[20],"effects.":[21],"Using":[22],"modeling":[23],"tools":[24],"to":[25],"probe":[26],"the":[27,42,62,76,85],"ligand-binding":[28],"pockets":[29],"molecular":[31],"receptors,":[32],"we":[33],"found":[34],"have":[37],"high":[38],"docking":[39],"affinity":[40],"for":[41],"human":[43,63],"thyroid":[44,64],"hormone":[45,65],"receptor":[46,66],"\u03b2.":[47,67],"Follow-up":[48],"experimental":[49],"results":[50],"show":[51,71],"(-)":[54],"arctigenin":[55],"and":[56,79],"(+)":[57],"pinoresinol":[58],"antagonists":[60],"The":[68],"modeled":[69],"complexes":[70],"key":[72],"plausible":[73],"interactions":[74],"between":[75],"two":[77],"ligands":[78],"amino":[81],"acid":[82],"residues":[83],"receptor.":[86]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}