{"id":"https://openalex.org/W2018745394","doi":"https://doi.org/10.1021/ci500487q","title":"Which Three-Dimensional Characteristics Make Efficient Inhibitors of Protein\u2013Protein Interactions?","display_name":"Which Three-Dimensional Characteristics Make Efficient Inhibitors of Protein\u2013Protein Interactions?","publication_year":2014,"publication_date":"2014-10-06","ids":{"openalex":"https://openalex.org/W2018745394","doi":"https://doi.org/10.1021/ci500487q","mag":"2018745394","pmid":"https://pubmed.ncbi.nlm.nih.gov/25285479"},"language":"en","primary_location":{"id":"doi:10.1021/ci500487q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500487q","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078099175","display_name":"M\u00e9laine A. Kuenemann","orcid":"https://orcid.org/0000-0001-5317-2111"},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M\u00e9laine A. Kuenemann","raw_affiliation_strings":["Inserm, U973, Paris 75013, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France"],"affiliations":[{"raw_affiliation_string":"Inserm, U973, Paris 75013, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013189942","display_name":"Laura M. L. Bourbon","orcid":null},"institutions":[{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura M. L. Bourbon","raw_affiliation_strings":["Inserm, U973, Paris 75013, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France"],"affiliations":[{"raw_affiliation_string":"Inserm, U973, Paris 75013, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063303881","display_name":"C\u00e9line M. Labb\u00e9","orcid":null},"institutions":[{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line M. Labb\u00e9","raw_affiliation_strings":["Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","Inserm, U973, Paris 75013, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","institution_ids":[]},{"raw_affiliation_string":"Inserm, U973, Paris 75013, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051589659","display_name":"Bruno O. Villoutreix","orcid":"https://orcid.org/0000-0002-6456-7730"},"institutions":[{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno O. Villoutreix","raw_affiliation_strings":["Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","Inserm, U973, Paris 75013, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","institution_ids":[]},{"raw_affiliation_string":"Inserm, U973, Paris 75013, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064154680","display_name":"Olivier Sp\u00e9randio","orcid":"https://orcid.org/0000-0001-6610-2729"},"institutions":[{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Sperandio","raw_affiliation_strings":["Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","Inserm, U973, Paris 75013, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9\rde Pharmacie, CDithem, 1 rue du Prof Laguesse, 59000 Lille, France","institution_ids":[]},{"raw_affiliation_string":"Inserm, U973, Paris 75013, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMRS 973 Inserm, Paris 75013, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078099175"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I169173203","https://openalex.org/I204730241","https://openalex.org/I4210091437"],"apc_list":null,"apc_paid":null,"fwci":6.9459,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.97280328,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"54","issue":"11","first_page":"3067","last_page":"3079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5762268900871277},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5234760046005249},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43812164664268494},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3908463418483734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3071172833442688},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19546642899513245}],"concepts":[{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5762268900871277},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5234760046005249},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43812164664268494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3908463418483734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3071172833442688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19546642899513245}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci500487q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500487q","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:25285479","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25285479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2290407640","display_name":null,"funder_award_id":"ANR-09-PIRI-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1968682237","https://openalex.org/W1979414133","https://openalex.org/W1979814868","https://openalex.org/W1980621088","https://openalex.org/W1992229282","https://openalex.org/W1994999769","https://openalex.org/W2006240112","https://openalex.org/W2022321356","https://openalex.org/W2032389990","https://openalex.org/W2038359277","https://openalex.org/W2038555943","https://openalex.org/W2044876995","https://openalex.org/W2049894936","https://openalex.org/W2052002840","https://openalex.org/W2053548662","https://openalex.org/W2062458432","https://openalex.org/W2070506154","https://openalex.org/W2072890254","https://openalex.org/W2074370114","https://openalex.org/W2083354933","https://openalex.org/W2084706776","https://openalex.org/W2087768671","https://openalex.org/W2087836387","https://openalex.org/W2092285329","https://openalex.org/W2095375069","https://openalex.org/W2096864392","https://openalex.org/W2100125011","https://openalex.org/W2110336366","https://openalex.org/W2110952157","https://openalex.org/W2121666644","https://openalex.org/W2128247932","https://openalex.org/W2135732933","https://openalex.org/W2138314961","https://openalex.org/W2141528038","https://openalex.org/W2142912491","https://openalex.org/W2155721378","https://openalex.org/W2162083477","https://openalex.org/W2162723974","https://openalex.org/W2168363281","https://openalex.org/W2169303530","https://openalex.org/W2951155765","https://openalex.org/W4213151958"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2099982459","https://openalex.org/W1982038138","https://openalex.org/W2109298101","https://openalex.org/W2159860826","https://openalex.org/W2133294187","https://openalex.org/W4390876228","https://openalex.org/W3192210502","https://openalex.org/W1998222399","https://openalex.org/W2007507741"],"abstract_inverted_index":{"The":[0,102],"specific":[1],"properties":[2,22,105,129],"of":[3,23,26,34,57,61,63,99,111,125,127,136],"protein-protein":[4],"interactions":[5],"(PPI)":[6],"(flat,":[7],"large":[8],"and":[9,59,133],"hydrophobic)":[10],"make":[11],"them":[12],"harder":[13],"to":[14,43,68,88,90,142],"tackle":[15],"with":[16,130,146],"low-molecular-weight":[17],"compounds.":[18],"Learning":[19],"from":[20],"the":[21,54,76,91,97,123,131,134,137],"successful":[24],"examples":[25],"PPI":[27],"interface":[28],"inhibitors":[29,62],"(iPPI)":[30],"at":[31,96],"earlier":[32],"stages":[33],"developments,":[35],"has":[36],"been":[37],"pinpointed":[38],"as":[39,109],"a":[40],"powerful":[41],"strategy":[42],"circumvent":[44],"this":[45,48,81],"trend.":[46],"To":[47],"end,":[49],"we":[50],"have":[51],"computationally":[52],"analyzed":[53],"bioactive":[55],"conformations":[56],"iPPI":[58,71,86,112,145],"those":[60],"conventional":[64],"targets":[65],"(e.g":[66,118],"enzymes)":[67],"highlight":[69],"putative":[70],"3D":[72],"characteristics.":[73],"Most":[74],"noticeably,":[75],"essential":[77],"property":[78],"revealed":[79],"by":[80],"study":[82],"illustrates":[83],"how":[84],"efficiently":[85],"manages":[87],"bind":[89],"hydrophobic":[92],"patch":[93],"often":[94],"present":[95],"core":[98],"protein":[100],"interfaces.":[101],"newly":[103],"identified":[104],"were":[106],"further":[107],"confirmed":[108],"characteristics":[110],"using":[113],"much":[114],"larger":[115],"data":[116],"sets":[117],"iPPI-DB,":[119],"www.ippidb.cdithem.fr":[120],").":[121],"Interestingly,":[122],"absence":[124],"correlation":[126],"such":[128],"hydrophobicity":[132],"size":[135],"compounds":[138],"opens":[139],"new":[140],"ways":[141],"design":[143],"potent":[144],"better":[147],"pharmacokinetic":[148],"features.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8}],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2025-10-10T00:00:00"}
