{"id":"https://openalex.org/W2063297077","doi":"https://doi.org/10.1021/ci500448e","title":"Truncated Variants of the GCN4 Transcription Activator Protein Bind DNA with Dramatically Different Dynamical Motifs","display_name":"Truncated Variants of the GCN4 Transcription Activator Protein Bind DNA with Dramatically Different Dynamical Motifs","publication_year":2014,"publication_date":"2014-09-22","ids":{"openalex":"https://openalex.org/W2063297077","doi":"https://doi.org/10.1021/ci500448e","mag":"2063297077","pmid":"https://pubmed.ncbi.nlm.nih.gov/25204850"},"language":"en","primary_location":{"id":"doi:10.1021/ci500448e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500448e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055289658","display_name":"Danielle M. McHarris","orcid":null},"institutions":[{"id":"https://openalex.org/I104579289","display_name":"Utica College","ror":"https://ror.org/002ygss10","country_code":"US","type":"education","lineage":["https://openalex.org/I104579289"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Danielle M. McHarris","raw_affiliation_strings":["Department\rof Chemistry and\rBiochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States","Department of Chemistry and Biochemistry, Utica College , 1600 Burrstone Road, Utica, New York 13502, United States"],"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry and\rBiochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States","institution_ids":["https://openalex.org/I104579289"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Utica College , 1600 Burrstone Road, Utica, New York 13502, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025797891","display_name":"Daniel Barr","orcid":"https://orcid.org/0000-0003-4660-5649"},"institutions":[{"id":"https://openalex.org/I104579289","display_name":"Utica College","ror":"https://ror.org/002ygss10","country_code":"US","type":"education","lineage":["https://openalex.org/I104579289"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Barr","raw_affiliation_strings":["Department\rof Chemistry and\rBiochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States","Department#R#of Chemistry and#R#Biochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States"],"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry and\rBiochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States","institution_ids":["https://openalex.org/I104579289"]},{"raw_affiliation_string":"Department#R#of Chemistry and#R#Biochemistry, Utica College, 1600 Burrstone Road, Utica, New York 13502, United States","institution_ids":["https://openalex.org/I104579289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055289658"],"corresponding_institution_ids":["https://openalex.org/I104579289"],"apc_list":null,"apc_paid":null,"fwci":0.1394,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53474017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"54","issue":"10","first_page":"2869","last_page":"2875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucine-zipper","display_name":"Leucine zipper","score":0.8541356921195984},{"id":"https://openalex.org/keywords/bzip-domain","display_name":"bZIP domain","score":0.7506159543991089},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5842158198356628},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5031084418296814},{"id":"https://openalex.org/keywords/activator","display_name":"Activator (genetics)","score":0.5008583068847656},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.47050708532333374},{"id":"https://openalex.org/keywords/hmg-box","display_name":"HMG-box","score":0.45237457752227783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44881361722946167},{"id":"https://openalex.org/keywords/dna-binding-protein","display_name":"DNA-binding protein","score":0.44387465715408325},{"id":"https://openalex.org/keywords/zipper","display_name":"Zipper","score":0.4312197268009186},{"id":"https://openalex.org/keywords/basic-helix-loop-helix-leucine-zipper-transcription-factors","display_name":"Basic helix-loop-helix leucine zipper transcription factors","score":0.4244967997074127},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35785675048828125},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3294113278388977},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3277105689048767},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3161465525627136}],"concepts":[{"id":"https://openalex.org/C156860981","wikidata":"https://www.wikidata.org/wiki/Q2565229","display_name":"Leucine zipper","level":4,"score":0.8541356921195984},{"id":"https://openalex.org/C19408993","wikidata":"https://www.wikidata.org/wiki/Q24784063","display_name":"bZIP domain","level":5,"score":0.7506159543991089},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5842158198356628},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5031084418296814},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5008583068847656},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47050708532333374},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.45237457752227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44881361722946167},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.44387465715408325},{"id":"https://openalex.org/C105782903","wikidata":"https://www.wikidata.org/wiki/Q6577686","display_name":"Zipper","level":2,"score":0.4312197268009186},{"id":"https://openalex.org/C202908374","wikidata":"https://www.wikidata.org/wiki/Q4867030","display_name":"Basic helix-loop-helix leucine zipper transcription factors","level":5,"score":0.4244967997074127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35785675048828125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3294113278388977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3277105689048767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3161465525627136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci500448e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci500448e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:25204850","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25204850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W191042154","https://openalex.org/W1922068407","https://openalex.org/W1965127482","https://openalex.org/W1965139092","https://openalex.org/W1972758026","https://openalex.org/W1976499671","https://openalex.org/W1979925723","https://openalex.org/W1980722147","https://openalex.org/W1992743916","https://openalex.org/W1997657600","https://openalex.org/W2010941714","https://openalex.org/W2012318656","https://openalex.org/W2013018585","https://openalex.org/W2013334155","https://openalex.org/W2022935405","https://openalex.org/W2023592911","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2032975481","https://openalex.org/W2035687084","https://openalex.org/W2038758364","https://openalex.org/W2039478144","https://openalex.org/W2047033234","https://openalex.org/W2049151282","https://openalex.org/W2050333027","https://openalex.org/W2052390575","https://openalex.org/W2052650104","https://openalex.org/W2063006759","https://openalex.org/W2069662497","https://openalex.org/W2070676606","https://openalex.org/W2074718022","https://openalex.org/W2077887022","https://openalex.org/W2095994064","https://openalex.org/W2097585916","https://openalex.org/W2102503844","https://openalex.org/W2106140689","https://openalex.org/W2116058896","https://openalex.org/W2117152823","https://openalex.org/W2120973353","https://openalex.org/W2123182960","https://openalex.org/W2133122037","https://openalex.org/W2135643173","https://openalex.org/W2139026081","https://openalex.org/W2141920771","https://openalex.org/W2147339635","https://openalex.org/W2147461111","https://openalex.org/W2150945052","https://openalex.org/W2150981663","https://openalex.org/W2154456026","https://openalex.org/W2160451368","https://openalex.org/W2165032708","https://openalex.org/W2170711116","https://openalex.org/W2313141362","https://openalex.org/W3017082821"],"related_works":["https://openalex.org/W2051181331","https://openalex.org/W2552863639","https://openalex.org/W2164464592","https://openalex.org/W2267454943","https://openalex.org/W2066101080","https://openalex.org/W2250874172","https://openalex.org/W1982416144","https://openalex.org/W2978648441","https://openalex.org/W1997432622","https://openalex.org/W2537792747"],"abstract_inverted_index":{"The":[0],"yeast":[1],"protein":[2,39,83,120],"GCN4":[3,82],"is":[4,18],"a":[5,50,58],"transcriptional":[6],"activator":[7],"in":[8,64,117],"the":[9,19,27,38,47,68,80,94,106,113,118,125],"basic":[10],"leucine":[11],"zipper":[12],"(bZip)":[13],"family,":[14],"whose":[15],"distinguishing":[16],"feature":[17],"\"chopstick-like\"":[20],"homodimer":[21],"of":[22,37,49,61,79],"alpha":[23],"helices":[24],"formed":[25],"at":[26],"DNA-binding":[28,43,111],"interface.":[29],"While":[30],"experiments":[31],"have":[32,73],"shown":[33],"that":[34,54,93,104],"truncated":[35,88,95,107],"versions":[36],"retain":[40,110],"biologically":[41],"relevant":[42],"affinity,":[44],"we":[45],"present":[46,116],"results":[48],"computational":[51],"study":[52],"revealing":[53],"these":[55],"variants":[56],"show":[57,97],"wide":[59],"variety":[60],"dynamical":[62],"modes":[63],"their":[65],"interaction":[66],"with":[67],"target":[69],"DNA":[70],"sequence.":[71],"We":[72,102],"performed":[74],"all-atom":[75],"molecular":[76],"dynamics":[77],"simulations":[78],"full-length":[81,119],"as":[84,86],"well":[85],"three":[87],"variants;":[89],"our":[90],"data":[91],"indicate":[92],"mutants":[96,108],"dramatically":[98],"different":[99],"correlation":[100],"patterns.":[101],"conclude":[103],"although":[105],"still":[109],"ability,":[112],"bZip":[114],"interface":[115],"provides":[121],"important":[122],"stability":[123],"for":[124],"protein-DNA":[126],"complex.":[127]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}