{"id":"https://openalex.org/W2059464558","doi":"https://doi.org/10.1021/ci4007134","title":"Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening","display_name":"Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening","publication_year":2014,"publication_date":"2014-02-10","ids":{"openalex":"https://openalex.org/W2059464558","doi":"https://doi.org/10.1021/ci4007134","mag":"2059464558","pmid":"https://pubmed.ncbi.nlm.nih.gov/24512059"},"language":"en","primary_location":{"id":"doi:10.1021/ci4007134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci4007134","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101839372","display_name":"Ashutosh Kumar","orcid":"https://orcid.org/0000-0002-1699-2951"},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ashutosh Kumar","raw_affiliation_strings":["Zhang\rInitiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Zhang Initiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"],"affiliations":[{"raw_affiliation_string":"Zhang\rInitiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Zhang Initiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101538508","display_name":"Akihiro Ito","orcid":"https://orcid.org/0000-0003-0908-8929"},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Ito","raw_affiliation_strings":["Chemical\rGenetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Chemical#R#Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"],"affiliations":[{"raw_affiliation_string":"Chemical\rGenetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Chemical#R#Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058472903","display_name":"Misao Takemoto","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misao Takemoto","raw_affiliation_strings":["Drug\rDiscovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Drug#R#Discovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"],"affiliations":[{"raw_affiliation_string":"Drug\rDiscovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]},{"raw_affiliation_string":"Drug#R#Discovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024749444","display_name":"Minoru Yoshida","orcid":"https://orcid.org/0000-0002-4376-5674"},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Yoshida","raw_affiliation_strings":["Chemical\rGenetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Drug\rDiscovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Chemical#R#Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"],"affiliations":[{"raw_affiliation_string":"Chemical\rGenetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Drug\rDiscovery Platform Cooperation Division, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210100240"]},{"raw_affiliation_string":"Chemical#R#Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044307373","display_name":"Kam Y. J. Zhang","orcid":"https://orcid.org/0000-0002-9282-8045"},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kam Y. J. Zhang","raw_affiliation_strings":["Zhang\rInitiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","Zhang#R#Initiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"],"affiliations":[{"raw_affiliation_string":"Zhang\rInitiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Zhang#R#Initiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101839372"],"corresponding_institution_ids":["https://openalex.org/I4210110652"],"apc_list":null,"apc_paid":null,"fwci":2.0915,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.87098751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"54","issue":"3","first_page":"870","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.7081949710845947},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6880202889442444},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.6380259990692139},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4575369358062744},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4168590009212494},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3176751136779785},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2312602400779724},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16463473439216614},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.14073151350021362},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.13619214296340942},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12278634309768677}],"concepts":[{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.7081949710845947},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6880202889442444},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.6380259990692139},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4575369358062744},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4168590009212494},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3176751136779785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2312602400779724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16463473439216614},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.14073151350021362},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.13619214296340942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12278634309768677}],"mesh":[{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci4007134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci4007134","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24512059","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24512059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1593932445","https://openalex.org/W1971339462","https://openalex.org/W1973480232","https://openalex.org/W1981573620","https://openalex.org/W1983606049","https://openalex.org/W1984073552","https://openalex.org/W1985588649","https://openalex.org/W1987129537","https://openalex.org/W1989856356","https://openalex.org/W1992576746","https://openalex.org/W1993180829","https://openalex.org/W2003403265","https://openalex.org/W2007066406","https://openalex.org/W2009423060","https://openalex.org/W2010576862","https://openalex.org/W2015327652","https://openalex.org/W2024249948","https://openalex.org/W2026265322","https://openalex.org/W2030437460","https://openalex.org/W2034250162","https://openalex.org/W2034419650","https://openalex.org/W2038981079","https://openalex.org/W2039807741","https://openalex.org/W2041189078","https://openalex.org/W2043927273","https://openalex.org/W2046628354","https://openalex.org/W2047682152","https://openalex.org/W2051381895","https://openalex.org/W2051961867","https://openalex.org/W2052388749","https://openalex.org/W2054096989","https://openalex.org/W2065014569","https://openalex.org/W2070223839","https://openalex.org/W2078374001","https://openalex.org/W2084501381","https://openalex.org/W2087630722","https://openalex.org/W2088459327","https://openalex.org/W2090431249","https://openalex.org/W2101844404","https://openalex.org/W2102377211","https://openalex.org/W2111826195","https://openalex.org/W2116211618","https://openalex.org/W2121619038","https://openalex.org/W2121853844","https://openalex.org/W2125074509","https://openalex.org/W2135732933","https://openalex.org/W2136956610","https://openalex.org/W2139945268","https://openalex.org/W2147421370","https://openalex.org/W2164467344","https://openalex.org/W2164764996","https://openalex.org/W2167376504","https://openalex.org/W2411609717"],"related_works":["https://openalex.org/W3180887190","https://openalex.org/W2320211095","https://openalex.org/W2308164565","https://openalex.org/W2062768126","https://openalex.org/W3003855012","https://openalex.org/W2059230675","https://openalex.org/W2347569454","https://openalex.org/W4241018400","https://openalex.org/W4211208557","https://openalex.org/W1566373881"],"abstract_inverted_index":{"Small":[0],"ubiquitin":[1],"like":[2],"modifier":[3],"(SUMO)":[4],"specific":[5],"proteases":[6,10],"(SENPs)":[7],"are":[8,34],"cysteine":[9],"that":[11,107,139,184,272],"carry":[12],"out":[13],"the":[14,26,46,52,102,115,158,194,199,247,282],"proteolytic":[15],"processing":[16],"of":[17,28,48,79,86,104,117,148,160,173,189,202,215,226,234,240,246,284],"SUMO":[18,29],"from":[19,30],"its":[20],"pro":[21],"form":[22],"as":[23,25,263,277],"well":[24],"deconjugation":[27],"substrate":[31,122],"proteins.":[32],"SENPs":[33,53],"attractive":[35],"targets":[36],"for":[37,134,281],"drug":[38],"discovery":[39,55],"due":[40],"to":[41,129,177],"their":[42,141],"crucial":[43],"role":[44],"in":[45,212],"development":[47,283],"various":[49,289],"diseases.":[50],"However,":[51],"inhibitor":[54],"efforts":[56],"were":[57,210],"limited,":[58],"and":[59,91,111,121,197,242,265],"only":[60],"a":[61,76,84,135,181,186,278],"few":[62],"inhibitors":[63,81],"or":[64],"activity":[65,225],"based":[66,88,94,137,154],"probes":[67],"have":[68,108],"been":[69],"identified":[70,82,211],"until":[71],"now.":[72],"Here,":[73],"we":[74],"report":[75],"new":[77],"class":[78,188],"SENP2":[80,142,165,190,223],"by":[83,152],"combination":[85],"structure":[87],"virtual":[89,97,149,216],"screening":[90,98,150],"quantitative":[92],"FRET":[93,136,153],"assay.":[95],"Our":[96,269],"protocol":[99],"initially":[100],"involves":[101],"identification":[103,159],"small":[105,132],"molecules":[106,133],"similar":[109],"shape":[110],"electrostatic":[112],"properties":[113],"with":[114,163],"conjugate":[116],"SUMO1":[118],"C-terminal":[119],"residues":[120],"lysine.":[123],"Molecular":[124],"docking":[125],"was":[126,267],"then":[127],"used":[128,276],"prioritize":[130],"these":[131,174,203,227],"assay":[138,155,220],"quantifies":[140],"endopeptidase":[143],"activity.":[144],"The":[145,218,230],"initial":[146],"round":[147,214],"followed":[151],"has":[156],"enabled":[157],"eight":[161],"compounds":[162,175,209,248],">40%":[164],"inhibition":[166,258],"at":[167],"30":[168],"\u03bcM":[169],"compound":[170,233],"concentration.":[171],"Five":[172],"belong":[176],"two":[178,204,228],"scaffolds":[179],"containing":[180],"1,2,5-oxadiazole":[182,205],"core":[183],"represent":[185],"novel":[187,285],"inhibitors.":[191],"To":[192],"improve":[193],"inhibitory":[195,224],"potency":[196],"explore":[198],"structure-activity":[200],"relationship":[201],"scaffolds,":[206],"structurally":[207],"related":[208,252],"another":[213],"screening.":[217],"biological":[219],"results":[221],"confirmed":[222],"scaffolds.":[229],"most":[231],"potent":[232],"each":[235],"scaffold":[236],"showed":[237],"an":[238],"IC50":[239],"5.9":[241],"3.7":[243],"\u03bcM.":[244],"Most":[245],"also":[249],"inhibited":[250],"closely":[251],"isoform":[253],"SENP1,":[254],"while":[255],"no":[256],"detectable":[257],"on":[259],"other":[260],"proteases,":[261],"such":[262],"papain":[264],"trypsin,":[266],"observed.":[268],"study":[270],"suggests":[271],"1,2,5-oxadiazoles":[273],"could":[274],"be":[275],"starting":[279],"point":[280],"therapeutic":[286],"agents":[287],"against":[288],"diseases":[290],"targeting":[291],"SENPs.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}