{"id":"https://openalex.org/W2085925763","doi":"https://doi.org/10.1021/ci400493a","title":"Comparative Study on the Use of Docking and Bayesian Categorization To Predict Ligand Binding to Nicotinic Acetylcholine Receptors (nAChRs) Subtypes","display_name":"Comparative Study on the Use of Docking and Bayesian Categorization To Predict Ligand Binding to Nicotinic Acetylcholine Receptors (nAChRs) Subtypes","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W2085925763","doi":"https://doi.org/10.1021/ci400493a","mag":"2085925763","pmid":"https://pubmed.ncbi.nlm.nih.gov/24328365"},"language":"en","primary_location":{"id":"doi:10.1021/ci400493a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400493a","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025312518","display_name":"David C. Kombo","orcid":"https://orcid.org/0009-0002-7746-0358"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David C. Kombo","raw_affiliation_strings":["Targacept, Inc., 100 North Main Street, Winston-Salem, North Carolina 27101, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Targacept, Inc., 100 North Main Street, Winston-Salem, North Carolina 27101, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004880516","display_name":"Merouane Bencherif","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merouane Bencherif","raw_affiliation_strings":["Targacept, Inc., 100 North Main Street, Winston-Salem, North Carolina 27101, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Targacept, Inc., 100 North Main Street, Winston-Salem, North Carolina 27101, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025312518"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8977,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74454436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"53","issue":"12","first_page":"3212","last_page":"3222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.786697268486023},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6220638751983643},{"id":"https://openalex.org/keywords/nicotinic-agonist","display_name":"Nicotinic agonist","score":0.5847746729850769},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.5536841750144958},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5100861191749573},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.49235355854034424},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.4760960340499878},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42970699071884155},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.32023540139198303},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2570849359035492},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19401279091835022},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.12066870927810669}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.786697268486023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6220638751983643},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.5847746729850769},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.5536841750144958},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5100861191749573},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.49235355854034424},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4760960340499878},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42970699071884155},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32023540139198303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2570849359035492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19401279091835022},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12066870927810669},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400493a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400493a","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24328365","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24328365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W73217504","https://openalex.org/W1483942114","https://openalex.org/W1928390080","https://openalex.org/W1963597328","https://openalex.org/W1974952480","https://openalex.org/W1978391071","https://openalex.org/W1980137138","https://openalex.org/W1981708439","https://openalex.org/W1989833754","https://openalex.org/W1992556352","https://openalex.org/W1992948117","https://openalex.org/W2005386196","https://openalex.org/W2006420867","https://openalex.org/W2007353473","https://openalex.org/W2009858788","https://openalex.org/W2017055158","https://openalex.org/W2022538207","https://openalex.org/W2030251552","https://openalex.org/W2033083825","https://openalex.org/W2035857944","https://openalex.org/W2042216385","https://openalex.org/W2047860814","https://openalex.org/W2064743177","https://openalex.org/W2065283382","https://openalex.org/W2072012688","https://openalex.org/W2072444571","https://openalex.org/W2073295417","https://openalex.org/W2078656887","https://openalex.org/W2081719547","https://openalex.org/W2085657703","https://openalex.org/W2087482033","https://openalex.org/W2093046520","https://openalex.org/W2102377211","https://openalex.org/W2105597022","https://openalex.org/W2106431483","https://openalex.org/W2125792789","https://openalex.org/W2135860083","https://openalex.org/W2145877612","https://openalex.org/W2155741020","https://openalex.org/W2158095037","https://openalex.org/W2163994482","https://openalex.org/W2166403013","https://openalex.org/W2166955092","https://openalex.org/W2171954198","https://openalex.org/W2463054001"],"related_works":["https://openalex.org/W2130031978","https://openalex.org/W2090149287","https://openalex.org/W3043724143","https://openalex.org/W2336465572","https://openalex.org/W2399953650","https://openalex.org/W3197423116","https://openalex.org/W1966343877","https://openalex.org/W2423377342","https://openalex.org/W1974734322","https://openalex.org/W2347916519"],"abstract_inverted_index":{"We":[0,37,142],"have":[1],"carried":[2],"out":[3],"a":[4,68,110],"comparative":[5],"study":[6],"between":[7,72],"docking":[8,55,60,122],"into":[9,56],"homology":[10,57],"models":[11],"and":[12,30,35,51,79,150,174],"Bayesian":[13,46,124],"categorization,":[14],"as":[15,137],"applied":[16],"to":[17,116,157,202],"virtual":[18],"screening":[19],"of":[20,76,84,112,171,180],"nicotinic":[21,113,199],"ligands":[22,114,173,200],"for":[23,139],"binding":[24,115,182,201],"at":[25],"various":[26],"nAChRs":[27],"subtypes":[28],"(human":[29],"rat":[31],"\u03b14\u03b22,":[32],"\u03b17,":[33],"\u03b13\u03b24,":[34],"\u03b16\u03b22\u03b23).":[36],"found":[38,144],"that":[39,106,145,193],"although":[40],"results":[41],"vary":[42],"with":[43,97,127,163,190],"receptor":[44],"subtype,":[45],"categorization":[47],"exhibits":[48],"higher":[49],"accuracy":[50,61],"enrichment":[52,148,153],"than":[53],"unconstrained":[54],"models.":[58],"However,":[59],"is":[62,109,187],"improved":[63],"when":[64,132],"one":[65],"sets":[66],"up":[67],"hydrogen-bond":[69],"(HB)":[70],"constraint":[71],"the":[73,77,80,85,98,128,164,175,181,191],"cationic":[74],"center":[75],"ligand":[78,99],"main-chain":[81],"carbonyl":[82],"group":[83],"conserved":[86],"Trp-149":[87],"or":[88,123],"its":[89],"homologue":[90],"(a":[91],"residue":[92],"involved":[93],"in":[94,188,197],"cation-\u03c0":[95],"interactions":[96],"basic":[100],"nitrogen":[101],"atom).":[102],"This":[103,185],"finding":[104],"suggests":[105],"this":[107],"HB":[108],"hallmark":[111],"nAChRs.":[117,205],"Best":[118],"predictions":[119],"using":[120],"either":[121],"were":[125],"obtained":[126],"human":[129],"\u03b17":[130],"nAChR,":[131],"100":[133],"nM":[134],"was":[135],"used":[136],"cutoff":[138],"biological":[140],"activity.":[141],"also":[143],"ligand-based":[146],"Bayesian-derived":[147],"factors":[149,154],"structure-based":[151],"docking-derived":[152],"highly":[155],"correlate":[156,162],"each":[158],"other.":[159],"Moreover,":[160],"they":[161],"mean":[165],"molecular":[166],"fractional":[167,176],"polar":[168],"surface":[169,178],"area":[170,179],"actives":[172],"hydrophobic/hydrophilic":[177],"site,":[183],"respectively.":[184],"result":[186],"agreement":[189],"fact":[192],"hydrophobicity":[194],"strongly":[195],"contributes":[196],"promoting":[198],"their":[203],"cognate":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}