{"id":"https://openalex.org/W2077249477","doi":"https://doi.org/10.1021/ci400480s","title":"Fusing Dual-Event Data Sets for <i>Mycobacterium tuberculosis</i> Machine Learning Models and Their Evaluation","display_name":"Fusing Dual-Event Data Sets for <i>Mycobacterium tuberculosis</i> Machine Learning Models and Their Evaluation","publication_year":2013,"publication_date":"2013-10-21","ids":{"openalex":"https://openalex.org/W2077249477","doi":"https://doi.org/10.1021/ci400480s","mag":"2077249477","pmid":"https://pubmed.ncbi.nlm.nih.gov/24144044"},"language":"en","primary_location":{"id":"doi:10.1021/ci400480s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400480s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073973321","display_name":"Sean Ekins","orcid":"https://orcid.org/0000-0002-5691-5790"},"institutions":[{"id":"https://openalex.org/I4210147836","display_name":"Collaborative Drug Discovery (United States)","ror":"https://ror.org/04b4sq284","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147836"]},{"id":"https://openalex.org/I4210148032","display_name":"Collaborations Pharmaceuticals (United States)","ror":"https://ror.org/04m718665","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean Ekins","raw_affiliation_strings":["Collaborations\rin Chemistry, 5616 Hilltop\rNeedmore Road, Fuquay-Varina, North Carolina 27526, United States","Collaborative\rDrug Discovery, 1633 Bayshore\rHighway, Suite 342, Burlingame, California 94010, United States","Collaborative Drug Discovery , 1633 Bayshore Highway, Suite 342, Burlingame, California 94010, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborations\rin Chemistry, 5616 Hilltop\rNeedmore Road, Fuquay-Varina, North Carolina 27526, United States","institution_ids":["https://openalex.org/I4210148032"]},{"raw_affiliation_string":"Collaborative\rDrug Discovery, 1633 Bayshore\rHighway, Suite 342, Burlingame, California 94010, United States","institution_ids":["https://openalex.org/I4210147836"]},{"raw_affiliation_string":"Collaborative Drug Discovery , 1633 Bayshore Highway, Suite 342, Burlingame, California 94010, United States","institution_ids":["https://openalex.org/I4210147836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044700909","display_name":"Joel S. Freundlich","orcid":"https://orcid.org/0000-0002-3411-3455"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Freundlich","raw_affiliation_strings":["Department\rof Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University \u2212 New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States","Department of Pharmacology & Physiology, Rutgers University \u2212 New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University \u2212 New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Department of Pharmacology & Physiology, Rutgers University \u2212 New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066715892","display_name":"Robert C. Reynolds","orcid":"https://orcid.org/0000-0001-9413-2247"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Reynolds","raw_affiliation_strings":["Department\rof Chemistry, University of Alabama at Birmingham, College of Arts and Sciences, 1530 Third Avenue South, Birmingham, Alabama 35294-1240, United States","Department#R#of Chemistry, University of Alabama at Birmingham, College of Arts and Sciences, 1530 Third Avenue South, Birmingham, Alabama 35294-1240, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Alabama at Birmingham, College of Arts and Sciences, 1530 Third Avenue South, Birmingham, Alabama 35294-1240, United States","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department#R#of Chemistry, University of Alabama at Birmingham, College of Arts and Sciences, 1530 Third Avenue South, Birmingham, Alabama 35294-1240, United States","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073973321"],"corresponding_institution_ids":["https://openalex.org/I4210147836","https://openalex.org/I4210148032"],"apc_list":null,"apc_paid":null,"fwci":3.9195,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93830731,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"53","issue":"11","first_page":"3054","last_page":"3063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.7398957014083862},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6676000356674194},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6440346837043762},{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.6071045994758606},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.5990344285964966},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.5981338620185852},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.5743507146835327},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5321295261383057},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.49101710319519043},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.47046908736228943},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4304811954498291},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.3604690432548523},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20654436945915222},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1542169451713562},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10090360045433044}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.7398957014083862},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6676000356674194},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6440346837043762},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.6071045994758606},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.5990344285964966},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.5981338620185852},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5743507146835327},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5321295261383057},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.49101710319519043},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.47046908736228943},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4304811954498291},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.3604690432548523},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20654436945915222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1542169451713562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10090360045433044},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci400480s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400480s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24144044","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24144044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:europepmc.org:3207962","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3910492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9200000166893005}],"awards":[{"id":"https://openalex.org/G1647148719","display_name":null,"funder_award_id":"R42 AI088893","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1919303061","display_name":null,"funder_award_id":"R44 TR000942","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2632969611","display_name":null,"funder_award_id":"RC1 AI086677","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3254061458","display_name":null,"funder_award_id":"R41 AI088893","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5570953952","display_name":null,"funder_award_id":"1RC1AI086677-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7444421159","display_name":null,"funder_award_id":"2R42AI088893-02","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8269186347","display_name":null,"funder_award_id":"R43 LM011152","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G874937439","display_name":null,"funder_award_id":"R43LM011152-01","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W58105655","https://openalex.org/W1546015235","https://openalex.org/W1828735316","https://openalex.org/W1964141703","https://openalex.org/W1964484331","https://openalex.org/W1967396133","https://openalex.org/W1968135993","https://openalex.org/W1974166884","https://openalex.org/W1974242110","https://openalex.org/W1980801609","https://openalex.org/W1982647101","https://openalex.org/W1983394040","https://openalex.org/W1986106712","https://openalex.org/W1986288809","https://openalex.org/W1988600626","https://openalex.org/W2003408533","https://openalex.org/W2003537793","https://openalex.org/W2007560618","https://openalex.org/W2016709947","https://openalex.org/W2020973204","https://openalex.org/W2020983758","https://openalex.org/W2031216614","https://openalex.org/W2031441006","https://openalex.org/W2034080889","https://openalex.org/W2035417048","https://openalex.org/W2035776068","https://openalex.org/W2040135138","https://openalex.org/W2041253429","https://openalex.org/W2046613566","https://openalex.org/W2046842230","https://openalex.org/W2048080607","https://openalex.org/W2048779347","https://openalex.org/W2049773909","https://openalex.org/W2050145466","https://openalex.org/W2054203041","https://openalex.org/W2056881083","https://openalex.org/W2059282893","https://openalex.org/W2066532920","https://openalex.org/W2073871444","https://openalex.org/W2076461322","https://openalex.org/W2076714386","https://openalex.org/W2077727142","https://openalex.org/W2081770014","https://openalex.org/W2085507946","https://openalex.org/W2085684476","https://openalex.org/W2091515885","https://openalex.org/W2092269828","https://openalex.org/W2092616995","https://openalex.org/W2096132672","https://openalex.org/W2101613321","https://openalex.org/W2101646342","https://openalex.org/W2102794349","https://openalex.org/W2102952492","https://openalex.org/W2107184926","https://openalex.org/W2110820547","https://openalex.org/W2113504145","https://openalex.org/W2113972754","https://openalex.org/W2115544494","https://openalex.org/W2116652199","https://openalex.org/W2116976305","https://openalex.org/W2124462881","https://openalex.org/W2125852843","https://openalex.org/W2129075135","https://openalex.org/W2140716928","https://openalex.org/W2142602210","https://openalex.org/W2142733912","https://openalex.org/W2148244985","https://openalex.org/W2149675395","https://openalex.org/W2151803551","https://openalex.org/W2152841520","https://openalex.org/W2155741020","https://openalex.org/W2158023121","https://openalex.org/W2158658436","https://openalex.org/W2161459134","https://openalex.org/W2162246740","https://openalex.org/W2163576609","https://openalex.org/W2167773607","https://openalex.org/W2171660521","https://openalex.org/W2334300319","https://openalex.org/W2402340532","https://openalex.org/W3120421331","https://openalex.org/W4210370830"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4387327236","https://openalex.org/W2183488467","https://openalex.org/W1990237101","https://openalex.org/W4309907966","https://openalex.org/W4387896287","https://openalex.org/W2187490799","https://openalex.org/W3170838353"],"abstract_inverted_index":{"The":[0],"search":[1],"for":[2,191,223,243],"new":[3],"tuberculosis":[4,39],"treatments":[5],"continues":[6],"as":[7,227],"we":[8],"need":[9],"to":[10,95,120,125,210,249],"find":[11],"molecules":[12,110],"that":[13,135,167,201],"can":[14,177],"act":[15],"more":[16],"quickly,":[17],"be":[18,208,240],"accommodated":[19],"in":[20,145,153,181],"multidrug":[21],"regimens,":[22],"and":[23,59,100,142,234],"overcome":[24],"ever":[25],"increasing":[26],"levels":[27],"of":[28,49,106,117,130,160,196,213,232],"drug":[29],"resistance.":[30],"Multiple":[31],"large":[32,65],"scale":[33],"phenotypic":[34],"high-throughput":[35],"screens":[36,151],"against":[37],"Mycobacterium":[38],"(Mtb)":[40],"have":[41,170],"generated":[42,248],"dose":[43],"response":[44],"data,":[45],"enabling":[46],"the":[47,127,131,171,244],"generation":[48],"machine":[50,76,204,224],"learning":[51,205,225],"models.":[52,103,132],"These":[53],"models":[54,180],"also":[55,239],"incorporated":[56],"cytotoxicity":[57,119,143],"data":[58,67,98,138,144,247],"were":[60,123],"recently":[61,193],"validated":[62],"with":[63,111,189,229],"a":[64,182,192,219],"external":[66,154],"set.":[68],"A":[69,104],"cheminformatics":[70],"data-fusion":[71],"approach":[72],"followed":[73],"by":[74],"Bayesian":[75],"learning,":[77],"Support":[78],"Vector":[79],"Machine,":[80],"or":[81,163],"Recursive":[82],"Partitioning":[83],"model":[84,206],"development":[85],"(based":[86],"on":[87],"publicly":[88],"available":[89,109],"Mtb":[90,197,235],"screening":[91,246],"data)":[92],"was":[93],"used":[94,124],"compare":[96],"individual":[97],"sets":[99,139],"subsequent":[101],"combined":[102],"set":[105,184,195,216],"1924":[107],"commercially":[108],"promising":[112],"antitubercular":[113,141],"activity":[114],"(and":[115],"lack":[116],"relative":[118],"Vero":[121,146],"cells)":[122],"evaluate":[126],"predictive":[128],"nature":[129],"We":[133,187],"demonstrate":[134,188],"combining":[136],"three":[137],"incorporating":[140],"cells":[147],"from":[148,199],"our":[149],"previous":[150],"results":[152],"validation":[155],"receiver":[156],"operator":[157],"curve":[158],"(ROC)":[159],"0.83":[161],"(Bayesian":[162],"RP":[164],"Forest).":[165],"Models":[166],"do":[168],"not":[169],"highest":[172],"5-fold":[173],"cross-validation":[174],"ROC":[175],"scores":[176],"outperform":[178],"other":[179],"test":[183],"dependent":[185],"manner.":[186],"predictions":[190],"published":[194],"leads":[198],"GlaxoSmithKline":[200],"no":[202],"single":[203],"may":[207,238],"enough":[209],"identify":[211],"compounds":[212],"interest.":[214],"Data":[215],"fusion":[217],"represents":[218],"further":[220],"useful":[221],"strategy":[222],"construction":[226],"illustrated":[228],"Mtb.":[230],"Coverage":[231],"chemistry":[233],"target":[236],"spaces":[237],"limiting":[241],"factors":[242],"whole-cell":[245],"date.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2016-06-24T00:00:00"}