{"id":"https://openalex.org/W2085999395","doi":"https://doi.org/10.1021/ci400456m","title":"Computational Modeling of an Epidermal Growth Factor Receptor Single-Mutation Resistance to Cetuximab in Colorectal Cancer Treatment","display_name":"Computational Modeling of an Epidermal Growth Factor Receptor Single-Mutation Resistance to Cetuximab in Colorectal Cancer Treatment","publication_year":2013,"publication_date":"2013-11-12","ids":{"openalex":"https://openalex.org/W2085999395","doi":"https://doi.org/10.1021/ci400456m","mag":"2085999395","pmid":"https://pubmed.ncbi.nlm.nih.gov/24219403"},"language":"en","primary_location":{"id":"doi:10.1021/ci400456m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400456m","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036237864","display_name":"Ignasi Buch","orcid":null},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignasi Buch","raw_affiliation_strings":["Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","Computational Biophysics Laboratory (GRIB-IMIM) , Universitat Pompeu Fabra, Barcelona Biomedical Research Park (PRBB) , C/Doctor Aiguader 88 , 08003 Barcelona , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I170486558"]},{"raw_affiliation_string":"Computational Biophysics Laboratory (GRIB-IMIM) , Universitat Pompeu Fabra, Barcelona Biomedical Research Park (PRBB) , C/Doctor Aiguader 88 , 08003 Barcelona , Spain","institution_ids":["https://openalex.org/I2801864671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004684799","display_name":"Noelia Ferruz","orcid":"https://orcid.org/0000-0003-4172-8201"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noelia Ferruz","raw_affiliation_strings":["Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","Computational Biophysics#R#Laboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical#R#Research Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I170486558"]},{"raw_affiliation_string":"Computational Biophysics#R#Laboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical#R#Research Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027026045","display_name":"Gianni De Fabritiis","orcid":"https://orcid.org/0000-0003-3913-4877"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gianni De Fabritiis","raw_affiliation_strings":["Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","Computational Biophysics#R#Laboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical#R#Research Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biophysics\rLaboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical\rResearch Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I170486558"]},{"raw_affiliation_string":"Computational Biophysics#R#Laboratory (GRIB-IMIM), Universitat Pompeu Fabra, Barcelona Biomedical#R#Research Park (PRBB), C/Doctor Aiguader 88, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6334,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70576121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"53","issue":"12","first_page":"3123","last_page":"3126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"Cetuximab","score":0.9668821096420288},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.7412207722663879},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.7193412780761719},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5258917212486267},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5187309384346008},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4662555456161499},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.41016528010368347},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.406684547662735},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3950701355934143},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3346826732158661},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2767237722873688},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07433214783668518}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9668821096420288},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7412207722663879},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7193412780761719},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5258917212486267},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5187309384346008},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4662555456161499},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41016528010368347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.406684547662735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3950701355934143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3346826732158661},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2767237722873688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07433214783668518}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400456m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400456m","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24219403","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24219403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1970253348","https://openalex.org/W1975274124","https://openalex.org/W1983104536","https://openalex.org/W1991136643","https://openalex.org/W2002959795","https://openalex.org/W2006168411","https://openalex.org/W2010030578","https://openalex.org/W2034581192","https://openalex.org/W2035672721","https://openalex.org/W2036649302","https://openalex.org/W2041919461","https://openalex.org/W2048259134","https://openalex.org/W2049489032","https://openalex.org/W2050273205","https://openalex.org/W2058620780","https://openalex.org/W2059715478","https://openalex.org/W2068125497","https://openalex.org/W2069982778","https://openalex.org/W2072820038","https://openalex.org/W2080601747","https://openalex.org/W2082586732","https://openalex.org/W2105763574","https://openalex.org/W2156670712","https://openalex.org/W2169299331","https://openalex.org/W2317007959"],"related_works":["https://openalex.org/W1968282664","https://openalex.org/W2094962167","https://openalex.org/W4225893764","https://openalex.org/W2779013171","https://openalex.org/W2045259217","https://openalex.org/W3168072189","https://openalex.org/W2439403919","https://openalex.org/W4231029997","https://openalex.org/W2006466710","https://openalex.org/W4230462600"],"abstract_inverted_index":{"Extracellular":[0],"S468R":[1,49],"mutation":[2],"of":[3,16,36,61,65],"the":[4,14,32],"epidermal":[5],"growth":[6],"factor":[7],"receptor":[8],"(EGFR)":[9],"was":[10],"recently":[11],"identified":[12],"as":[13],"cause":[15],"resistance":[17,62],"to":[18,45],"cetuximab,":[19],"a":[20,58],"widely":[21],"used":[22],"drug":[23],"in":[24,63],"colorectal":[25],"cancer":[26],"treatment.":[27],"Here,":[28],"we":[29],"have":[30],"determined":[31],"binding":[33],"free":[34],"energies":[35],"cetuximab's":[37],"Fab":[38],"V(H)-V(L)":[39],"domains":[40],"and":[41,48],"endogenous":[42],"EGF":[43],"ligand":[44],"wild":[46],"type":[47],"EGFR":[50],"by":[51],"high-throughput":[52],"molecular":[53],"dynamics.":[54],"This":[55],"work":[56],"provides":[57],"possible":[59],"mechanism":[60],"terms":[64],"increased":[66],"competition,":[67],"an":[68],"hypothesis":[69],"that":[70],"can":[71],"be":[72],"further":[73],"validated":[74],"experimentally.":[75]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}