{"id":"https://openalex.org/W2112804624","doi":"https://doi.org/10.1021/ci400450h","title":"Binding Affinity Prediction for Protein\u2013Ligand Complexes Based on<i>\u03b2</i>Contacts and B Factor","display_name":"Binding Affinity Prediction for Protein\u2013Ligand Complexes Based on<i>\u03b2</i>Contacts and B Factor","publication_year":2013,"publication_date":"2013-11-05","ids":{"openalex":"https://openalex.org/W2112804624","doi":"https://doi.org/10.1021/ci400450h","mag":"2112804624","pmid":"https://pubmed.ncbi.nlm.nih.gov/24191692"},"language":"en","primary_location":{"id":"doi:10.1021/ci400450h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400450h","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037327117","display_name":"Qian Liu","orcid":"https://orcid.org/0000-0002-3162-935X"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Qian Liu","raw_affiliation_strings":["Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia","Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney , Sydney, New South Wales, NSW 2007 Australia"],"affiliations":[{"raw_affiliation_string":"Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney , Sydney, New South Wales, NSW 2007 Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027208445","display_name":"Chee Keong Kwoh","orcid":"https://orcid.org/0000-0002-8547-6387"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chee Keong Kwoh","raw_affiliation_strings":["Bioinformatics Research Center, School of Computer Engineering, Nanyang Technological University, 639798 Singapore","Bioinformatics#R#Research Center, School of Computer Engineering, Nanyang Technological University, 639798 Singapore"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, School of Computer Engineering, Nanyang Technological University, 639798 Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Bioinformatics#R#Research Center, School of Computer Engineering, Nanyang Technological University, 639798 Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017861049","display_name":"Jinyan Li","orcid":"https://orcid.org/0000-0003-1833-7413"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jinyan Li","raw_affiliation_strings":["Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia","Advanced#R#Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia"],"affiliations":[{"raw_affiliation_string":"Advanced Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia","institution_ids":["https://openalex.org/I114017466"]},{"raw_affiliation_string":"Advanced#R#Analytics Institute and Center for Health Technologies, University of Technology, Sydney, Sydney, New South Wales, NSW 2007 Australia","institution_ids":["https://openalex.org/I114017466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037327117"],"corresponding_institution_ids":["https://openalex.org/I114017466"],"apc_list":null,"apc_paid":null,"fwci":6.1632,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9682482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"53","issue":"11","first_page":"3076","last_page":"3085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.673972487449646},{"id":"https://openalex.org/keywords/protein-ligand","display_name":"Protein ligand","score":0.5333226919174194},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5214456915855408},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5107882022857666},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.45007896423339844},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41506487131118774},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.34215283393859863},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11118945479393005},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09528139233589172},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08815896511077881}],"concepts":[{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.673972487449646},{"id":"https://openalex.org/C109095088","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Protein ligand","level":2,"score":0.5333226919174194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5214456915855408},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5107882022857666},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.45007896423339844},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41506487131118774},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.34215283393859863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11118945479393005},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09528139233589172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08815896511077881},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400450h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400450h","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24191692","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24191692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1505394602","https://openalex.org/W1592950931","https://openalex.org/W1604071614","https://openalex.org/W1605578858","https://openalex.org/W1656114533","https://openalex.org/W1968682237","https://openalex.org/W1973191530","https://openalex.org/W1975567268","https://openalex.org/W1980337077","https://openalex.org/W1984021058","https://openalex.org/W1988111902","https://openalex.org/W1992441011","https://openalex.org/W1993403967","https://openalex.org/W2003356525","https://openalex.org/W2012084558","https://openalex.org/W2026453567","https://openalex.org/W2034763638","https://openalex.org/W2040617462","https://openalex.org/W2042071104","https://openalex.org/W2048207135","https://openalex.org/W2050456292","https://openalex.org/W2051163038","https://openalex.org/W2058146658","https://openalex.org/W2061079400","https://openalex.org/W2076022099","https://openalex.org/W2094966898","https://openalex.org/W2098971704","https://openalex.org/W2102377211","https://openalex.org/W2105527266","https://openalex.org/W2118587156","https://openalex.org/W2126638395","https://openalex.org/W2128332459","https://openalex.org/W2134967712","https://openalex.org/W2143251450","https://openalex.org/W2148512505","https://openalex.org/W2153504150","https://openalex.org/W2158360182","https://openalex.org/W2158534713","https://openalex.org/W2169562071","https://openalex.org/W2911964244"],"related_works":["https://openalex.org/W4389235921","https://openalex.org/W1485106526","https://openalex.org/W2031553931","https://openalex.org/W2331956508","https://openalex.org/W2885308902","https://openalex.org/W1997409847","https://openalex.org/W2005817231","https://openalex.org/W2078959398","https://openalex.org/W3008230527","https://openalex.org/W3131522312"],"abstract_inverted_index":{"Accurate":[0],"determination":[1],"of":[2,24,33,86,121,175,189,192,208,219,235,264],"protein-ligand":[3,20,34,78,132,209,275],"binding":[4,35,79,133,210],"affinity":[5,80],"is":[6,40,48,83,118],"a":[7,42,61,165,186],"fundamental":[8],"problem":[9,44],"in":[10,51,129,216],"biochemistry":[11],"useful":[12],"for":[13,30,77],"many":[14],"applications":[15],"including":[16],"drug":[17],"design":[18],"and":[19,104,185,204],"docking.":[21,276],"A":[22,89],"number":[23],"scoring":[25,63],"functions":[26],"have":[27,111],"been":[28],"proposed":[29],"the":[31,52,55,69,84,101,107,119,126,130,137,157,176,193,212],"prediction":[32,39,70,144],"affinity.":[36],"However,":[37],"accurate":[38],"still":[41],"challenging":[43],"because":[45],"poor":[46],"performance":[47,145],"often":[49],"seen":[50],"evaluation":[53,159],"under":[54,156],"leave-one-cluster-out":[56],"cross-validation":[57],"(LCOCV).":[58],"We":[59,199],"introduce":[60],"new":[62],"function":[64],"named":[65],"B2BScore":[66,72,141,163],"to":[67,99,124,146,183,197,225,252,273],"improve":[68],"performance.":[71],"integrates":[73],"two":[74,93,108],"physicochemical":[75],"properties":[76],"prediction.":[81],"One":[82],"property":[85,120],"\u03b2":[87,90],"contacts.":[88],"contact":[91,103,114,206],"between":[92,227],"atoms":[94,98,109,229,240,257],"requires":[95],"no":[96],"other":[97,117],"interrupt":[100],"atomic":[102,127],"assumes":[105],"that":[106],"should":[110],"enough":[112],"direct":[113],"area.":[115],"The":[116],"B":[122],"factor":[123],"capture":[125],"mobility":[128],"dynamic":[131],"process.":[134],"Tested":[135],"on":[136,149],"PDBBind2009":[138],"data":[139,152],"set,":[140],"shows":[142],"superior":[143],"existing":[147],"methods":[148],"independent":[150],"test":[151],"as":[153,155],"well":[154],"LCOCV":[158,167],"framework.":[160],"In":[161],"particular,":[162],"achieves":[164],"significant":[166,187],"improvement":[168],"across":[169],"26":[170],"protein":[171],"clusters-a":[172],"big":[173],"increase":[174],"averaged":[177],"Pearson's":[178],"correlation":[179],"coefficients":[180,194],"from":[181,195,241],"0.418":[182],"0.518":[184],"decrease":[188],"standard":[190],"deviation":[191],"0.352":[196],"0.196.":[198],"also":[200],"identified":[201],"several":[202],"important":[203],"intuitive":[205],"descriptors":[207,221,250,268],"through":[211],"random":[213],"forest":[214],"learning":[215],"B2BScore.":[217],"Some":[218,246],"these":[220],"are":[222,248],"closely":[223],"related":[224],"contacts":[226,234,254,263],"carbon":[228],"without":[230,258],"covalent-bond":[231,259],"oxygen/nitrogen,":[232],"preferred":[233],"metal":[236,265],"ions,":[237],"interfacial":[238],"backbone":[239],"proteins,":[242],"or":[243,261],"\u03c0":[244],"rings.":[245],"others":[247],"negative":[249],"relating":[251],"those":[253],"with":[255],"nitrogen":[256],"hydrogens":[260],"nonpreferred":[262],"ions.":[266],"These":[267],"can":[269],"be":[270],"directly":[271],"used":[272],"guide":[274]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}