{"id":"https://openalex.org/W2085168902","doi":"https://doi.org/10.1021/ci400421e","title":"Structurally Conserved Binding Sites of Hemagglutinin as Targets for Influenza Drug and Vaccine Development","display_name":"Structurally Conserved Binding Sites of Hemagglutinin as Targets for Influenza Drug and Vaccine Development","publication_year":2013,"publication_date":"2013-08-27","ids":{"openalex":"https://openalex.org/W2085168902","doi":"https://doi.org/10.1021/ci400421e","mag":"2085168902","pmid":"https://pubmed.ncbi.nlm.nih.gov/23980878"},"language":"en","primary_location":{"id":"doi:10.1021/ci400421e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400421e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038485246","display_name":"Muhammad Yusuf","orcid":"https://orcid.org/0000-0003-1627-1553"},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Muhammad Yusuf","raw_affiliation_strings":["Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","Pharmaceutical Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia , 11800 Minden, Pulau Pinang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"Pharmaceutical Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia , 11800 Minden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007997462","display_name":"Janez Konc","orcid":"https://orcid.org/0000-0003-0160-3375"},"institutions":[{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Janez Konc","raw_affiliation_strings":["National Institute of Chemistry, Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Chemistry, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028108064","display_name":"Choi Sy Bing","orcid":null},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Choi Sy Bing","raw_affiliation_strings":["Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","Pharmaceutical#R#Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800#R#Minden, Pulau Pinang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"Pharmaceutical#R#Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800#R#Minden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028394991","display_name":"Joanna Trykowska Konc","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Joanna Trykowska Konc","raw_affiliation_strings":["National Institute of Chemistry, Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Chemistry, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069234500","display_name":"Nurul Bahiyah Ahmad Khairudin","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nurul Bahiyah Ahmad Khairudin","raw_affiliation_strings":["Malaysian-Japan\rInternational Institute of Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia","Malaysian-Japan#R#International Institute of Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaysian-Japan\rInternational Institute of Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I4576418"]},{"raw_affiliation_string":"Malaysian-Japan#R#International Institute of Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103047859","display_name":"D. Jane\u017ei\u010d","orcid":"https://orcid.org/0000-0001-5300-5997"},"institutions":[{"id":"https://openalex.org/I118905719","display_name":"University of Primorska","ror":"https://ror.org/05xefg082","country_code":"SI","type":"education","lineage":["https://openalex.org/I118905719"]},{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Dusanka Janezic","raw_affiliation_strings":["Faculty\rfor Mathematics, Natural Sciences and Informatics, University of Primorska, Koper, Slovenia","National Institute of Chemistry, Ljubljana, Slovenia","Faculty#R#for Mathematics, Natural Sciences and Informatics, University of Primorska, Koper, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty\rfor Mathematics, Natural Sciences and Informatics, University of Primorska, Koper, Slovenia","institution_ids":["https://openalex.org/I118905719"]},{"raw_affiliation_string":"National Institute of Chemistry, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210152560"]},{"raw_affiliation_string":"Faculty#R#for Mathematics, Natural Sciences and Informatics, University of Primorska, Koper, Slovenia","institution_ids":["https://openalex.org/I118905719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008474034","display_name":"Habibah A. Wahab","orcid":"https://orcid.org/0000-0002-8353-8679"},"institutions":[{"id":"https://openalex.org/I134138859","display_name":"Ministry of Science, Technology and Innovation","ror":"https://ror.org/012s3r374","country_code":"MY","type":"government","lineage":["https://openalex.org/I134138859"]},{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Habibah A. Wahab","raw_affiliation_strings":["Malaysian\rInstitute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Halaman Bukit Gambir, 11900, Bayan Lepas, Pulau Pinang, Malaysia","Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","Malaysian#R#Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Halaman Bukit Gambir, 11900, Bayan Lepas, Pulau Pinang, Malaysia","Pharmaceutical#R#Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800#R#Minden, Pulau Pinang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaysian\rInstitute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Halaman Bukit Gambir, 11900, Bayan Lepas, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I134138859"]},{"raw_affiliation_string":"Pharmaceutical\rDesign and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800\rMinden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"Malaysian#R#Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Halaman Bukit Gambir, 11900, Bayan Lepas, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I134138859"]},{"raw_affiliation_string":"Pharmaceutical#R#Design and Simulation (PhDS) Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800#R#Minden, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103047859"],"corresponding_institution_ids":["https://openalex.org/I118905719","https://openalex.org/I4210152560"],"apc_list":null,"apc_paid":null,"fwci":1.1619,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78935386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"53","issue":"9","first_page":"2423","last_page":"2436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank (RCSB PDB)","score":0.7744866609573364},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.7235451340675354},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"Hemagglutinin (influenza)","score":0.6414664387702942},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5216360688209534},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.499950647354126},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43145763874053955},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.4174741804599762},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.41557201743125916},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.4111325740814209},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3273853659629822},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.23438969254493713},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22530758380889893},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18836921453475952},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.1740168035030365},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09670019149780273}],"concepts":[{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.7744866609573364},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.7235451340675354},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.6414664387702942},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5216360688209534},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.499950647354126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43145763874053955},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.4174741804599762},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.41557201743125916},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4111325740814209},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3273853659629822},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.23438969254493713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22530758380889893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18836921453475952},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1740168035030365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09670019149780273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400421e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400421e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23980878","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23980878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1965186869","https://openalex.org/W1970065441","https://openalex.org/W1971213794","https://openalex.org/W1971618381","https://openalex.org/W1974421522","https://openalex.org/W1978807612","https://openalex.org/W1979414133","https://openalex.org/W1979645814","https://openalex.org/W1981493449","https://openalex.org/W1983304433","https://openalex.org/W1984412128","https://openalex.org/W1984416131","https://openalex.org/W2002632348","https://openalex.org/W2004296339","https://openalex.org/W2011621675","https://openalex.org/W2013847640","https://openalex.org/W2026391844","https://openalex.org/W2028666280","https://openalex.org/W2028996285","https://openalex.org/W2031194866","https://openalex.org/W2034589465","https://openalex.org/W2040440325","https://openalex.org/W2040924627","https://openalex.org/W2041654633","https://openalex.org/W2045544697","https://openalex.org/W2049275721","https://openalex.org/W2053172092","https://openalex.org/W2053746900","https://openalex.org/W2056070442","https://openalex.org/W2056297672","https://openalex.org/W2059127260","https://openalex.org/W2060686951","https://openalex.org/W2062941476","https://openalex.org/W2063015454","https://openalex.org/W2065283382","https://openalex.org/W2076398318","https://openalex.org/W2083956673","https://openalex.org/W2085736050","https://openalex.org/W2088671419","https://openalex.org/W2096091144","https://openalex.org/W2096863497","https://openalex.org/W2098292021","https://openalex.org/W2102335249","https://openalex.org/W2109558687","https://openalex.org/W2114289644","https://openalex.org/W2119611042","https://openalex.org/W2124448263","https://openalex.org/W2124518593","https://openalex.org/W2126334238","https://openalex.org/W2128402268","https://openalex.org/W2137696599","https://openalex.org/W2138770756","https://openalex.org/W2151666126","https://openalex.org/W2152617913","https://openalex.org/W2153074293","https://openalex.org/W2154116964","https://openalex.org/W2162120660","https://openalex.org/W2162243146","https://openalex.org/W2163135112","https://openalex.org/W2164807254","https://openalex.org/W2165837267","https://openalex.org/W2168621448","https://openalex.org/W2173375845","https://openalex.org/W2468292732","https://openalex.org/W4233502330","https://openalex.org/W4251947800"],"related_works":["https://openalex.org/W2021537447","https://openalex.org/W2204875792","https://openalex.org/W2139427540","https://openalex.org/W1978036248","https://openalex.org/W2098500164","https://openalex.org/W2387678745","https://openalex.org/W2107100610","https://openalex.org/W2607478115","https://openalex.org/W2070601214","https://openalex.org/W2085168902"],"abstract_inverted_index":{"ProBiS":[0,88,109],"is":[1,46,86,110,129,137,166],"a":[2,140],"new":[3],"method":[4],"to":[5,30,106,168],"identify":[6],"the":[7,17,31,63,66,111,117,133,157,172,192],"binding":[8,40,70,119,135],"site":[9,120],"of":[10,42,68,81,183],"protein":[11],"through":[12],"local":[13,73],"structural":[14,74],"alignment":[15,75],"against":[16],"nonredundant":[18],"Protein":[19],"Data":[20],"Bank":[21],"(PDB),":[22],"which":[23,45,128],"may":[24],"result":[25],"in":[26,54,84,171,190],"unique":[27],"findings":[28],"compared":[29],"energy-based,":[32],"geometry-based,":[33],"and":[34,52,79,102,160,195],"sequence-based":[35],"predictors.":[36],"In":[37],"this":[38],"work,":[39],"sites":[41,71,93,186],"Hemagglutinin":[43],"(HA),":[44],"an":[47],"important":[48],"target":[49,144],"for":[50,145],"drugs":[51],"vaccines":[53],"influenza":[55,193],"treatment,":[56],"have":[57],"been":[58],"revisited":[59],"by":[60,72,163],"ProBiS.":[61],"For":[62],"first":[64],"time,":[65],"identification":[67],"conserved":[69,92,143,170],"across":[76],"all":[77],"subtypes":[78],"strains":[80],"HA":[82],"available":[83],"PDB":[85],"presented.":[87],"finds":[89],"three":[90,185],"distinctive":[91],"on":[94],"HA's":[95],"structure":[96],"(named":[97],"Site":[98,100,103,126,150],"1,":[99],"2,":[101,127],"3).":[104],"Compared":[105],"other":[107],"predictors,":[108],"only":[112],"one":[113],"that":[114],"accurately":[115],"defines":[116],"receptor":[118],"(Site":[121],"1).":[122],"Apart":[123],"from":[124],"that,":[125],"located":[130,152],"slightly":[131],"above":[132],"TBHQ":[134],"site,":[136],"proposed":[138],"as":[139,178],"potential":[141],"novel":[142],"membrane":[146],"fusion":[147],"inhibitor.":[148],"Lastly,":[149],"3,":[151],"around":[153],"Helix":[154],"A":[155],"at":[156],"stem":[158],"domain":[159],"recently":[161],"targeted":[162],"cross-reactive":[164],"antibodies,":[165],"predicted":[167],"be":[169],"latest":[173],"H7N9":[174],"China":[175],"2013":[176],"strain":[177],"well.":[179],"The":[180],"further":[181],"exploration":[182],"these":[184],"provides":[187],"valuable":[188],"insight":[189],"optimizing":[191],"drug":[194],"vaccine":[196],"development.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-27T08:26:11.824852","created_date":"2025-10-10T00:00:00"}