{"id":"https://openalex.org/W2006982030","doi":"https://doi.org/10.1021/ci400332e","title":"From Determinants of RUNX1/ETO Tetramerization to Small-Molecule Protein\u2013Protein Interaction Inhibitors Targeting Acute Myeloid Leukemia","display_name":"From Determinants of RUNX1/ETO Tetramerization to Small-Molecule Protein\u2013Protein Interaction Inhibitors Targeting Acute Myeloid Leukemia","publication_year":2013,"publication_date":"2013-08-19","ids":{"openalex":"https://openalex.org/W2006982030","doi":"https://doi.org/10.1021/ci400332e","mag":"2006982030","pmid":"https://pubmed.ncbi.nlm.nih.gov/23957251"},"language":"en","primary_location":{"id":"doi:10.1021/ci400332e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400332e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059633278","display_name":"A. Metz","orcid":"https://orcid.org/0000-0002-9634-9033"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Metz","raw_affiliation_strings":["Institute for Pharmaceutical\rand Medicinal Chemistry, Department of Mathematics\rand Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmaceutical\rand Medicinal Chemistry, Department of Mathematics\rand Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080106354","display_name":"Julia Schanda","orcid":"https://orcid.org/0000-0001-9301-5348"},"institutions":[{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Schanda","raw_affiliation_strings":["Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785289","display_name":"Manuel Grez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Manuel Grez","raw_affiliation_strings":["Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022261595","display_name":"Christian Wichmann","orcid":"https://orcid.org/0000-0001-5341-8804"},"institutions":[{"id":"https://openalex.org/I4210153469","display_name":"Georg Speyer Haus","ror":"https://ror.org/04xmnzw38","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210153469"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Wichmann","raw_affiliation_strings":["Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rfor Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]},{"raw_affiliation_string":"Institute#R#for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210153469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063949219","display_name":"Holger Gohlke","orcid":"https://orcid.org/0000-0001-8613-1447"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger Gohlke","raw_affiliation_strings":["Institute for Pharmaceutical\rand Medicinal Chemistry, Department of Mathematics\rand Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmaceutical\rand Medicinal Chemistry, Department of Mathematics\rand Natural Sciences, Heinrich-Heine-University, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022261595","https://openalex.org/A5063949219","https://openalex.org/A5113785289"],"corresponding_institution_ids":["https://openalex.org/I4210153469","https://openalex.org/I44260953"],"apc_list":null,"apc_paid":null,"fwci":1.4962,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8155712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"53","issue":"9","first_page":"2197","last_page":"2202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.7117127180099487},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.7085862755775452},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6610693335533142},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.5905084609985352},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.5095887184143066},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.485257625579834},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.32886070013046265},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.29364657402038574},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15023663640022278},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.13381651043891907},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.07095754146575928}],"concepts":[{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.7117127180099487},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.7085862755775452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6610693335533142},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5905084609985352},{"id":"https://openalex.org/C2778193527","wikidata":"https://www.wikidata.org/wiki/Q15320451","display_name":"RUNX1","level":4,"score":0.5095887184143066},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.485257625579834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32886070013046265},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29364657402038574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15023663640022278},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.13381651043891907},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07095754146575928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400332e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400332e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23957251","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23957251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W96520271","https://openalex.org/W201291539","https://openalex.org/W1969561477","https://openalex.org/W1972765844","https://openalex.org/W1974638435","https://openalex.org/W1975636695","https://openalex.org/W1978993203","https://openalex.org/W1979414133","https://openalex.org/W1981072394","https://openalex.org/W1986042843","https://openalex.org/W1993339363","https://openalex.org/W2000601996","https://openalex.org/W2021370489","https://openalex.org/W2027687260","https://openalex.org/W2050249118","https://openalex.org/W2051485239","https://openalex.org/W2055466504","https://openalex.org/W2056169996","https://openalex.org/W2062767772","https://openalex.org/W2066672837","https://openalex.org/W2083441741","https://openalex.org/W2084156403","https://openalex.org/W2084501039","https://openalex.org/W2085326265","https://openalex.org/W2087630722","https://openalex.org/W2089589794","https://openalex.org/W2091348112","https://openalex.org/W2101288419","https://openalex.org/W2106060578","https://openalex.org/W2107963573","https://openalex.org/W2110890687","https://openalex.org/W2129972730","https://openalex.org/W2132802776","https://openalex.org/W2135551827","https://openalex.org/W2135845643","https://openalex.org/W2136206140","https://openalex.org/W2144775933","https://openalex.org/W2150044225","https://openalex.org/W2154382529","https://openalex.org/W2168487926","https://openalex.org/W2169640519","https://openalex.org/W2176516200"],"related_works":["https://openalex.org/W2281423246","https://openalex.org/W2158819124","https://openalex.org/W1767494243","https://openalex.org/W4312084832","https://openalex.org/W2301371353","https://openalex.org/W4323364901","https://openalex.org/W2520698362","https://openalex.org/W2161922025","https://openalex.org/W4362507064","https://openalex.org/W2006982030"],"abstract_inverted_index":{"We":[0],"identified":[1],"the":[2,23,38,61],"first":[3,62],"small-molecule":[4],"protein-protein":[5,51,71],"interaction":[6,72],"inhibitors":[7],"of":[8,35,40],"RUNX1/ETO":[9],"tetramerization":[10],"applying":[11],"structure-based":[12,67],"virtual":[13],"screening":[14,28],"guided":[15],"by":[16],"predicted":[17],"hot":[18,31],"spots":[19],"and":[20],"pockets":[21],"in":[22,64],"interface.":[24],"A":[25],"3D":[26],"similarity":[27],"revealed":[29],"specific":[30],"spot":[32],"mimetics,":[33],"one":[34],"which":[36],"prevents":[37],"proliferation":[39],"RUNX1/ETO-dependent":[41],"SKNO-1":[42],"cells":[43],"at":[44],"low":[45],"micromolar":[46],"concentration.":[47],"Using":[48],"solely":[49],"a":[50],"complex":[52],"structure":[53],"to":[54,69],"start":[55],"with,":[56],"this":[57],"strategy":[58],"can":[59],"be":[60],"step":[63],"any":[65],"comparable":[66],"endeavor":[68],"identify":[70],"inhibitors.":[73]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}