{"id":"https://openalex.org/W2026712967","doi":"https://doi.org/10.1021/ci4002553","title":"Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach","display_name":"Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach","publication_year":2013,"publication_date":"2013-09-03","ids":{"openalex":"https://openalex.org/W2026712967","doi":"https://doi.org/10.1021/ci4002553","mag":"2026712967","pmid":"https://pubmed.ncbi.nlm.nih.gov/24001328"},"language":"en","primary_location":{"id":"doi:10.1021/ci4002553","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci4002553","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042899314","display_name":"Giulio Poli","orcid":"https://orcid.org/0000-0002-8061-5632"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giulio Poli","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department of Pharmacy, University of Pisa, 56126, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department of Pharmacy, University of Pisa, 56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003958577","display_name":"Tiziano Tuccinardi","orcid":null},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tiziano Tuccinardi","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029995182","display_name":"Flavio Rizzolio","orcid":"https://orcid.org/0000-0002-3400-4363"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flavio Rizzolio","raw_affiliation_strings":["Division of Experimental\rand Clinical Pharmacology, Department of Molecular Biology\rand Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","Division of Experimental#R#and Clinical Pharmacology, Department of Molecular Biology#R#and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy"],"affiliations":[{"raw_affiliation_string":"Division of Experimental\rand Clinical Pharmacology, Department of Molecular Biology\rand Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental#R#and Clinical Pharmacology, Department of Molecular Biology#R#and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015876426","display_name":"Isabella Caligiuri","orcid":"https://orcid.org/0000-0002-4355-5597"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella Caligiuri","raw_affiliation_strings":["Division of Experimental\rand Clinical Pharmacology, Department of Molecular Biology\rand Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","Division of Experimental#R#and Clinical Pharmacology, Department of Molecular Biology#R#and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy"],"affiliations":[{"raw_affiliation_string":"Division of Experimental\rand Clinical Pharmacology, Department of Molecular Biology\rand Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental#R#and Clinical Pharmacology, Department of Molecular Biology#R#and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO, Aviano, 33081 Pordenone, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083762891","display_name":"Lorenzo Botta","orcid":"https://orcid.org/0000-0002-0856-2986"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Botta","raw_affiliation_strings":["Dipartimento\rFarmaco Chimico Tecnologico, Universit\u00e0 di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento\rFarmaco Chimico Tecnologico, Universit\u00e0 di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423910","display_name":"Carlotta Granchi","orcid":"https://orcid.org/0000-0002-5849-0722"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlotta Granchi","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063884019","display_name":"Gabriella Ortore","orcid":"https://orcid.org/0000-0002-1541-6258"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Ortore","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081656760","display_name":"Filippo Minutolo","orcid":"https://orcid.org/0000-0002-3312-104X"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Minutolo","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008783082","display_name":"Silvia Schenone","orcid":"https://orcid.org/0000-0002-3286-786X"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Schenone","raw_affiliation_strings":["Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Genova, Viale Benedetto\rXV 3, 16132 Genova, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento\rdi Scienze Farmaceutiche, Universit\u00e0 degli Studi di Genova, Viale Benedetto\rXV 3, 16132 Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084587144","display_name":"Adriano Martinelli","orcid":"https://orcid.org/0000-0002-7197-0552"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Martinelli","raw_affiliation_strings":["Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department\rof Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department#R#of Pharmacy, University of Pisa, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5042899314"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":null,"apc_paid":null,"fwci":2.9003,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90623141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"53","issue":"10","first_page":"2538","last_page":"2547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fyn","display_name":"FYN","score":0.9880931973457336},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5888373851776123},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.5875461101531982},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.5853037238121033},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.473474383354187},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.44712337851524353},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3810366988182068},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33227190375328064},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3150729537010193},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30375924706459045},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.28801262378692627},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22570264339447021}],"concepts":[{"id":"https://openalex.org/C37686147","wikidata":"https://www.wikidata.org/wiki/Q423628","display_name":"FYN","level":4,"score":0.9880931973457336},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5888373851776123},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.5875461101531982},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5853037238121033},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.473474383354187},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44712337851524353},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3810366988182068},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33227190375328064},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3150729537010193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30375924706459045},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28801262378692627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22570264339447021}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/ci4002553","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci4002553","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:24001328","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24001328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/242546","is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/242546","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unige.it:11567/695767","is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/695767","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unive.it:10278/3683002","is_oa":false,"landing_page_url":"http://hdl.handle.net/10278/3683002","pdf_url":null,"source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W168147921","https://openalex.org/W1590620730","https://openalex.org/W1836956425","https://openalex.org/W1964513093","https://openalex.org/W1970745079","https://openalex.org/W1976118830","https://openalex.org/W1978171318","https://openalex.org/W1989116199","https://openalex.org/W1990524359","https://openalex.org/W1996966884","https://openalex.org/W1997619108","https://openalex.org/W2000385205","https://openalex.org/W2009557027","https://openalex.org/W2014439486","https://openalex.org/W2025632617","https://openalex.org/W2042270905","https://openalex.org/W2044822774","https://openalex.org/W2052030759","https://openalex.org/W2052203880","https://openalex.org/W2054478209","https://openalex.org/W2054612304","https://openalex.org/W2056437403","https://openalex.org/W2067191435","https://openalex.org/W2067837249","https://openalex.org/W2070756053","https://openalex.org/W2081328612","https://openalex.org/W2082620735","https://openalex.org/W2088510144","https://openalex.org/W2089168347","https://openalex.org/W2090895449","https://openalex.org/W2093764184","https://openalex.org/W2094545147","https://openalex.org/W2098759196","https://openalex.org/W2101480800","https://openalex.org/W2102827430","https://openalex.org/W2116936948","https://openalex.org/W2133348265","https://openalex.org/W2141354934","https://openalex.org/W2147554787","https://openalex.org/W2149086084","https://openalex.org/W2155049938","https://openalex.org/W2160318185","https://openalex.org/W2160398605","https://openalex.org/W2162282210","https://openalex.org/W2176625501","https://openalex.org/W2204075485","https://openalex.org/W2416546881"],"related_works":["https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W2594726310","https://openalex.org/W2055981013","https://openalex.org/W2141354934","https://openalex.org/W2355193834","https://openalex.org/W2907597838","https://openalex.org/W2033497619","https://openalex.org/W2024630630","https://openalex.org/W2116632775"],"abstract_inverted_index":{"The":[0],"abnormal":[1],"activity":[2,114],"of":[3,47,63,75,127,148],"Fyn":[4,40,97,113,153],"tyrosine":[5],"kinase":[6],"has":[7,34],"been":[8,36],"shown":[9],"to":[10,13,25,85,94,110],"be":[11,140],"related":[12],"various":[14,64],"human":[15],"cancers.":[16],"Furthermore,":[17,132],"its":[18],"involvement":[19],"in":[20,118],"signaling":[21],"pathways":[22],"that":[23,102],"lead":[24],"severe":[26],"pathologies,":[27],"such":[28],"as":[29,142],"Alzheimer's":[30],"and":[31,54,89,150],"Parkinson's":[32],"diseases,":[33],"also":[35],"demonstrated,":[37],"thus":[38],"making":[39],"an":[41],"attractive":[42],"target":[43],"for":[44,51,145],"the":[45,61,69,73,76,79,87,104,119,125,128,133,146],"discovery":[46],"potential":[48],"novel":[49],"therapeutics":[50],"brain":[52],"pathologies":[53],"tumors.":[55],"In":[56],"this":[57],"study":[58],"we":[59,130],"evaluated":[60],"reliability":[62],"screening":[65,81],"approaches":[66],"based":[67],"on":[68],"FLAP":[70],"software.":[71],"By":[72],"application":[74],"best":[77],"procedure,":[78],"virtual":[80],"workflow":[82],"was":[83],"used":[84],"filter":[86],"Gold":[88],"Platinum":[90],"database":[91],"from":[92],"Asinex":[93],"identify":[95],"new":[96,149],"inhibitors.":[98,154],"Enzymatic":[99],"assays":[100],"revealed":[101],"among":[103],"eight":[105],"top-scoring":[106],"compounds":[107,136],"five":[108,134],"proved":[109],"efficiently":[111],"inhibit":[112],"with":[115],"IC50":[116],"values":[117],"micromolar":[120],"range.":[121],"These":[122],"results":[123],"demonstrate":[124],"validity":[126],"methodologies":[129],"followed.":[131],"active":[135],"herein":[137],"described":[138],"may":[139],"considered":[141],"interesting":[143],"leads":[144],"development":[147],"more":[151],"efficient":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
