{"id":"https://openalex.org/W2075580221","doi":"https://doi.org/10.1021/ci400241s","title":"Mining the Characteristic Interaction Patterns on Protein\u2013Protein Binding Interfaces","display_name":"Mining the Characteristic Interaction Patterns on Protein\u2013Protein Binding Interfaces","publication_year":2013,"publication_date":"2013-08-10","ids":{"openalex":"https://openalex.org/W2075580221","doi":"https://doi.org/10.1021/ci400241s","mag":"2075580221","pmid":"https://pubmed.ncbi.nlm.nih.gov/23930922"},"language":"en","primary_location":{"id":"doi:10.1021/ci400241s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400241s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380453","display_name":"Yan Li","orcid":"https://orcid.org/0009-0000-9658-0545"},"institutions":[{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032 People's Republic of China"],"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032 People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100753007","display_name":"Zhihai Liu","orcid":"https://orcid.org/0000-0002-4527-8829"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihai Liu","raw_affiliation_strings":["State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613343","display_name":"Li Han","orcid":"https://orcid.org/0000-0001-9643-8725"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Han","raw_affiliation_strings":["State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005078579","display_name":"Chengke Li","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengke Li","raw_affiliation_strings":["State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016374232","display_name":"Renxiao Wang","orcid":"https://orcid.org/0000-0003-0485-0259"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}],"countries":["CN","MO"],"is_corresponding":false,"raw_author_name":"Renxiao Wang","raw_affiliation_strings":["State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","State Key Laboratory of Quality Research\rin Chinese\rMedicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Bioorganic and Natural\rProducts Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210112946","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Quality Research\rin Chinese\rMedicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People\u2019s Republic of China","institution_ids":["https://openalex.org/I111950717"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100380453"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112946"],"apc_list":null,"apc_paid":null,"fwci":1.8127,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85624133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"53","issue":"9","first_page":"2437","last_page":"2447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.7179113626480103},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.635535478591919},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5031422972679138},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4838060736656189},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4630031883716583},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4626961350440979},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.4562138617038727},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.42903873324394226},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.42252838611602783},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3938215970993042},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37792646884918213},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3305056095123291},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.32616013288497925},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2775689661502838},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2687581181526184},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23500961065292358}],"concepts":[{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.7179113626480103},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.635535478591919},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5031422972679138},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4838060736656189},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4630031883716583},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4626961350440979},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4562138617038727},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.42903873324394226},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.42252838611602783},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3938215970993042},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37792646884918213},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3305056095123291},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32616013288497925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2775689661502838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2687581181526184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23500961065292358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400241s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400241s","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23930922","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23930922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1585234850","https://openalex.org/W1974166931","https://openalex.org/W1975503494","https://openalex.org/W1978097385","https://openalex.org/W1979601325","https://openalex.org/W1990590977","https://openalex.org/W1994917529","https://openalex.org/W1999758645","https://openalex.org/W2009158642","https://openalex.org/W2014985938","https://openalex.org/W2018408116","https://openalex.org/W2031772330","https://openalex.org/W2038683465","https://openalex.org/W2055043387","https://openalex.org/W2060987758","https://openalex.org/W2069688347","https://openalex.org/W2084333983","https://openalex.org/W2091565674","https://openalex.org/W2094090446","https://openalex.org/W2096863497","https://openalex.org/W2103860090","https://openalex.org/W2106799894","https://openalex.org/W2115167726","https://openalex.org/W2116211618","https://openalex.org/W2127495252","https://openalex.org/W2130479394","https://openalex.org/W2130958268","https://openalex.org/W2135703599","https://openalex.org/W2136525667","https://openalex.org/W2141624700","https://openalex.org/W2150192011","https://openalex.org/W2162402626","https://openalex.org/W2168164063","https://openalex.org/W2170743452","https://openalex.org/W2327333505","https://openalex.org/W2518086326"],"related_works":["https://openalex.org/W2094822546","https://openalex.org/W1969080446","https://openalex.org/W4255644844","https://openalex.org/W3108941781","https://openalex.org/W2181394498","https://openalex.org/W2287132924","https://openalex.org/W2131407941","https://openalex.org/W2586268529","https://openalex.org/W2125650596","https://openalex.org/W1509891158"],"abstract_inverted_index":{"Protein-protein":[0],"interactions":[1],"are":[2,9,39,169],"observed":[3,160],"in":[4,65,154],"various":[5],"biological":[6,176],"processes.":[7,28],"They":[8],"important":[10],"for":[11,22],"understanding":[12],"the":[13,56,92,143,147,151],"underlying":[14],"molecular":[15],"mechanisms":[16],"and":[17,111,137,146],"can":[18],"be":[19],"potential":[20],"targets":[21],"developing":[23],"small-molecule":[24],"regulators":[25],"of":[26,72,84,91,150],"such":[27],"Previous":[29],"studies":[30],"suggest":[31],"that":[32,161],"certain":[33],"residues":[34,128],"on":[35,61,80,116,129],"protein-protein":[36,62,86,102,130,152,162],"binding":[37,63,87,103,131],"interfaces":[38,88,104,132,163],"\"hot":[40],"spots\".":[41],"As":[42,114],"an":[43],"extension":[44],"to":[45,54,124],"this":[46],"concept,":[47],"we":[48,158],"have":[49],"developed":[50],"a":[51,70,81],"residue-based":[52],"method":[53,121],"identify":[55],"characteristic":[57,166],"interaction":[58,98,167],"patterns":[59,99,168],"(CIPs)":[60],"interfaces,":[64],"which":[66],"each":[67],"pattern":[68],"is":[69],"cluster":[71],"four":[73],"contacting":[74],"residues.":[75],"Systematic":[76],"analysis":[77],"was":[78,122],"conducted":[79],"nonredundant":[82],"set":[83],"1,222":[85],"selected":[89],"out":[90],"entire":[93],"Protein":[94],"Data":[95],"Bank.":[96],"Favored":[97],"across":[100],"different":[101],"were":[105],"retrieved":[106],"by":[107],"considering":[108],"both":[109],"geometrical":[110],"chemical":[112],"conservations.":[113],"demonstrated":[115],"two":[117],"test":[118],"tests,":[119],"our":[120,155],"able":[123],"predict":[125],"hot":[126],"spot":[127],"with":[133,172],"good":[134],"recall":[135],"scores":[136],"acceptable":[138],"precision":[139],"scores.":[140],"By":[141],"analyzing":[142],"function":[144],"annotations":[145],"evolutionary":[148],"tree":[149],"complexes":[153],"data":[156],"set,":[157],"also":[159],"sharing":[164],"common":[165],"normally":[170],"associated":[171],"identical":[173],"or":[174],"similar":[175],"functions.":[177]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}