{"id":"https://openalex.org/W2080484941","doi":"https://doi.org/10.1021/ci400146u","title":"Modeling Compound\u2013Target Interaction Network of Traditional Chinese Medicines for Type II Diabetes Mellitus: Insight for Polypharmacology and Drug Design","display_name":"Modeling Compound\u2013Target Interaction Network of Traditional Chinese Medicines for Type II Diabetes Mellitus: Insight for Polypharmacology and Drug Design","publication_year":2013,"publication_date":"2013-06-16","ids":{"openalex":"https://openalex.org/W2080484941","doi":"https://doi.org/10.1021/ci400146u","mag":"2080484941","pmid":"https://pubmed.ncbi.nlm.nih.gov/23768230"},"language":"en","primary_location":{"id":"doi:10.1021/ci400146u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400146u","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042084472","display_name":"Sheng Tian","orcid":"https://orcid.org/0000-0003-4767-6262"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Tian","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China","Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Soochow University; Suzhou Jiangsu 215123 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Soochow University; Suzhou Jiangsu 215123 China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035944985","display_name":"Youyong Li","orcid":"https://orcid.org/0000-0002-5248-2756"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youyong Li","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380698","display_name":"Dan Li","orcid":"https://orcid.org/0000-0002-1264-5952"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103940920","display_name":"Xiaojie Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojie Xu","raw_affiliation_strings":["College of Chemistry and Molecular\rEngineering, Peking University, Beijing\r100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular\rEngineering, Peking University, Beijing\r100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643054","display_name":"Junmei Wang","orcid":"https://orcid.org/0000-0002-9607-8229"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmei Wang","raw_affiliation_strings":["Department\rof Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas,\rTexas 75390, United States","Department#R#of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas,#R#Texas 75390, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas,\rTexas 75390, United States","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department#R#of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas,#R#Texas 75390, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401688","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0002-9471-1107"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028525523","display_name":"Tingjun Hou","orcid":"https://orcid.org/0000-0001-7227-2580"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tingjun Hou","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028525523"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":4.0097,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93936327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"53","issue":"7","first_page":"1787","last_page":"1803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5775611996650696},{"id":"https://openalex.org/keywords/type-2-diabetes-mellitus","display_name":"Type 2 Diabetes Mellitus","score":0.5544723272323608},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.49651771783828735},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4897160828113556},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4891941547393799},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.45983025431632996},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4450819790363312},{"id":"https://openalex.org/keywords/drug-drug-interaction","display_name":"Drug-drug interaction","score":0.42816710472106934},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.4045184850692749},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3326031565666199},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.21936443448066711},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14088857173919678},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.09440907835960388}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5775611996650696},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5544723272323608},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49651771783828735},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4897160828113556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4891941547393799},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45983025431632996},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4450819790363312},{"id":"https://openalex.org/C2910466267","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug-drug interaction","level":3,"score":0.42816710472106934},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4045184850692749},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3326031565666199},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21936443448066711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14088857173919678},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09440907835960388}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400146u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400146u","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23768230","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23768230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6299999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W24912373","https://openalex.org/W114091730","https://openalex.org/W158474817","https://openalex.org/W169486367","https://openalex.org/W1504533062","https://openalex.org/W1544009106","https://openalex.org/W1905082515","https://openalex.org/W1966446944","https://openalex.org/W1979833590","https://openalex.org/W1983248350","https://openalex.org/W1984495457","https://openalex.org/W1984554167","https://openalex.org/W1986007273","https://openalex.org/W1988022890","https://openalex.org/W1992716708","https://openalex.org/W1993403967","https://openalex.org/W1993670854","https://openalex.org/W1994079793","https://openalex.org/W1996102244","https://openalex.org/W1996715969","https://openalex.org/W1998767819","https://openalex.org/W1999064110","https://openalex.org/W2001208580","https://openalex.org/W2002915579","https://openalex.org/W2003287316","https://openalex.org/W2005789011","https://openalex.org/W2009313526","https://openalex.org/W2011383364","https://openalex.org/W2015358632","https://openalex.org/W2019980219","https://openalex.org/W2020267609","https://openalex.org/W2023097534","https://openalex.org/W2024391251","https://openalex.org/W2027547437","https://openalex.org/W2030080091","https://openalex.org/W2031449719","https://openalex.org/W2032123459","https://openalex.org/W2033591223","https://openalex.org/W2045700145","https://openalex.org/W2046128919","https://openalex.org/W2048385870","https://openalex.org/W2048519277","https://openalex.org/W2049702067","https://openalex.org/W2053996418","https://openalex.org/W2054394892","https://openalex.org/W2054881399","https://openalex.org/W2055878543","https://openalex.org/W2060531713","https://openalex.org/W2064227933","https://openalex.org/W2064564007","https://openalex.org/W2067704526","https://openalex.org/W2069636608","https://openalex.org/W2070126063","https://openalex.org/W2071798131","https://openalex.org/W2074176940","https://openalex.org/W2074743601","https://openalex.org/W2082387026","https://openalex.org/W2083045667","https://openalex.org/W2085087376","https://openalex.org/W2089524361","https://openalex.org/W2089821948","https://openalex.org/W2093426296","https://openalex.org/W2096864392","https://openalex.org/W2096974557","https://openalex.org/W2102047788","https://openalex.org/W2102377211","https://openalex.org/W2111581388","https://openalex.org/W2120396743","https://openalex.org/W2120474415","https://openalex.org/W2122995608","https://openalex.org/W2124757426","https://openalex.org/W2129026088","https://openalex.org/W2130479394","https://openalex.org/W2131642993","https://openalex.org/W2133920756","https://openalex.org/W2139723538","https://openalex.org/W2140948740","https://openalex.org/W2141474275","https://openalex.org/W2145889895","https://openalex.org/W2146844279","https://openalex.org/W2146934512","https://openalex.org/W2147798082","https://openalex.org/W2152993057","https://openalex.org/W2153284814","https://openalex.org/W2159663874","https://openalex.org/W2161879271","https://openalex.org/W2162231409","https://openalex.org/W2162603056","https://openalex.org/W2164008320","https://openalex.org/W2166520492","https://openalex.org/W2167061733","https://openalex.org/W2168775915","https://openalex.org/W2200017991","https://openalex.org/W2473004715","https://openalex.org/W2917035490","https://openalex.org/W2952295575"],"related_works":["https://openalex.org/W3082755771","https://openalex.org/W2395332729","https://openalex.org/W2407625558","https://openalex.org/W2485789143","https://openalex.org/W2040338448","https://openalex.org/W2415873281","https://openalex.org/W2463344692","https://openalex.org/W4248267070","https://openalex.org/W2341529717","https://openalex.org/W4251539487"],"abstract_inverted_index":{"In":[0],"this":[1,264],"study,":[2],"in":[3],"order":[4],"to":[5,37,64,138,193,213,296],"elucidate":[6],"the":[7,39,45,50,55,70,93,100,113,118,129,140,147,154,164,183,186,200,218,222,230,244,273,276,284,288],"action":[8],"mechanism":[9,261],"of":[10,58,103,153,163,185,199,221,275],"traditional":[11],"Chinese":[12],"medicines":[13],"(TCMs)":[14],"that":[15,28,79,158,195,217,232],"exhibit":[16],"clinical":[17],"efficacy":[18],"for":[19,44,69,89,133,174,251,271,280,287],"type":[20],"II":[21],"diabetes":[22],"mellitus":[23],"(T2DM),":[24],"an":[25],"integrated":[26],"protocol":[27],"combines":[29],"molecular":[30,59,80,121],"docking":[31,60,81,122],"and":[32,48,61,123,128,145],"pharmacophore":[33,62,83,124],"mapping":[34,63,84,125],"was":[35],"employed":[36],"find":[38,139,194,297],"potential":[40,141,176],"inhibitors":[41,66,142,166,177,203,286],"from":[42,67,120,143],"TCM":[43,144,223,278],"T2DM-related":[46,72,239,289],"targets":[47,73,91,135,290],"establish":[49,146],"compound-target":[51,148,155],"interaction":[52,149],"network.":[53,150],"First,":[54],"prediction":[56,101],"capabilities":[57],"distinguish":[65],"noninhibitors":[68],"selected":[71],"were":[74,126,136],"evaluated.":[75],"The":[76,151,171,260],"results":[77],"show":[78],"or":[82,237],"can":[85,167],"give":[86],"satisfactory":[87],"predictions":[88,119],"most":[90],"but":[92,241],"validations":[94],"are":[95,107,210],"still":[96],"quite":[97],"necessary":[98],"because":[99],"accuracies":[102],"these":[104],"two":[105],"methods":[106],"variable":[108],"across":[109],"different":[110],"targets.":[111],"Then,":[112],"Bayesian":[114,131,187],"classifiers":[115,132],"by":[116,229,243,263],"integrating":[117],"developed,":[127],"well-validated":[130],"15":[134],"utilized":[137],"analysis":[152],"network":[156],"demonstrates":[157],"a":[159,196,268,293],"small":[160],"portion":[161],"(18.6%)":[162],"predicted":[165,201,285],"interact":[168,233],"with":[169,235,246],"multitargets.":[170],"pharmacological":[172,219],"activities":[173],"some":[175],"have":[178,204],"been":[179],"experimentally":[180],"confirmed,":[181],"highlighting":[182],"reliability":[184],"classifiers.":[188],"Besides,":[189],"it":[190],"is":[191,225],"interesting":[192],"considerable":[197],"number":[198],"multitarget":[202],"free":[205,256],"radical":[206,257],"scavenging/antioxidant":[207,258],"activities,":[208],"which":[209],"closely":[211],"related":[212],"T2DM.":[214,282,302],"It":[215],"appears":[216],"effect":[220],"formulas":[224,279],"determined":[226],"not":[227],"only":[228],"compounds":[231,245,300],"directly":[234],"one":[236],"more":[238],"targets,":[240],"also":[242],"other":[247],"supplementary":[248],"bioactivities":[249],"important":[250],"relieving":[252],"T2DM,":[253],"such":[254],"as":[255],"effects.":[259],"uncovered":[262],"study":[265],"may":[266,291],"offer":[267],"deep":[269],"insight":[270],"understanding":[272],"theory":[274],"classical":[277],"combating":[281],"Moreover,":[283],"provide":[292],"good":[294],"source":[295],"new":[298],"lead":[299],"against":[301]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}