{"id":"https://openalex.org/W2035819928","doi":"https://doi.org/10.1021/ci400003p","title":"Structural Basis for the Mutation-Induced Dysfunction of Human CYP2J2: A Computational Study","display_name":"Structural Basis for the Mutation-Induced Dysfunction of Human CYP2J2: A Computational Study","publication_year":2013,"publication_date":"2013-05-07","ids":{"openalex":"https://openalex.org/W2035819928","doi":"https://doi.org/10.1021/ci400003p","mag":"2035819928","pmid":"https://pubmed.ncbi.nlm.nih.gov/23647230"},"language":"en","primary_location":{"id":"doi:10.1021/ci400003p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400003p","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101491468","display_name":"Shan Cong","orcid":"https://orcid.org/0000-0003-0956-004X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Cong","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine\r(Ministry of Education), Shanghai Center for Systems Biomedicine,\rShanghai Jiao Tong University, Shanghai 200240, China","Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine\r(Ministry of Education), Shanghai Center for Systems Biomedicine,\rShanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102828616","display_name":"Xiaotu Ma","orcid":"https://orcid.org/0000-0002-6233-2145"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Tu Ma","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine\r(Ministry of Education), Shanghai Center for Systems Biomedicine,\rShanghai Jiao Tong University, Shanghai 200240, China","Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine\r(Ministry of Education), Shanghai Center for Systems Biomedicine,\rShanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280608","display_name":"Yixue Li","orcid":"https://orcid.org/0000-0002-1198-7176"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Xue Li","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023158032","display_name":"Jingfang Wang","orcid":"https://orcid.org/0000-0002-1355-5481"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing-Fang Wang","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008280608","https://openalex.org/A5023158032"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":1.3779,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80350109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"53","issue":"6","first_page":"1350","last_page":"1357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"Arachidonic acid","score":0.9207391738891602},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5346229672431946},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4971039593219757},{"id":"https://openalex.org/keywords/hydrogen-bond","display_name":"Hydrogen bond","score":0.4895930886268616},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.47244077920913696},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4158942401409149},{"id":"https://openalex.org/keywords/wild-type","display_name":"Wild type","score":0.41313305497169495},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.34966325759887695},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3001897633075714},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17898321151733398},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.14352333545684814}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.9207391738891602},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5346229672431946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4971039593219757},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4895930886268616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47244077920913696},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4158942401409149},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.41313305497169495},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34966325759887695},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3001897633075714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17898321151733398},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.14352333545684814},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090762","descriptor_name":"Cytochrome P-450 CYP2J2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090762","descriptor_name":"Cytochrome P-450 CYP2J2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090762","descriptor_name":"Cytochrome P-450 CYP2J2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci400003p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci400003p","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23647230","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23647230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.4699999988079071,"display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1498652161","https://openalex.org/W1606011614","https://openalex.org/W1965419967","https://openalex.org/W1967194316","https://openalex.org/W1967599882","https://openalex.org/W1968280450","https://openalex.org/W1974574308","https://openalex.org/W1979975835","https://openalex.org/W1980421543","https://openalex.org/W1983798804","https://openalex.org/W1992303064","https://openalex.org/W1992611413","https://openalex.org/W1995813003","https://openalex.org/W1997036567","https://openalex.org/W1997075839","https://openalex.org/W1998557820","https://openalex.org/W2003831539","https://openalex.org/W2007187686","https://openalex.org/W2014397762","https://openalex.org/W2014762261","https://openalex.org/W2017042860","https://openalex.org/W2018363141","https://openalex.org/W2026185422","https://openalex.org/W2029730688","https://openalex.org/W2035266068","https://openalex.org/W2037113953","https://openalex.org/W2040983594","https://openalex.org/W2044901017","https://openalex.org/W2050066735","https://openalex.org/W2052673997","https://openalex.org/W2057222141","https://openalex.org/W2057664120","https://openalex.org/W2068007832","https://openalex.org/W2071486470","https://openalex.org/W2083953556","https://openalex.org/W2089693463","https://openalex.org/W2091087315","https://openalex.org/W2093486401","https://openalex.org/W2093977379","https://openalex.org/W2100173149","https://openalex.org/W2102993309","https://openalex.org/W2104610278","https://openalex.org/W2105953302","https://openalex.org/W2106004363","https://openalex.org/W2107749303","https://openalex.org/W2109471213","https://openalex.org/W2118163167","https://openalex.org/W2118233996","https://openalex.org/W2120230374","https://openalex.org/W2124371326","https://openalex.org/W2126568266","https://openalex.org/W2126677834","https://openalex.org/W2128332459","https://openalex.org/W2129370104","https://openalex.org/W2140158011","https://openalex.org/W2141853895","https://openalex.org/W2159010139","https://openalex.org/W2159730489","https://openalex.org/W2167635982","https://openalex.org/W2326704759"],"related_works":["https://openalex.org/W1981981604","https://openalex.org/W2001968092","https://openalex.org/W2043821677","https://openalex.org/W1972022817","https://openalex.org/W214510971","https://openalex.org/W2102919876","https://openalex.org/W1969972609","https://openalex.org/W2155979471","https://openalex.org/W32217533","https://openalex.org/W2086102180"],"abstract_inverted_index":{"Arachidonic":[0],"acid":[1,6,25,91],"is":[2,92],"an":[3],"essential":[4,229],"fatty":[5],"in":[7,15,49,86,184,235],"cells,":[8],"acting":[9],"as":[10,26,125],"a":[11,27,115,126,141,185,214,236],"key":[12],"inflammatory":[13,16],"intermediate":[14],"reactions.":[17],"In":[18,95],"cardiac":[19],"tissues,":[20],"CYP2J2":[21,60,105,139],"can":[22,36],"adopt":[23],"arachidonic":[24,71,90,222],"major":[28],"substrate":[29,231],"to":[30,165,188],"produce":[31],"epoxyeicosatrienoic":[32],"acids":[33],"(EETs),":[34],"which":[35],"protect":[37],"endothelial":[38],"cells":[39],"from":[40],"ischemic":[41],"or":[42],"hypoxic":[43],"injuries":[44],"and":[45,56,64,106,110,119,148,154,168,233],"have":[46],"been":[47],"implicated":[48],"the":[50,68,79,83,87,96,103,132,137,156,162,166,175,180,190,193,198,205,218],"pathogenesis":[51],"of":[52,70,89,102,131,192,207,221],"coronary":[53],"artery":[54],"disease":[55],"hypertension.":[57],"However,":[58,224],"some":[59],"polymorphisms,":[61],"i.e.,":[62],"T143A":[63,171],"N404Y,":[65],"significantly":[66],"reduce":[67],"metabolism":[69,88],"acid.":[72,223],"Lacking":[73],"experimental":[74],"structural":[75,100,129],"data":[76],"for":[77,82,230],"CYP2J2,":[78],"detailed":[80],"mechanism":[81],"mutation-induced":[84],"dysfunction":[85],"still":[93],"unknown.":[94],"current":[97],"study,":[98],"three-dimensional":[99],"models":[101,134],"wild-type":[104,138],"two":[107],"mutants":[108],"(T143A":[109],"N404Y)":[111],"were":[112],"constructed":[113],"by":[114],"coordinate":[116],"reconstruction":[117],"approach":[118],"ab":[120],"initio":[121],"modeling":[122],"using":[123],"CYP2R1":[124],"template.":[127],"The":[128],"analysis":[130],"computational":[133],"showed":[135],"that":[136],"exhibited":[140],"typical":[142],"CYP":[143],"fold":[144],"with":[145,155,217],"12":[146],"alpha-helices":[147],"three":[149],"beta-sheets":[150],"on":[151],"one":[152],"side":[153],"heme":[157],"group":[158,220],"buried":[159],"deeply":[160],"inside":[161],"core.":[163],"Due":[164],"small":[167],"hydrophobic":[169],"side-chain,":[170],"mutation":[172,202],"could":[173,203],"destabilize":[174],"C":[176],"helix,":[177],"further":[178],"placing":[179],"water":[181,195],"access":[182],"channel":[183],"closed":[186],"state":[187],"prevent":[189],"escape":[191],"produced":[194],"molecules":[196],"during":[197],"catalytic":[199],"processes.":[200],"N404Y":[201],"reposition":[204],"side-chain":[206],"Leu(378),":[208],"making":[209],"it":[210],"no":[211],"longer":[212],"form":[213],"hydrogen":[215,226],"bond":[216,227],"carboxyl":[219],"this":[225],"was":[228],"recognition":[232],"positioning":[234],"correct":[237],"orientation.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}