{"id":"https://openalex.org/W2023850747","doi":"https://doi.org/10.1021/ci3003396","title":"Structural Determinants for the Membrane Insertion of the Transmembrane Peptide of Hemagglutinin from Influenza Virus","display_name":"Structural Determinants for the Membrane Insertion of the Transmembrane Peptide of Hemagglutinin from Influenza Virus","publication_year":2012,"publication_date":"2012-10-27","ids":{"openalex":"https://openalex.org/W2023850747","doi":"https://doi.org/10.1021/ci3003396","mag":"2023850747","pmid":"https://pubmed.ncbi.nlm.nih.gov/23101989"},"language":"en","primary_location":{"id":"doi:10.1021/ci3003396","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci3003396","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022533354","display_name":"Bruno L. Victor","orcid":"https://orcid.org/0000-0002-6472-5700"},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Bruno L. Victor","raw_affiliation_strings":["Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal"],"affiliations":[{"raw_affiliation_string":"Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017184031","display_name":"Ant\u00f3nio M. Baptista","orcid":"https://orcid.org/0000-0002-7044-1210"},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio M. Baptista","raw_affiliation_strings":["Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal"],"affiliations":[{"raw_affiliation_string":"Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025349687","display_name":"Cl\u00e1udio M. Soares","orcid":"https://orcid.org/0000-0003-1154-556X"},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cl\u00e1udio M. Soares","raw_affiliation_strings":["Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal"],"affiliations":[{"raw_affiliation_string":"Instituto de Tecnologia\rQu\u00edmica e Biol\u00f3gica,\rUniversidade Nova de Lisboa Avenida da Rep\u00fablica, EAN Apartado\r127, 2781-901 Oeiras, Portugal","institution_ids":["https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022533354"],"corresponding_institution_ids":["https://openalex.org/I83558840"],"apc_list":null,"apc_paid":null,"fwci":0.4025,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65350664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"52","issue":"11","first_page":"3001","last_page":"3012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-bilayer-fusion","display_name":"Lipid bilayer fusion","score":0.7636650800704956},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.7091660499572754},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.661112904548645},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"Hemagglutinin (influenza)","score":0.5714779496192932},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.553009569644928},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5143100023269653},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.49138322472572327},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.47801434993743896},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4561629891395569},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4433358609676361},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.4204060137271881},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.39865973591804504},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3609786033630371}],"concepts":[{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.7636650800704956},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.7091660499572754},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.661112904548645},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.5714779496192932},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.553009569644928},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5143100023269653},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49138322472572327},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.47801434993743896},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4561629891395569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4433358609676361},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4204060137271881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39865973591804504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3609786033630371},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci3003396","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci3003396","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23101989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23101989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W230978","https://openalex.org/W102599612","https://openalex.org/W255996521","https://openalex.org/W1587046941","https://openalex.org/W1965359726","https://openalex.org/W1966078827","https://openalex.org/W1968301751","https://openalex.org/W1981316697","https://openalex.org/W1985064062","https://openalex.org/W1985294387","https://openalex.org/W1986055426","https://openalex.org/W1986152551","https://openalex.org/W1993008481","https://openalex.org/W2007408986","https://openalex.org/W2010622646","https://openalex.org/W2016853791","https://openalex.org/W2017304967","https://openalex.org/W2023388639","https://openalex.org/W2026786909","https://openalex.org/W2027154929","https://openalex.org/W2033906450","https://openalex.org/W2034314076","https://openalex.org/W2035266068","https://openalex.org/W2036555144","https://openalex.org/W2053484045","https://openalex.org/W2067284235","https://openalex.org/W2069888185","https://openalex.org/W2076143881","https://openalex.org/W2081431207","https://openalex.org/W2086438974","https://openalex.org/W2088323640","https://openalex.org/W2094618682","https://openalex.org/W2096025413","https://openalex.org/W2097498028","https://openalex.org/W2103945336","https://openalex.org/W2105459766","https://openalex.org/W2106882534","https://openalex.org/W2111591241","https://openalex.org/W2123416945","https://openalex.org/W2123871914","https://openalex.org/W2124159817","https://openalex.org/W2127522551","https://openalex.org/W2135779274","https://openalex.org/W2136537803","https://openalex.org/W2143312809","https://openalex.org/W2148327043","https://openalex.org/W2148433069","https://openalex.org/W2154924036","https://openalex.org/W2155858732"],"related_works":["https://openalex.org/W3099772455","https://openalex.org/W2073882639","https://openalex.org/W3172198228","https://openalex.org/W2129301794","https://openalex.org/W1986078734","https://openalex.org/W1974240269","https://openalex.org/W2062258289","https://openalex.org/W1992657771","https://openalex.org/W2040208869","https://openalex.org/W2036123216"],"abstract_inverted_index":{"Membrane":[0],"fusion":[1,27,41,58,84,102,167],"is":[2,48,184,320],"a":[3,7,52,83,90,100,118,178,194,295,313],"process":[4],"involved":[5,163],"in":[6,141,164,189,201,222,312],"high":[8],"range":[9],"of":[10,26,34,42,51,59,62,69,75,79,92,103,113,131,137,146,173,176,196,204,213,219,282,326,331],"biological":[11],"functions,":[12],"going":[13],"from":[14],"viral":[15],"infections":[16],"to":[17,37,87,99,126,134,161,230,240,266,318,334],"neurotransmitter":[18],"release.":[19],"Fusogenic":[20],"proteins":[21],"increase":[22],"the":[23,35,38,43,57,60,63,67,70,76,93,104,108,111,114,129,132,135,138,144,165,170,174,202,211,217,242,245,267,271,274,280,323,327,332,336],"slow":[24],"rate":[25],"by":[28],"coupling":[29],"energetically":[30],"downhill":[31],"conformational":[32],"changes":[33],"protein":[36,81,133,179],"kinetically":[39],"unfavorable":[40],"membrane":[44,61,68,95,136,166,182,206,249,296],"lipid":[45],"bilayers.":[46,250],"Hemagglutinin":[47],"an":[49],"example":[50],"fusogenic":[53],"protein,":[54,333],"which":[55,122],"promotes":[56],"influenza":[64],"virus":[65],"with":[66,181],"target":[71,94],"cell.":[72],"The":[73],"N-terminus":[74],"HA2":[77],"subunit":[78,116],"this":[80,147,190,197,223],"contains":[82,117],"domain":[85,121,180,200],"described":[86,125,160],"act":[88,127],"as":[89,128],"destabilizer":[91],"bilayers,":[96,207],"leading":[97],"eventually":[98],"full":[101],"two":[105],"membranes.":[106],"On":[107],"other":[109],"hand,":[110],"C-terminus":[112],"same":[115],"helical":[119],"transmembrane":[120,198,284],"was":[123],"initially":[124],"anchor":[130],"virus.":[139],"However,":[140],"recent":[142],"years":[143],"study":[145,195],"peptide":[148,199,220,247,272,285,308],"segment":[149,246],"has":[150,157],"been":[151,159],"gaining":[152],"more":[153],"attention":[154],"since":[155],"it":[156],"also":[158,257],"be":[162],"process.":[168,225],"Yet,":[169],"structural":[171],"characterization":[172],"interaction":[175,224,243,291],"such":[177],"lipids":[183],"still":[185],"very":[186,316],"limited.":[187],"Therefore,":[188],"work,":[191],"we":[192,209,255,277,301],"present":[193],"presence":[203],"DMPC":[205],"and":[208,216,232,248,260,273,287,292],"evaluate":[210],"effect":[212,218],"several":[214,283],"mutations,":[215],"oligomerization":[221],"Our":[226],"results":[227,300],"allowed":[228],"us":[229],"identify":[231],"confirm":[233],"amino":[234],"acid":[235],"residue":[236],"motifs":[237],"that":[238,263,304],"seem":[239],"regulate":[241],"between":[244,270],"Besides":[251],"these":[252],"sequence":[253],"requirements,":[254],"have":[256],"identified":[258],"length":[259],"tilt":[261],"requirements":[262],"ultimately":[264],"contribute":[265],"hydrophobic":[268],"matching":[269],"membrane.":[275],"Additionally,":[276],"looked":[278],"at":[279],"association":[281],"segments":[286,309,337],"evaluated":[288],"their":[289],"direct":[290],"stability":[293],"inside":[294],"bilayer.":[297],"From":[298],"our":[299],"could":[302],"conclude":[303],"three":[305],"independent":[306],"TM":[307],"arrange":[310],"themselves":[311],"parallel":[314],"arrangement,":[315],"similarly":[317],"what":[319],"observed":[321],"for":[322],"C-terminal":[324],"regions":[325],"hemagglutinin":[328],"crystallographic":[329],"structure":[330],"where":[335],"are":[338],"attached.":[339]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}