{"id":"https://openalex.org/W1980421543","doi":"https://doi.org/10.1021/ci3003045","title":"Autoinhibitory Mechanism for the Mutation-Induced Impaired FGF9 Signaling","display_name":"Autoinhibitory Mechanism for the Mutation-Induced Impaired FGF9 Signaling","publication_year":2012,"publication_date":"2012-08-25","ids":{"openalex":"https://openalex.org/W1980421543","doi":"https://doi.org/10.1021/ci3003045","mag":"1980421543","pmid":"https://pubmed.ncbi.nlm.nih.gov/22920789"},"language":"en","primary_location":{"id":"doi:10.1021/ci3003045","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci3003045","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347170","display_name":"Ying W\u00e1ng","orcid":"https://orcid.org/0000-0002-8863-554X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","State Key Laboratory of Microbial Metabolism and Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","State Key Laboratory of Microbial#R#Metabolism and Department of Bioinformatics#R#and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism and Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial#R#Metabolism and Department of Bioinformatics#R#and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101467562","display_name":"Xiaolin Wu","orcid":"https://orcid.org/0000-0002-0103-5374"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Lin Wu","raw_affiliation_strings":["Department of Medical Genetics, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China","Department#R#of Medical Genetics, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025,#R#China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department#R#of Medical Genetics, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025,#R#China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041491902","display_name":"Dong\u2010Qing Wei","orcid":"https://orcid.org/0000-0003-4200-7502"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong-Qing Wei","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism and Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","State Key Laboratory of Microbial#R#Metabolism and Department of Bioinformatics#R#and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism and Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial#R#Metabolism and Department of Bioinformatics#R#and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280608","display_name":"Yixue Li","orcid":"https://orcid.org/0000-0002-1198-7176"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Xue Li","raw_affiliation_strings":["Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China","Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, China","Key Laboratory of#R#Systems Biology,#R#Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, China","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Key Laboratory of#R#Systems Biology,#R#Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023158032","display_name":"Jingfang Wang","orcid":"https://orcid.org/0000-0002-1355-5481"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing-Fang Wang","raw_affiliation_strings":["Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, China","Key Laboratory#R#of Systems Biomedicine#R#(Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, China","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Key Laboratory#R#of Systems Biomedicine#R#(Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023158032","https://openalex.org/A5041491902","https://openalex.org/A5101467562"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210162648"],"apc_list":null,"apc_paid":null,"fwci":0.3973,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60388728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"52","issue":"9","first_page":"2422","last_page":"2429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"Fibroblast growth factor","score":0.7419185638427734},{"id":"https://openalex.org/keywords/fgf9","display_name":"FGF9","score":0.6843773126602173},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.598891019821167},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5871663093566895},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.547172486782074},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48743537068367004},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"Fibroblast growth factor receptor","score":0.4830670952796936},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4346056580543518},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35807549953460693},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3453124463558197},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.30981722474098206},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14129239320755005}],"concepts":[{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.7419185638427734},{"id":"https://openalex.org/C77390185","wikidata":"https://www.wikidata.org/wiki/Q17927898","display_name":"FGF9","level":4,"score":0.6843773126602173},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.598891019821167},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5871663093566895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.547172486782074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48743537068367004},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4830670952796936},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4346056580543518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35807549953460693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3453124463558197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30981722474098206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14129239320755005},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051525","descriptor_name":"Fibroblast Growth Factor 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051525","descriptor_name":"Fibroblast Growth Factor 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051525","descriptor_name":"Fibroblast Growth Factor 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci3003045","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci3003045","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:22920789","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22920789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.75}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1499670070","https://openalex.org/W1854803455","https://openalex.org/W1967599882","https://openalex.org/W1974574308","https://openalex.org/W1974873948","https://openalex.org/W1982754899","https://openalex.org/W1986514568","https://openalex.org/W1998557820","https://openalex.org/W2014762261","https://openalex.org/W2018363141","https://openalex.org/W2018654805","https://openalex.org/W2026321358","https://openalex.org/W2034664769","https://openalex.org/W2036477971","https://openalex.org/W2038948616","https://openalex.org/W2052673997","https://openalex.org/W2053784969","https://openalex.org/W2056983875","https://openalex.org/W2062988437","https://openalex.org/W2068007832","https://openalex.org/W2078638321","https://openalex.org/W2096754487","https://openalex.org/W2099543104","https://openalex.org/W2102098049","https://openalex.org/W2102894828","https://openalex.org/W2118233996","https://openalex.org/W2118456468","https://openalex.org/W2122892477","https://openalex.org/W2134967712","https://openalex.org/W2135296230","https://openalex.org/W2141853895","https://openalex.org/W2142614266","https://openalex.org/W2149594557","https://openalex.org/W2156172361","https://openalex.org/W2166650881","https://openalex.org/W2167091901","https://openalex.org/W2167544720","https://openalex.org/W2171778773","https://openalex.org/W2393861604","https://openalex.org/W2396403180"],"related_works":["https://openalex.org/W2059244341","https://openalex.org/W4243851374","https://openalex.org/W2078638321","https://openalex.org/W2057869639","https://openalex.org/W2075500765","https://openalex.org/W4300239805","https://openalex.org/W2017952250","https://openalex.org/W1981099772","https://openalex.org/W1530921588","https://openalex.org/W2101469591"],"abstract_inverted_index":{"Fibroblast":[0],"growth":[1,11],"factor":[2,12,157],"9":[3],"(FGF9),":[4],"an":[5,103,202,243],"important":[6,244],"member":[7],"of":[8,35,68,97,105,238],"the":[9,28,36,72,95,110,114,120,126,144,148,167,189,197,222],"fibroblast":[10],"(FGF)":[13],"family,":[14],"can":[15,39,135,174],"bind":[16,195],"with":[17,58,102,196],"high":[18],"affinity":[19,162],"to":[20,55,93,142,158,180,194,200,206,233],"FGFR3":[21],"in":[22,33,49,147,166,248],"a":[23,65,130,155,177,235],"heparin-dependent":[24],"approach.":[25],"In":[26,81,187],"humans,":[27],"deletions":[29],"and":[30,44,89,100,163],"mutations":[31],"resulting":[32],"dysfunction":[34],"FGF9":[37,247],"signaling":[38,62,117,169,230],"cause":[40,67,237],"human":[41,239],"skeletal":[42],"dysplasia":[43],"cancers.":[45],"A":[46],"mutation":[47,128],"(S99N)":[48],"this":[50,76,82],"protein":[51],"has":[52,129],"been":[53],"identified":[54],"be":[56,234],"associated":[57],"significantly":[59],"impaired":[60,115,228],"FGF":[61,116,149,168,208,229],"considered":[63,153],"as":[64,141,154],"potential":[66,236],"synostoses":[69,240],"syndrome.":[70],"However,":[71],"detailed":[73,111],"mechanism":[74,112],"for":[75,113,246],"observation":[77],"still":[78],"remains":[79],"unknown.":[80],"study,":[83],"we":[84,215],"used":[85],"molecular":[86],"dynamics":[87],"simulations":[88],"free":[90,185],"energy":[91],"calculations":[92],"study":[94],"interactions":[96],"FGF9(WT/S99N),":[98],"FGFR3c,":[99],"heparin,":[101],"aim":[104],"providing":[106],"atomic":[107],"sights":[108],"into":[109],"caused":[118],"by":[119],"S99N":[121,127],"mutation.":[122],"We":[123],"found":[124],"that":[125],"well-ordered":[131],"C-terminal":[132],"structure,":[133],"which":[134,151,220],"reduce":[136],"its":[137,181],"homodimerization":[138],"ability":[139],"so":[140],"break":[143],"monomer-dimer":[145],"equilibrium":[146],"signaling,":[150],"is":[152,192,231],"key":[156],"regulate":[159],"extracellular":[160],"matrix":[161],"tissue":[164],"diffusion":[165],"pathway.":[170],"The":[171,227],"FGF9(WT)":[172],"monomer":[173,191],"preferentially":[175],"form":[176,201],"homodimer":[178],"owing":[179],"comparatively":[182],"favorable":[183],"binding":[184],"energy.":[186],"contrast,":[188],"FGF9(S99N)":[190],"preferred":[193],"FGFR3c":[198],"receptor":[199],"inactive":[203],"complex,":[204],"leading":[205],"impair":[207],"signaling.":[209],"To":[210],"support":[211],"our":[212],"computational":[213,223],"findings,":[214],"also":[216],"performed":[217],"biochemical":[218],"experiments,":[219],"confirm":[221],"results":[224],"mentioned":[225],"above.":[226],"believed":[232],"syndrome,":[241],"implicating":[242],"role":[245],"normal":[249],"joint":[250],"development.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}