{"id":"https://openalex.org/W2030839138","doi":"https://doi.org/10.1021/ci300189a","title":"Modeling the Closed and Open State Conformations of the GABA <sub>A</sub> Ion Channel - Plausible Structural Insights for Channel Gating","display_name":"Modeling the Closed and Open State Conformations of the GABA <sub>A</sub> Ion Channel - Plausible Structural Insights for Channel Gating","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2030839138","doi":"https://doi.org/10.1021/ci300189a","mag":"2030839138","pmid":"https://pubmed.ncbi.nlm.nih.gov/23116339"},"language":"en","primary_location":{"id":"doi:10.1021/ci300189a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300189a","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036989139","display_name":"Ramachandran Vijayan","orcid":"https://orcid.org/0000-0001-5788-5282"},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"R. S. K. Vijayan","raw_affiliation_strings":["Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India"],"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109190117","display_name":"Neha Trivedi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161501","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/04t67vr60","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210161501"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neha Trivedi","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research, Kolkata \u2212700\r032, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, Kolkata \u2212700\r032, India","institution_ids":["https://openalex.org/I4210161501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091473320","display_name":"Sudipendra Nath Roy","orcid":"https://orcid.org/0000-0002-0649-7770"},"institutions":[{"id":"https://openalex.org/I4210161501","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/04t67vr60","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210161501"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudipendra Nath Roy","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research, Kolkata \u2212700\r032, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, Kolkata \u2212700\r032, India","institution_ids":["https://openalex.org/I4210161501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084718010","display_name":"Indrani Bera","orcid":"https://orcid.org/0000-0003-4198-0204"},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indrani Bera","raw_affiliation_strings":["Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India"],"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043176906","display_name":"Prabu Manoharan","orcid":"https://orcid.org/0000-0003-2945-9694"},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabu Manoharan","raw_affiliation_strings":["Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India"],"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049858179","display_name":"Pavan V. Payghan","orcid":null},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pavan V. Payghan","raw_affiliation_strings":["Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India"],"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051389777","display_name":"Dhananjay Bhattacharyya","orcid":"https://orcid.org/0000-0001-9227-6490"},"institutions":[{"id":"https://openalex.org/I16019930","display_name":"Saha Institute of Nuclear Physics","ror":"https://ror.org/0491yz035","country_code":"IN","type":"facility","lineage":["https://openalex.org/I16019930"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dhananjay Bhattacharyya","raw_affiliation_strings":["Computational\rScience Division, Saha Institute of Nuclear Physics, Kolkata \u2212700\r064 India"],"affiliations":[{"raw_affiliation_string":"Computational\rScience Division, Saha Institute of Nuclear Physics, Kolkata \u2212700\r064 India","institution_ids":["https://openalex.org/I16019930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052277178","display_name":"Nanda Ghoshal","orcid":null},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nanda Ghoshal","raw_affiliation_strings":["Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India"],"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics\rDivision, CSIR - Indian Institute of Chemical Biology, Kolkata \u2212700 032, India","institution_ids":["https://openalex.org/I160344538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5036989139"],"corresponding_institution_ids":["https://openalex.org/I160344538"],"apc_list":null,"apc_paid":null,"fwci":0.6612,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69616519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"52","issue":"11","first_page":"2958","last_page":"2969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.7518230676651001},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.6173855662345886},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5561133027076721},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.4788125157356262},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.4768418073654175},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.44175368547439575},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.4016497731208801},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.22802233695983887},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13298645615577698},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12908130884170532}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.7518230676651001},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6173855662345886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5561133027076721},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4788125157356262},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4768418073654175},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44175368547439575},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4016497731208801},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.22802233695983887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13298645615577698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12908130884170532},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci300189a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300189a","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:23116339","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23116339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1491824558","https://openalex.org/W1550209048","https://openalex.org/W1965334496","https://openalex.org/W1966078827","https://openalex.org/W1974980238","https://openalex.org/W1977064941","https://openalex.org/W1977242895","https://openalex.org/W1982283505","https://openalex.org/W1983621709","https://openalex.org/W1985588649","https://openalex.org/W1986191025","https://openalex.org/W1988236102","https://openalex.org/W1994261508","https://openalex.org/W1999613945","https://openalex.org/W2002659345","https://openalex.org/W2004228538","https://openalex.org/W2008708467","https://openalex.org/W2009084960","https://openalex.org/W2013025891","https://openalex.org/W2017120126","https://openalex.org/W2027408247","https://openalex.org/W2029582401","https://openalex.org/W2029667189","https://openalex.org/W2030947664","https://openalex.org/W2031134561","https://openalex.org/W2032493626","https://openalex.org/W2034780566","https://openalex.org/W2038850516","https://openalex.org/W2041638382","https://openalex.org/W2043901383","https://openalex.org/W2045795514","https://openalex.org/W2047399603","https://openalex.org/W2048602049","https://openalex.org/W2055043387","https://openalex.org/W2058182043","https://openalex.org/W2059230624","https://openalex.org/W2064887450","https://openalex.org/W2065283382","https://openalex.org/W2067174909","https://openalex.org/W2067963143","https://openalex.org/W2068171361","https://openalex.org/W2073286007","https://openalex.org/W2078051444","https://openalex.org/W2078934466","https://openalex.org/W2081556250","https://openalex.org/W2081693079","https://openalex.org/W2081912151","https://openalex.org/W2085913208","https://openalex.org/W2091737589","https://openalex.org/W2094426376","https://openalex.org/W2097668262","https://openalex.org/W2101327053","https://openalex.org/W2107268733","https://openalex.org/W2107998520","https://openalex.org/W2115380324","https://openalex.org/W2126249062","https://openalex.org/W2127522551","https://openalex.org/W2128572087","https://openalex.org/W2129153475","https://openalex.org/W2132354058","https://openalex.org/W2132717858","https://openalex.org/W2134614351","https://openalex.org/W2143014450","https://openalex.org/W2143336421","https://openalex.org/W2277435727"],"related_works":["https://openalex.org/W2031449089","https://openalex.org/W2112596406","https://openalex.org/W2125499229","https://openalex.org/W4385304246","https://openalex.org/W4387096018","https://openalex.org/W4387096269","https://openalex.org/W4387096070","https://openalex.org/W2232251872","https://openalex.org/W4281654480","https://openalex.org/W2893981628"],"abstract_inverted_index":{"Recent":[0],"disclosure":[1],"of":[2,7,30,73,90,95,106,141,173,219,263,283],"high":[3],"resolution":[4],"crystal":[5],"structures":[6,272],"Gloeobacter":[8],"violaceus":[9],"(GLIC)":[10],"in":[11,18,51,58,110,171,190,232],"open":[12,82,192],"state":[13,20,83,172,193],"and":[14,28,33,119,137,155,194,217],"Erwinia":[15],"chrysanthemii":[16],"(ELIC)":[17],"closed":[19,79,195],"provides":[21],"newer":[22],"avenues":[23],"to":[24,80,161,205,252],"advance":[25],"our":[26],"knowledge":[27],"understanding":[29,45,69,258],"the":[31,46,70,78,81,112,126,134,139,142,166,169,174,178,182,187,191,211,220,224,228,259,264,278,284,291,295],"physiologically":[32],"pharmacologically":[34],"important":[35],"ionotropic":[36],"GABA(A)":[37,96,267,285],"ion":[38,152,175,189,268,286],"channel.":[39,269],"The":[40,104,270],"present":[41],"modeling":[42,89,249],"study":[43,250],"envisions":[44],"complex":[47],"molecular":[48],"transitions":[49],"involved":[50,231],"ionic":[52],"conductance,":[53],"which":[54],"were":[55,159],"not":[56,275],"evident":[57],"earlier":[59],"disclosed":[60],"homology":[61],"models.":[62],"In":[63],"particular,":[64],"emphasis":[65],"was":[66,97],"put":[67],"on":[68,84],"structural":[71,198,229],"basis":[72],"gating,":[74],"gating":[75,242],"transition":[76,230],"from":[77],"an":[85],"atomic":[86],"scale.":[87],"Homology":[88],"two":[91],"different":[92],"physiological":[93],"states":[94,282],"carried":[98],"out":[99],"using":[100],"their":[101],"respective":[102,296],"templates.":[103],"ability":[105],"induced":[107],"fit":[108],"docking":[109,124],"breaking":[111],"critical":[113],"inter":[114],"residue":[115],"salt":[116],"bridge":[117],"(Glu155\u03b2(2)":[118],"Arg207\u03b2(2))":[120],"upon":[121],"endogenous":[122],"GABA":[123],"reflects":[125],"perceived":[127,235],"side":[128],"chain":[129],"rearrangements":[130],"that":[131],"occur":[132],"at":[133,210],"orthosteric":[135],"site":[136],"consolidate":[138],"quality":[140],"model.":[143],"Biophysical":[144],"calculations":[145],"like":[146,165],"electrostatic":[147,179],"mapping,":[148],"pore":[149],"radius":[150],"calculation,":[151],"solvation":[153],"profile,":[154],"normal-mode":[156],"analysis":[157],"(NMA)":[158],"undertaken":[160],"address":[162],"pertinent":[163],"questions":[164],"following:":[167],"How":[168,184],"change":[170],"channel":[176,201,287],"alters":[177],"environment":[180],"across":[181],"lumen;":[183],"accessible":[185],"is":[186],"Cl(-)":[188],"state;":[196],"What":[197],"changes":[199],"regulate":[200],"gating.":[202,233],"A":[203],"\"Twist":[204],"Turn\"":[206],"global":[207,236],"motion":[208,237],"evinced":[209],"quaternary":[212],"level":[213],"accompanied":[214],"by":[215],"tilting":[216],"rotation":[218],"M2":[221],"helices":[222],"along":[223],"membrane":[225],"normal":[226],"rationalizes":[227],"This":[234],"hints":[238],"toward":[239],"a":[240,254],"conserved":[241],"mechanism":[243],"among":[244],"pLGIC.":[245],"To":[246],"paraphrase,":[247],"this":[248],"proves":[251],"be":[253],"reliable":[255],"framework":[256],"for":[257],"structure":[260],"function":[261],"relationship":[262],"hitherto":[265],"unresolved":[266],"modeled":[271],"presented":[273],"herein":[274],"only":[276],"reveal":[277],"structurally":[279],"distinct":[280],"conformational":[281],"but":[288],"also":[289],"explain":[290],"biophysical":[292],"difference":[293],"between":[294],"states.":[297]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2016-06-24T00:00:00"}
