{"id":"https://openalex.org/W2013721954","doi":"https://doi.org/10.1021/ci300135g","title":"Docking Simulation Study and Kinase Selectivity of f152A1 and Its Analogs","display_name":"Docking Simulation Study and Kinase Selectivity of f152A1 and Its Analogs","publication_year":2012,"publication_date":"2012-07-25","ids":{"openalex":"https://openalex.org/W2013721954","doi":"https://doi.org/10.1021/ci300135g","mag":"2013721954","pmid":"https://pubmed.ncbi.nlm.nih.gov/22830536"},"language":"en","primary_location":{"id":"doi:10.1021/ci300135g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300135g","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109198921","display_name":"Megumi Ikemori\u2010Kawada","orcid":null},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Megumi Ikemori-Kawada","raw_affiliation_strings":["Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki 300-2635, Japan"],"affiliations":[{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki 300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110282172","display_name":"Atsushi Inoue","orcid":null},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Inoue","raw_affiliation_strings":["Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan"],"affiliations":[{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108496577","display_name":"Masaki Goto","orcid":null},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Goto","raw_affiliation_strings":["Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan"],"affiliations":[{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021090353","display_name":"Yuan John Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan John Wang","raw_affiliation_strings":["H3 Biomedicine Inc.,300 Technology Square, Cambridge,\rMassachusetts\r02139, United States","H3 Biomedicine Inc.,300 Technology Square, Cambridge,#R#Massachusetts#R#02139, United States"],"affiliations":[{"raw_affiliation_string":"H3 Biomedicine Inc.,300 Technology Square, Cambridge,\rMassachusetts\r02139, United States","institution_ids":[]},{"raw_affiliation_string":"H3 Biomedicine Inc.,300 Technology Square, Cambridge,#R#Massachusetts#R#02139, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103402784","display_name":"Yoshiyuki Kawakami","orcid":null},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Kawakami","raw_affiliation_strings":["Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan"],"affiliations":[{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki\r300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Tsukuba Research Laboratories, 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki#R#300-2635, Japan","institution_ids":["https://openalex.org/I55881946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109198921"],"corresponding_institution_ids":["https://openalex.org/I55881946"],"apc_list":null,"apc_paid":null,"fwci":0.394,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.60600807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"52","issue":"8","first_page":"2059","last_page":"2068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moiety","display_name":"Moiety","score":0.818545401096344},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.7279410362243652},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.700495183467865},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6429687738418579},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.6263318061828613},{"id":"https://openalex.org/keywords/molecular-model","display_name":"Molecular model","score":0.5770026445388794},{"id":"https://openalex.org/keywords/selectivity","display_name":"Selectivity","score":0.5488156676292419},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.4477007985115051},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.40601256489753723}],"concepts":[{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.818545401096344},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7279410362243652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.700495183467865},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6429687738418579},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6263318061828613},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.5770026445388794},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5488156676292419},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4477007985115051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40601256489753723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci300135g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300135g","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:22830536","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22830536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W995739795","https://openalex.org/W1563080566","https://openalex.org/W1970580337","https://openalex.org/W1971572370","https://openalex.org/W1975691556","https://openalex.org/W1979046104","https://openalex.org/W1983790923","https://openalex.org/W1985588649","https://openalex.org/W1996840082","https://openalex.org/W2005111749","https://openalex.org/W2011805684","https://openalex.org/W2020293198","https://openalex.org/W2060779189","https://openalex.org/W2067960249","https://openalex.org/W2071499259","https://openalex.org/W2083526450","https://openalex.org/W2086141155","https://openalex.org/W2087047683","https://openalex.org/W2093239060","https://openalex.org/W2103921872","https://openalex.org/W2106383417","https://openalex.org/W2129153475"],"related_works":["https://openalex.org/W2376082430","https://openalex.org/W2299503928","https://openalex.org/W1480924375","https://openalex.org/W2390476533","https://openalex.org/W4210408838","https://openalex.org/W2890264855","https://openalex.org/W1967409193","https://openalex.org/W2951828435","https://openalex.org/W2362471872","https://openalex.org/W1968571103"],"abstract_inverted_index":{"f152A1":[0,11],"is":[1,29,112,136],"a":[2],"potent":[3],"inhibitor":[4],"of":[5,39,59,77,110,116,133,145,152],"MAP":[6,63],"kinases":[7,167],"and":[8,12,20,37,50,70,80,129],"TNF\u03b1-transcription.":[9],"When":[10],"its":[13],"analogs":[14],"are":[15],"assayed":[16],"against":[17],"ERK2,":[18,78],"MEK1,":[19,79],"MEKK1,":[21],"these":[22,60,153,156],"compounds":[23,61],"show":[24],"different":[25,57],"inhibition":[26],"profiles.":[27],"It":[28],"considered":[30],"that":[31,89],"the":[32,40,56,107,114,121,137,141,148],"highly":[33],"reactive":[34],"cis-enone":[35,108],"moiety":[36,109],"modifications":[38],"14-membered":[41],"resorcylic":[42],"lactone":[43],"ring":[44],"may":[45],"determine":[46],"their":[47,165],"kinase":[48],"selectivity":[49],"potency.":[51],"In":[52],"order":[53],"to":[54,164],"clarify":[55],"potencies":[58],"toward":[62],"kinases,":[64,157],"conformational":[65],"analysis,":[66],"molecular":[67,101,131,149,158],"orbital":[68,104],"studies,":[69],"docking":[71,150],"simulation":[72,127],"studies":[73,86],"using":[74],"model":[75],"structures":[76],"MEKK1":[81],"have":[82,87],"been":[83],"performed.":[84],"These":[85],"revealed":[88],"(i)":[90],"ligand":[91],"binding":[92,143],"does":[93],"not":[94],"depend":[95],"on":[96,100],"chemical":[97],"bonding":[98],"but":[99],"interaction":[102],"(molecular":[103],"analysis),":[105],"(ii)":[106],"inhibitors":[111,154],"in":[113,124,155],"range":[115],"Michael":[117],"addition":[118],"reaction":[119],"with":[120],"Cys166":[122],"residue":[123],"ERK2":[125],"(docking":[126],"study),":[128],"(iii)":[130],"shape":[132,159],"M1(8)":[134],"conformations":[135],"best":[138],"fit":[139],"for":[140],"ATP":[142],"site":[144],"kinases.":[146],"Considering":[147],"analysis":[151],"will":[160],"be":[161],"most":[162],"important":[163],"corresponding":[166],"activities.":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}