{"id":"https://openalex.org/W2040844675","doi":"https://doi.org/10.1021/ci300119c","title":"Modeling the Interface between Islet Amyloid Polypeptide and Insulin-Based Aggregation Inhibitors: Correlation to Aggregation Kinetics and Membrane Damage","display_name":"Modeling the Interface between Islet Amyloid Polypeptide and Insulin-Based Aggregation Inhibitors: Correlation to Aggregation Kinetics and Membrane Damage","publication_year":2012,"publication_date":"2012-05-03","ids":{"openalex":"https://openalex.org/W2040844675","doi":"https://doi.org/10.1021/ci300119c","mag":"2040844675","pmid":"https://pubmed.ncbi.nlm.nih.gov/22554091"},"language":"en","primary_location":{"id":"doi:10.1021/ci300119c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300119c","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048548300","display_name":"Hector Figueroa","orcid":"https://orcid.org/0000-0001-9785-8529"},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hector Figueroa","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027943545","display_name":"Durgaprasad Peddi","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Durgaprasad Peddi","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038486207","display_name":"Joshua M. Osborne","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M. Osborne","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061175396","display_name":"Brenan Wilson","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenan M. Wilson","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030626190","display_name":"Ranadheer R. Pesaru","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranadheer Reddy Pesaru","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056607338","display_name":"Balakrishna Kurva","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balakrishna Kurva","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045271616","display_name":"Swathi Ramaraju","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swathi Ramaraju","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077094147","display_name":"Maria C. Milletti","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria C. Milletti","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056293361","display_name":"Deborah Heyl","orcid":null},"institutions":[{"id":"https://openalex.org/I138216421","display_name":"Eastern Michigan University","ror":"https://ror.org/02ehshm78","country_code":"US","type":"education","lineage":["https://openalex.org/I138216421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah L. Heyl","raw_affiliation_strings":["Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States"],"affiliations":[{"raw_affiliation_string":"Chemistry Department, Eastern Michigan University, Ypsilanti, Michigan 48197, United States","institution_ids":["https://openalex.org/I138216421"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5048548300"],"corresponding_institution_ids":["https://openalex.org/I138216421"],"apc_list":null,"apc_paid":null,"fwci":0.4579,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.72060548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"52","issue":"5","first_page":"1298","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet","display_name":"Islet","score":0.8328839540481567},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.7813796997070312},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.7068490982055664},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.6247619986534119},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5843538641929626},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"Protein aggregation","score":0.5822284817695618},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5429489612579346},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4742894768714905},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3942570090293884},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25342467427253723},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17735430598258972},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17565608024597168}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8328839540481567},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7813796997070312},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.7068490982055664},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6247619986534119},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5843538641929626},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5822284817695618},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5429489612579346},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4742894768714905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3942570090293884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25342467427253723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17735430598258972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17565608024597168},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci300119c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci300119c","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:22554091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22554091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W123872719","https://openalex.org/W384984372","https://openalex.org/W647881545","https://openalex.org/W1976596880","https://openalex.org/W1976851725","https://openalex.org/W1979235421","https://openalex.org/W1980043549","https://openalex.org/W1982625489","https://openalex.org/W1984599229","https://openalex.org/W1984614201","https://openalex.org/W1984853972","https://openalex.org/W1992833081","https://openalex.org/W1993013485","https://openalex.org/W1993383767","https://openalex.org/W1998062150","https://openalex.org/W2002194503","https://openalex.org/W2006116784","https://openalex.org/W2007236469","https://openalex.org/W2010092639","https://openalex.org/W2011254772","https://openalex.org/W2015261524","https://openalex.org/W2021388785","https://openalex.org/W2023145261","https://openalex.org/W2023271753","https://openalex.org/W2030796772","https://openalex.org/W2030976617","https://openalex.org/W2038533471","https://openalex.org/W2038767330","https://openalex.org/W2039667582","https://openalex.org/W2053402937","https://openalex.org/W2056776699","https://openalex.org/W2059139141","https://openalex.org/W2061111679","https://openalex.org/W2061285367","https://openalex.org/W2074557858","https://openalex.org/W2079473982","https://openalex.org/W2079932486","https://openalex.org/W2080018640","https://openalex.org/W2083992909","https://openalex.org/W2084317099","https://openalex.org/W2085966856","https://openalex.org/W2092625134","https://openalex.org/W2100811770","https://openalex.org/W2102964261","https://openalex.org/W2115168896","https://openalex.org/W2124223881","https://openalex.org/W2143188324","https://openalex.org/W2143981217","https://openalex.org/W2145163426","https://openalex.org/W2172261176","https://openalex.org/W2230728100","https://openalex.org/W2319966366","https://openalex.org/W2331727781","https://openalex.org/W2997274473","https://openalex.org/W3004465863","https://openalex.org/W3101558973","https://openalex.org/W4242582203"],"related_works":["https://openalex.org/W2461136032","https://openalex.org/W4296503608","https://openalex.org/W1721240973","https://openalex.org/W1989584462","https://openalex.org/W3045649528","https://openalex.org/W2031696333","https://openalex.org/W1782840739","https://openalex.org/W2015068531","https://openalex.org/W2244909814","https://openalex.org/W2079403467"],"abstract_inverted_index":{"Human":[0],"islet":[1],"amyloid":[2],"polypeptide":[3],"(hIAPP)":[4],"forms":[5],"cytotoxic":[6],"fibrils":[7],"in":[8,163],"type-2":[9],"diabetes":[10],"and":[11,31,39,84,111],"insulin":[12],"is":[13,94],"known":[14],"to":[15,36,48,60,96,115,120,143],"inhibit":[16],"formation":[17],"of":[18,26,53,88,99,109,125,129,134,161],"these":[19],"aggregates.":[20],"In":[21],"this":[22,93],"study,":[23],"a":[24,100],"series":[25],"insulin-based":[27],"inhibitors":[28],"were":[29,46,58],"synthesized":[30],"assessed":[32],"for":[33],"their":[34],"ability":[35,114],"slow":[37,61],"aggregation":[38,62,149],"impact":[40],"hIAPP-induced":[41],"membrane":[42],"damage.":[43],"Computational":[44],"studies":[45],"employed":[47],"examine":[49],"the":[50,79,97,105,112,118,122,130,135,148,154,159],"underlying":[51],"mechanism":[52],"inhibition.":[54],"Overall,":[55],"all":[56],"compounds":[57],"able":[59],"at":[63,78],"sufficiently":[64],"high":[65],"concentrations":[66],"(10\u00d7":[67],"molar":[68,81],"excess);":[69],"however,":[70],"only":[71],"two":[72],"peptides":[73],"showed":[74],"any":[75],"inhibitory":[76],"capability":[77],"1:1":[80],"ratio":[82],"(EALYLV":[83],"VEALYLV).":[85],"The":[86],"results":[87],"density":[89],"functional":[90],"calculations":[91],"suggest":[92],"due":[95],"strength":[98],"salt":[101],"bridge":[102],"formed":[103],"with":[104],"Arg11":[106,119],"side":[107],"chain":[108],"hIAPP":[110],"inhibitors'":[113],"span":[116],"from":[117],"past":[121],"Phe15":[123],"residue":[124],"hIAPP,":[126],"blocking":[127],"one":[128],"principal":[131],"amyloidogenic":[132],"regions":[133],"molecule.":[136],"Unexpectedly,":[137],"slowing":[138],"fibrillogenesis":[139],"actually":[140],"increased":[141],"damage":[142],"lipid":[144],"membranes,":[145],"suggesting":[146],"that":[147],"process":[150],"itself,":[151],"rather":[152],"than":[153],"fibrilized":[155],"peptide,":[156],"may":[157],"be":[158],"cause":[160],"cytotoxicity":[162],"vivo.":[164]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}