{"id":"https://openalex.org/W2086415744","doi":"https://doi.org/10.1021/ci200278w","title":"String Kernels and High-Quality Data Set for Improved Prediction of Kinked Helices in \u03b1-Helical Membrane Proteins","display_name":"String Kernels and High-Quality Data Set for Improved Prediction of Kinked Helices in \u03b1-Helical Membrane Proteins","publication_year":2011,"publication_date":"2011-10-10","ids":{"openalex":"https://openalex.org/W2086415744","doi":"https://doi.org/10.1021/ci200278w","mag":"2086415744","pmid":"https://pubmed.ncbi.nlm.nih.gov/21981602"},"language":"en","primary_location":{"id":"doi:10.1021/ci200278w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200278w","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008591113","display_name":"Benny Kneissl","orcid":null},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benny Kneissl","raw_affiliation_strings":["Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany","Johannes Gutenberg-University of Mainz, 55128, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Johannes Gutenberg-University of Mainz, 55128, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032849513","display_name":"Sabine Mueller","orcid":"https://orcid.org/0000-0001-5184-1254"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine C. Mueller","raw_affiliation_strings":["Center for Bioinformatics, Saarland University, 66123 Saarbr\u00fccken, Germany","Intel Visual Computing Institute, Saarland University, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland University, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Intel Visual Computing Institute, Saarland University, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053568658","display_name":"Christofer S. Tautermann","orcid":"https://orcid.org/0000-0002-6935-6940"},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christofer S. Tautermann","raw_affiliation_strings":["Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany","Lead Identification and Optimization Support, Boehringer Ingelheim Pharma GmbH & Co. KG , 88397 Biberach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Lead Identification and Optimization Support, Boehringer Ingelheim Pharma GmbH & Co. KG , 88397 Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015934308","display_name":"Andreas Hildebrandt","orcid":"https://orcid.org/0000-0003-2180-6516"},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Hildebrandt","raw_affiliation_strings":["Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany","Johannes Gutenberg-University of Mainz, 55128, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Johannes Gutenberg-University of Mainz, 55128, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008591113"],"corresponding_institution_ids":["https://openalex.org/I197323543"],"apc_list":null,"apc_paid":null,"fwci":1.0492,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75793693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"51","issue":"11","first_page":"3017","last_page":"3025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5653948187828064},{"id":"https://openalex.org/keywords/string","display_name":"String (physics)","score":0.4965894818305969},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.47373831272125244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4342799484729767},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4272735118865967},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.42488616704940796},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.42399734258651733},{"id":"https://openalex.org/keywords/accessible-surface-area","display_name":"Accessible surface area","score":0.42199188470840454},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4168221354484558},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.41034549474716187},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3567466735839844},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.32368820905685425},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3056568503379822},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23497843742370605},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2131926715373993},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.15699166059494019},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12161645293235779}],"concepts":[{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5653948187828064},{"id":"https://openalex.org/C157486923","wikidata":"https://www.wikidata.org/wiki/Q1376436","display_name":"String (physics)","level":2,"score":0.4965894818305969},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.47373831272125244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4342799484729767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4272735118865967},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.42488616704940796},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.42399734258651733},{"id":"https://openalex.org/C11072593","wikidata":"https://www.wikidata.org/wiki/Q3622068","display_name":"Accessible surface area","level":2,"score":0.42199188470840454},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4168221354484558},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41034549474716187},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3567466735839844},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.32368820905685425},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3056568503379822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23497843742370605},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2131926715373993},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.15699166059494019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12161645293235779},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C37914503","wikidata":"https://www.wikidata.org/wiki/Q156495","display_name":"Mathematical physics","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci200278w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200278w","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:21981602","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21981602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1976642662","https://openalex.org/W1984514442","https://openalex.org/W1990515637","https://openalex.org/W1998134233","https://openalex.org/W2010000580","https://openalex.org/W2024211926","https://openalex.org/W2027837654","https://openalex.org/W2030947664","https://openalex.org/W2051872583","https://openalex.org/W2064281058","https://openalex.org/W2067591792","https://openalex.org/W2074266029","https://openalex.org/W2086403919","https://openalex.org/W2087001808","https://openalex.org/W2097870001","https://openalex.org/W2100890997","https://openalex.org/W2104061813","https://openalex.org/W2119168667","https://openalex.org/W2119423166","https://openalex.org/W2119821739","https://openalex.org/W2120903461","https://openalex.org/W2121950477","https://openalex.org/W2140124264","https://openalex.org/W2143015200","https://openalex.org/W2153268005","https://openalex.org/W2153606085","https://openalex.org/W2162274915","https://openalex.org/W2170711116","https://openalex.org/W2170960297","https://openalex.org/W2294798173"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2082102819","https://openalex.org/W2258323558","https://openalex.org/W2055136196","https://openalex.org/W2509172455","https://openalex.org/W2106068169","https://openalex.org/W1985444740","https://openalex.org/W1970758461","https://openalex.org/W1997263768"],"abstract_inverted_index":{"The":[0,79,141],"reasons":[1],"for":[2,91,107],"distortions":[3],"from":[4],"optimal":[5],"\u03b1-helical":[6],"geometry":[7],"are":[8,19,151],"widely":[9],"unknown,":[10],"but":[11],"their":[12,22],"influences":[13],"on":[14,137],"structural":[15,29,80],"changes":[16],"of":[17,35,43,56,65,72,123,147,154],"proteins":[18,46],"significant.":[20],"Hence,":[21],"prediction":[23,115],"is":[24],"a":[25,40,112,152],"crucial":[26],"problem":[27],"in":[28],"bioinformatics.":[30],"For":[31],"the":[32,54,62,118,156,159],"particular":[33],"case":[34],"kink":[36,77,114],"prediction,":[37],"we":[38,98],"generated":[39],"data":[41,101,160],"set":[42,102],"132":[44],"membrane":[45],"containing":[47],"1014":[48],"manually":[49],"labeled":[50],"helices":[51,125],"and":[52,67,74,93,150,158],"examined":[53],"environment":[55],"kinks.":[57],"Our":[58],"sequence":[59],"analysis":[60,81],"confirms":[61],"great":[63],"relevance":[64],"proline":[66],"reveals":[68],"disproportionately":[69],"high":[70],"occurrences":[71],"glycine":[73],"serine":[75],"at":[76],"positions.":[78],"shows":[82],"significantly":[83],"different":[84],"solvent":[85],"accessible":[86],"surface":[87],"area":[88],"mean":[89],"values":[90],"kinked":[92,131],"nonkinked":[94,133],"helices.":[95],"More":[96],"important,":[97],"used":[99],"this":[100],"to":[103],"validate":[104],"string":[105],"kernels":[106],"support":[108],"vector":[109],"machines":[110],"as":[111,130],"new":[113,119],"method.":[116],"Applying":[117],"predictor,":[120],"about":[121],"80%":[122],"all":[124],"could":[126],"be":[127],"correctly":[128],"predicted":[129],"or":[132],"even":[134],"when":[135],"focusing":[136],"small":[138],"helical":[139],"fragments.":[140],"results":[142],"exceed":[143],"recently":[144],"reported":[145],"accuracies":[146],"alternative":[148],"approaches":[149],"consequence":[153],"both":[155],"method":[157],"set.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2016-06-24T00:00:00"}