{"id":"https://openalex.org/W2016845746","doi":"https://doi.org/10.1021/ci200268y","title":"Normal Mode Analysis of Trp RNA Binding Attenuation Protein: Structure and Collective Motions","display_name":"Normal Mode Analysis of Trp RNA Binding Attenuation Protein: Structure and Collective Motions","publication_year":2011,"publication_date":"2011-08-28","ids":{"openalex":"https://openalex.org/W2016845746","doi":"https://doi.org/10.1021/ci200268y","mag":"2016845746","pmid":"https://pubmed.ncbi.nlm.nih.gov/21870865"},"language":"en","primary_location":{"id":"doi:10.1021/ci200268y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200268y","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101617943","display_name":"Guang Hu","orcid":"https://orcid.org/0000-0002-8754-1541"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guang Hu","raw_affiliation_strings":["Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083275744","display_name":"Servaas Michielssens","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Servaas Michielssens","raw_affiliation_strings":["Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027747089","display_name":"Samuel L. C. Moors","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Samuel L. C. Moors","raw_affiliation_strings":["Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007644380","display_name":"Arnout Ceulemans","orcid":"https://orcid.org/0000-0002-1288-1664"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Arnout Ceulemans","raw_affiliation_strings":["Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and INPAC Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Chemistry and INPAC-Institute for Nanoscale Physics and Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007644380"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":0.2623,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.5739477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"51","issue":"9","first_page":"2361","last_page":"2371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rigidity","display_name":"Rigidity (electromagnetism)","score":0.6750125288963318},{"id":"https://openalex.org/keywords/normal-mode","display_name":"Normal mode","score":0.6628437638282776},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.6299875974655151},{"id":"https://openalex.org/keywords/molecular-physics","display_name":"Molecular physics","score":0.5137151479721069},{"id":"https://openalex.org/keywords/molecular-vibration","display_name":"Molecular vibration","score":0.47452273964881897},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4524986147880554},{"id":"https://openalex.org/keywords/monomer","display_name":"Monomer","score":0.4349213242530823},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4268966317176819},{"id":"https://openalex.org/keywords/attenuation","display_name":"Attenuation","score":0.41095319390296936},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3286978006362915},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.28426429629325867},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.2243148684501648},{"id":"https://openalex.org/keywords/vibration","display_name":"Vibration","score":0.22361573576927185},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.18060630559921265},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1254183053970337},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1021813452243805}],"concepts":[{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.6750125288963318},{"id":"https://openalex.org/C32758168","wikidata":"https://www.wikidata.org/wiki/Q900488","display_name":"Normal mode","level":3,"score":0.6628437638282776},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.6299875974655151},{"id":"https://openalex.org/C41999313","wikidata":"https://www.wikidata.org/wiki/Q489328","display_name":"Molecular physics","level":1,"score":0.5137151479721069},{"id":"https://openalex.org/C24123453","wikidata":"https://www.wikidata.org/wiki/Q900121","display_name":"Molecular vibration","level":3,"score":0.47452273964881897},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4524986147880554},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.4349213242530823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4268966317176819},{"id":"https://openalex.org/C184652730","wikidata":"https://www.wikidata.org/wiki/Q2357982","display_name":"Attenuation","level":2,"score":0.41095319390296936},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3286978006362915},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.28426429629325867},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.2243148684501648},{"id":"https://openalex.org/C198394728","wikidata":"https://www.wikidata.org/wiki/Q3695508","display_name":"Vibration","level":2,"score":0.22361573576927185},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.18060630559921265},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1254183053970337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1021813452243805},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci200268y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200268y","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:21870865","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21870865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/11","score":0.4300000071525574,"display_name":"Sustainable cities and communities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W610636697","https://openalex.org/W1638554454","https://openalex.org/W1640152225","https://openalex.org/W1966078827","https://openalex.org/W1966419265","https://openalex.org/W1967736967","https://openalex.org/W1972148259","https://openalex.org/W1972317081","https://openalex.org/W1973535984","https://openalex.org/W1977242895","https://openalex.org/W1980155567","https://openalex.org/W1985581342","https://openalex.org/W1986507604","https://openalex.org/W1988271243","https://openalex.org/W1991762941","https://openalex.org/W1995212337","https://openalex.org/W1997310186","https://openalex.org/W2000544785","https://openalex.org/W2010956452","https://openalex.org/W2015942556","https://openalex.org/W2017716229","https://openalex.org/W2022488335","https://openalex.org/W2029667189","https://openalex.org/W2030113001","https://openalex.org/W2058700638","https://openalex.org/W2068128475","https://openalex.org/W2069123478","https://openalex.org/W2069777230","https://openalex.org/W2070701334","https://openalex.org/W2070863543","https://openalex.org/W2071656198","https://openalex.org/W2073290193","https://openalex.org/W2082462938","https://openalex.org/W2088906583","https://openalex.org/W2090067815","https://openalex.org/W2090081940","https://openalex.org/W2091765441","https://openalex.org/W2100350487","https://openalex.org/W2102449622","https://openalex.org/W2103212553","https://openalex.org/W2103649758","https://openalex.org/W2107268733","https://openalex.org/W2108700551","https://openalex.org/W2121925984","https://openalex.org/W2138979283","https://openalex.org/W2142872962","https://openalex.org/W2146598193","https://openalex.org/W2152764495","https://openalex.org/W2153304705","https://openalex.org/W2153353966","https://openalex.org/W2154623005","https://openalex.org/W2157341015","https://openalex.org/W2160451368","https://openalex.org/W2162730439","https://openalex.org/W2223938323"],"related_works":["https://openalex.org/W2084605262","https://openalex.org/W2034655915","https://openalex.org/W2094895258","https://openalex.org/W4231304883","https://openalex.org/W2088189863","https://openalex.org/W2071395489","https://openalex.org/W2042581203","https://openalex.org/W1976607746","https://openalex.org/W2020759081","https://openalex.org/W1637167642"],"abstract_inverted_index":{"The":[0,45,69,96,110],"Trp":[1,133],"RNA-binding":[2],"protein":[3],"(TRAP)":[4],"has":[5],"a":[6,10,21,128],"toroidal":[7,67],"topology":[8,120],"and":[9,66,102,119,125],"perfect":[11],"11-fold":[12],"symmetry,":[13],"which":[14,61],"makes":[15],"it":[16],"an":[17],"excellent":[18],"candidate":[19],"for":[20],"vibrational":[22,81],"study":[23,111],"of":[24,50,58,71,79,88,94,99,105,117,135],"elastic":[25,123],"properties.":[26],"Normal":[27],"mode":[28],"analysis":[29],"in":[30,43],"combination":[31],"with":[32],"correlation":[33],"matrix":[34],"calculations":[35],"was":[36],"used":[37],"to":[38],"detect":[39],"collective":[40],"low-frequency":[41,76],"motions":[42],"TRAP.":[44,95,136],"results":[46],"reveal":[47],"the":[48,55,59,64,72,75,80,85,89,103,114,122,132],"presence":[49],"highly":[51],"correlated":[52],"modes":[53],"at":[54],"lower":[56],"end":[57],"spectrum,":[60],"directly":[62],"reflect":[63],"annular":[65],"topology.":[68],"integral":[70],"correlations":[73],"over":[74],"torsional":[77],"part":[78],"spectrum":[82],"further":[83],"demonstrates":[84],"relative":[86],"rigidity":[87],"11":[90],"monomer":[91,101],"building":[92],"blocks":[93],"internal":[97],"flexibility":[98],"each":[100],"effects":[104],"Trp-binding":[106],"were":[107],"also":[108,126],"examined.":[109],"clearly":[112],"shows":[113],"determining":[115],"influence":[116],"symmetry":[118],"on":[121,131],"properties":[124],"offers":[127],"detailed":[129],"view":[130],"affinity":[134]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}