{"id":"https://openalex.org/W2056937556","doi":"https://doi.org/10.1021/ci200194w","title":"Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies","display_name":"Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies","publication_year":2011,"publication_date":"2011-06-30","ids":{"openalex":"https://openalex.org/W2056937556","doi":"https://doi.org/10.1021/ci200194w","mag":"2056937556","pmid":"https://pubmed.ncbi.nlm.nih.gov/21714567"},"language":"en","primary_location":{"id":"doi:10.1021/ci200194w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200194w","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043998755","display_name":"Anthony K. Felts","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony K. Felts","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061169323","display_name":"Krystal LaBarge","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystal LaBarge","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028372834","display_name":"Joseph D. Bauman","orcid":"https://orcid.org/0000-0002-4373-7673"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Bauman","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108465937","display_name":"Dishaben V. Patel","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dishaben V. Patel","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012330774","display_name":"D.M. Himmel","orcid":"https://orcid.org/0000-0001-6262-7130"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Himmel","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076685416","display_name":"Eddy Arnold","orcid":"https://orcid.org/0000-0003-2612-9622"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddy Arnold","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046130939","display_name":"Michael A. Parniak","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Parniak","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033874771","display_name":"Ronald M. Levy","orcid":"https://orcid.org/0000-0001-8696-5177"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Levy","raw_affiliation_strings":["BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute for Quantitative Biology, \u2021Department of Chemistry and Chemical Biology, and \u2225Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Structural Biology and \u22a5Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Bridgeside Point 2, Suite 414 450 Technology Drive Pittsburgh, Pennsylvania 15219, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5043998755"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170201317","https://openalex.org/I4210098931"],"apc_list":null,"apc_paid":null,"fwci":2.2149,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.87783376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"51","issue":"8","first_page":"1986","last_page":"1998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-h","display_name":"RNase H","score":0.7489264011383057},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.7484564781188965},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.7212415337562561},{"id":"https://openalex.org/keywords/ribonuclease","display_name":"Ribonuclease","score":0.7040450572967529},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6532133221626282},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.6356245279312134},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6139729619026184},{"id":"https://openalex.org/keywords/rnase-p","display_name":"RNase P","score":0.5965584516525269},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.49111244082450867},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.4881227910518646},{"id":"https://openalex.org/keywords/natural-product","display_name":"Natural product","score":0.4784988462924957},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"Reverse transcriptase","score":0.47124797105789185},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.46431872248649597},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.45925208926200867}],"concepts":[{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.7489264011383057},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.7484564781188965},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.7212415337562561},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.7040450572967529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6532133221626282},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6356245279312134},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6139729619026184},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.5965584516525269},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49111244082450867},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4881227910518646},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.4784988462924957},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.47124797105789185},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.46431872248649597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45925208926200867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ci200194w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200194w","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:21714567","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21714567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:alma.01RUT_INST:11663607490004646","is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Identification-of-Alternative-Binding-Sites-for/991031654916804646","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2424917","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3159817","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1551465067","https://openalex.org/W1605578858","https://openalex.org/W1964762930","https://openalex.org/W1967309605","https://openalex.org/W1969090927","https://openalex.org/W1969370763","https://openalex.org/W1984711712","https://openalex.org/W1989893427","https://openalex.org/W1991492628","https://openalex.org/W1994957764","https://openalex.org/W1995206879","https://openalex.org/W1999491936","https://openalex.org/W1999889673","https://openalex.org/W2000081716","https://openalex.org/W2004689820","https://openalex.org/W2008295611","https://openalex.org/W2011153626","https://openalex.org/W2011759021","https://openalex.org/W2014276094","https://openalex.org/W2015907087","https://openalex.org/W2018408116","https://openalex.org/W2019103398","https://openalex.org/W2023487690","https://openalex.org/W2025259834","https://openalex.org/W2025458374","https://openalex.org/W2029667189","https://openalex.org/W2030926399","https://openalex.org/W2031991206","https://openalex.org/W2033368634","https://openalex.org/W2033478986","https://openalex.org/W2035892275","https://openalex.org/W2039709045","https://openalex.org/W2050472095","https://openalex.org/W2050965916","https://openalex.org/W2051381895","https://openalex.org/W2054881399","https://openalex.org/W2057448926","https://openalex.org/W2057455648","https://openalex.org/W2063387690","https://openalex.org/W2067929442","https://openalex.org/W2072479556","https://openalex.org/W2076044287","https://openalex.org/W2078861644","https://openalex.org/W2078959398","https://openalex.org/W2079953901","https://openalex.org/W2086402826","https://openalex.org/W2093426296","https://openalex.org/W2095501702","https://openalex.org/W2097439929","https://openalex.org/W2099681431","https://openalex.org/W2102377211","https://openalex.org/W2103935162","https://openalex.org/W2104960492","https://openalex.org/W2106635136","https://openalex.org/W2107499525","https://openalex.org/W2112101018","https://openalex.org/W2117888214","https://openalex.org/W2121895929","https://openalex.org/W2124074156","https://openalex.org/W2130479394","https://openalex.org/W2133641393","https://openalex.org/W2133773344","https://openalex.org/W2134952459","https://openalex.org/W2140407975","https://openalex.org/W2144029907","https://openalex.org/W2151942123","https://openalex.org/W2159266419","https://openalex.org/W2165978291","https://openalex.org/W2270057742","https://openalex.org/W2485088577","https://openalex.org/W2949504121"],"related_works":["https://openalex.org/W2807118377","https://openalex.org/W2022060139","https://openalex.org/W2801209660","https://openalex.org/W347627768","https://openalex.org/W2056937556","https://openalex.org/W1901866580","https://openalex.org/W2028510535","https://openalex.org/W2143540931","https://openalex.org/W2171026144","https://openalex.org/W1967582118"],"abstract_inverted_index":{"The":[0,21,73],"ribonuclease":[1],"H":[2,32,144],"(RNase":[3],"H)":[4],"domain":[5,145],"on":[6,83,108],"the":[7,70,91,135,138,142],"p66":[8],"monomer":[9],"of":[10,40,56,69,86,93,110,115,121],"HIV-1":[11],"reverse":[12],"transcriptase":[13],"enzyme":[14],"has":[15],"become":[16],"a":[17,38,113,118],"target":[18],"for":[19],"inhibition.":[20],"active":[22,127],"site":[23,106],"is":[24],"one":[25],"potential":[26,45],"binding":[27,47,50,71,80],"site,":[28],"but":[29],"other":[30],"RNase":[31,143],"sites":[33,48],"can":[34],"accommodate":[35],"inhibitors.":[36],"Using":[37],"combination":[39],"experimental":[41,62],"and":[42,49,141],"computational":[43],"studies,":[44],"new":[46],"modes":[51],"have":[52],"been":[53],"identified.":[54],"Libraries":[55],"compounds":[57,74,128],"were":[58,75,129],"screened":[59],"with":[60],"an":[61,102],"assay":[63],"to":[64,90,101],"identify":[65],"actives":[66,88],"without":[67],"knowledge":[68],"site.":[72],"computationally":[76],"docked":[77],"at":[78,134],"putative":[79],"sites.":[81],"Based":[82],"positive":[84,122],"enrichment":[85,123],"natural-product":[87],"relative":[89],"database":[92],"compounds,":[94,117],"we":[95],"propose":[96],"that":[97],"many":[98],"inhibitors":[99],"bind":[100],"alternative,":[103],"potentially":[104],"allosteric,":[105],"centered":[107],"Q507":[109],"p66.":[111],"For":[112],"series":[114],"hydrazone":[116],"small":[119],"amount":[120],"was":[124],"obtained":[125],"when":[126],"bound":[130],"by":[131],"induced-fit":[132],"docking":[133],"interface":[136],"between":[137],"DNA:RNA":[139],"substrate":[140],"near":[146],"residue":[147],"Q500.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
