{"id":"https://openalex.org/W2013847640","doi":"https://doi.org/10.1021/ci200112b","title":"Long-Range Effects of a Peripheral Mutation on the Enzymatic Activity of Cytochrome P450 1A2","display_name":"Long-Range Effects of a Peripheral Mutation on the Enzymatic Activity of Cytochrome P450 1A2","publication_year":2011,"publication_date":"2011-05-07","ids":{"openalex":"https://openalex.org/W2013847640","doi":"https://doi.org/10.1021/ci200112b","mag":"2013847640","pmid":"https://pubmed.ncbi.nlm.nih.gov/21598960"},"language":"en","primary_location":{"id":"doi:10.1021/ci200112b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200112b","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100375886","display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0003-1079-5364"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University), Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai Minhang District, China 200240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University), Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai Minhang District, China 200240","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073585518","display_name":"Limin Angela Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Limin Angela Liu","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, Washington, United States 98109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, United States 98109","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089054133","display_name":"David F. Lewis","orcid":"https://orcid.org/0000-0002-1545-4553"},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David F. V. Lewis","raw_affiliation_strings":["Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, U.K","Faculty of Health and Medical Sciences , University of Surrey , Guildford GU2 7XH , U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, U.K","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"Faculty of Health and Medical Sciences , University of Surrey , Guildford GU2 7XH , U.K","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041491902","display_name":"Dong\u2010Qing Wei","orcid":"https://orcid.org/0000-0003-4200-7502"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong-Qing Wei","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University), Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai Minhang District, China 200240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University), Luc Montagnier Biomedical Research Institute, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai Minhang District, China 200240","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041491902","https://openalex.org/A5073585518"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210089486"],"apc_list":null,"apc_paid":null,"fwci":5.9097,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.95282341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"51","issue":"6","first_page":"1336","last_page":"1346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.7594881653785706},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6190557479858398},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.6127009987831116},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.555124819278717},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"Cytochrome P450","score":0.5396774411201477},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4449474811553955},{"id":"https://openalex.org/keywords/enzyme-assay","display_name":"Enzyme assay","score":0.42919921875},{"id":"https://openalex.org/keywords/mutant-protein","display_name":"Mutant protein","score":0.4235970377922058},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.36038264632225037},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3414663076400757},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3231840133666992},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15125927329063416}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.7594881653785706},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6190557479858398},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6127009987831116},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.555124819278717},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5396774411201477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449474811553955},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.42919921875},{"id":"https://openalex.org/C2779926675","wikidata":"https://www.wikidata.org/wiki/Q6943700","display_name":"Mutant protein","level":4,"score":0.4235970377922058},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36038264632225037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3414663076400757},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3231840133666992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15125927329063416}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci200112b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200112b","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:21598960","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21598960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:epubs.surrey.ac.uk:824281","is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/824281/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46000000834465027}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W15000766","https://openalex.org/W1545078134","https://openalex.org/W1747519124","https://openalex.org/W1864025888","https://openalex.org/W1923129209","https://openalex.org/W1971618381","https://openalex.org/W1974138195","https://openalex.org/W1974635207","https://openalex.org/W1991764480","https://openalex.org/W1997526676","https://openalex.org/W1997592869","https://openalex.org/W2000966246","https://openalex.org/W2003222087","https://openalex.org/W2005474992","https://openalex.org/W2008708467","https://openalex.org/W2009123297","https://openalex.org/W2019732485","https://openalex.org/W2021232512","https://openalex.org/W2023372894","https://openalex.org/W2025753091","https://openalex.org/W2027909722","https://openalex.org/W2029667189","https://openalex.org/W2035091931","https://openalex.org/W2035330965","https://openalex.org/W2038300629","https://openalex.org/W2042757390","https://openalex.org/W2046031771","https://openalex.org/W2049480378","https://openalex.org/W2051649196","https://openalex.org/W2057415024","https://openalex.org/W2062266108","https://openalex.org/W2064184077","https://openalex.org/W2066697471","https://openalex.org/W2068573594","https://openalex.org/W2069518737","https://openalex.org/W2070536631","https://openalex.org/W2070630890","https://openalex.org/W2071537307","https://openalex.org/W2072507355","https://openalex.org/W2074129172","https://openalex.org/W2075903510","https://openalex.org/W2083975423","https://openalex.org/W2088820058","https://openalex.org/W2094817406","https://openalex.org/W2095420958","https://openalex.org/W2105041993","https://openalex.org/W2105902442","https://openalex.org/W2108508060","https://openalex.org/W2111729275","https://openalex.org/W2112958646","https://openalex.org/W2113971181","https://openalex.org/W2114746663","https://openalex.org/W2115152262","https://openalex.org/W2115459289","https://openalex.org/W2118163167","https://openalex.org/W2120885049","https://openalex.org/W2126748047","https://openalex.org/W2127290087","https://openalex.org/W2128574216","https://openalex.org/W2131080603","https://openalex.org/W2132629607","https://openalex.org/W2138770756","https://openalex.org/W2140656258","https://openalex.org/W2144992831","https://openalex.org/W2146453159","https://openalex.org/W2155080119","https://openalex.org/W2158534713","https://openalex.org/W2166757428","https://openalex.org/W2167832671","https://openalex.org/W2179038264","https://openalex.org/W4251183219"],"related_works":["https://openalex.org/W2939998722","https://openalex.org/W2169750653","https://openalex.org/W2195592873","https://openalex.org/W1971782741","https://openalex.org/W3005062988","https://openalex.org/W2075777827","https://openalex.org/W4211217675","https://openalex.org/W2592466923","https://openalex.org/W1555254413","https://openalex.org/W2111034823"],"abstract_inverted_index":{"The":[0],"human":[1],"cytochrome":[2],"P450":[3],"1A2":[4,41],"is":[5,101],"an":[6],"important":[7],"drug":[8,151],"metabolizing":[9],"and":[10,60,80,110,127,137,144,150],"procarcinogen":[11],"activating":[12],"enzyme.":[13],"An":[14],"experimental":[15],"study":[16],"found":[17,64],"that":[18,65,85,104],"a":[19,33,75,81,121],"peripheral":[20],"mutation,":[21],"F186L,":[22],"at":[23],"\u223c26":[24],"\u00c5":[25],"away":[26],"from":[27],"the":[28,37,49,66,70,87,97,102],"enzyme's":[29],"active":[30,142],"site,":[31],"caused":[32,86],"significant":[34],"reduction":[35],"in":[36,77,96,120],"enzymatic":[38],"activity":[39],"of":[40,51,69,117],"deethylation":[42],"reactions.":[43],"In":[44],"this":[45,52],"paper,":[46],"we":[47],"explored":[48],"effects":[50,68],"mutation":[53,72],"by":[54],"carrying":[55],"out":[56],"molecular":[57],"dynamics":[58],"simulations":[59],"structural":[61,125],"analyses.":[62],"We":[63],"long-range":[67],"F186L":[71],"were":[73],"through":[74],"change":[76],"protein":[78,83,111,148],"flexibility":[79],"collective":[82],"motion":[84,112],"main":[88],"substrate":[89],"access":[90,107],"channel":[91,108],"to":[92,114,133],"be":[93,131],"mostly":[94],"closed":[95],"mutant.":[98],"Our":[99],"work":[100],"first":[103],"combined":[105],"both":[106],"analysis":[109,113,128],"elucidate":[115],"mechanisms":[116],"mutation-induced":[118],"allostery":[119],"CYP":[122,135],"protein.":[123],"Such":[124],"modeling":[126],"approaches":[129],"may":[130,145],"applied":[132],"other":[134,138],"proteins":[136],"enzymes":[139],"with":[140],"buried":[141],"sites":[143],"help":[146],"guide":[147],"engineering":[149],"design.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}