{"id":"https://openalex.org/W2057267661","doi":"https://doi.org/10.1021/ci200062e","title":"Aromatic\u2013Aromatic Interactions in Proteins: Beyond the Dimer","display_name":"Aromatic\u2013Aromatic Interactions in Proteins: Beyond the Dimer","publication_year":2011,"publication_date":"2011-06-11","ids":{"openalex":"https://openalex.org/W2057267661","doi":"https://doi.org/10.1021/ci200062e","mag":"2057267661","pmid":"https://pubmed.ncbi.nlm.nih.gov/21662246"},"language":"en","primary_location":{"id":"doi:10.1021/ci200062e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200062e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060622294","display_name":"Esteban Lanzarotti","orcid":null},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Esteban Lanzarotti","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028951993","display_name":"Rolf Biekofsky","orcid":null},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Rolf R. Biekofsky","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027457760","display_name":"Dar\u00edo A. Estr\u0131\u0301n","orcid":"https://orcid.org/0000-0002-5006-7225"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dar\u00edo A. Estrin","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089022257","display_name":"Marcelo A. Mart\u00ed","orcid":"https://orcid.org/0000-0002-7911-9340"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Marcelo A. Marti","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035789659","display_name":"Adri\u00e1n G. Turjanski","orcid":"https://orcid.org/0000-0003-2190-137X"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Adri\u00e1n G. Turjanski","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica and \u2021Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires, C1428EHA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035789659","https://openalex.org/A5089022257"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"],"apc_list":null,"apc_paid":null,"fwci":3.8928,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.94678732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"51","issue":"7","first_page":"1623","last_page":"1633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7594735622406006},{"id":"https://openalex.org/keywords/trimer","display_name":"Trimer","score":0.7433620095252991},{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.638176679611206},{"id":"https://openalex.org/keywords/aromaticity","display_name":"Aromaticity","score":0.591877818107605},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5297580361366272},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4760458469390869},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.43344181776046753},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.42481228709220886},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.423259437084198},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.41955411434173584},{"id":"https://openalex.org/keywords/aromatic-amino-acids","display_name":"Aromatic amino acids","score":0.4190279543399811},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.36214888095855713},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3291749954223633},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.10821560025215149},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.10449621081352234},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09420010447502136},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.06541359424591064}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7594735622406006},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.7433620095252991},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.638176679611206},{"id":"https://openalex.org/C192386470","wikidata":"https://www.wikidata.org/wiki/Q210390","display_name":"Aromaticity","level":3,"score":0.591877818107605},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5297580361366272},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4760458469390869},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.43344181776046753},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.42481228709220886},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.423259437084198},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41955411434173584},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.4190279543399811},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.36214888095855713},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3291749954223633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10821560025215149},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10449621081352234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09420010447502136},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06541359424591064},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006841","descriptor_name":"Hydrocarbons, Aromatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006841","descriptor_name":"Hydrocarbons, Aromatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006841","descriptor_name":"Hydrocarbons, Aromatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci200062e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci200062e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:21662246","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21662246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W104793819","https://openalex.org/W174644880","https://openalex.org/W1565582771","https://openalex.org/W1920130372","https://openalex.org/W1968739541","https://openalex.org/W1970769480","https://openalex.org/W1983729784","https://openalex.org/W1994272924","https://openalex.org/W1995752375","https://openalex.org/W1997858357","https://openalex.org/W2007701663","https://openalex.org/W2014437277","https://openalex.org/W2017520051","https://openalex.org/W2021937122","https://openalex.org/W2024142216","https://openalex.org/W2025524908","https://openalex.org/W2027773741","https://openalex.org/W2031969781","https://openalex.org/W2036239645","https://openalex.org/W2041760272","https://openalex.org/W2042259662","https://openalex.org/W2052366943","https://openalex.org/W2063734425","https://openalex.org/W2066695841","https://openalex.org/W2071467721","https://openalex.org/W2071818509","https://openalex.org/W2076848430","https://openalex.org/W2077617078","https://openalex.org/W2081402611","https://openalex.org/W2081941928","https://openalex.org/W2094186244","https://openalex.org/W2108044622","https://openalex.org/W2110498021","https://openalex.org/W2112457863","https://openalex.org/W2116570139","https://openalex.org/W2117077088","https://openalex.org/W2118233996","https://openalex.org/W2118270944","https://openalex.org/W2118507670","https://openalex.org/W2121520117","https://openalex.org/W2148085594","https://openalex.org/W2149162117","https://openalex.org/W2149893493","https://openalex.org/W2161732286","https://openalex.org/W2163407325","https://openalex.org/W2165716111","https://openalex.org/W2166744107","https://openalex.org/W2172712627","https://openalex.org/W4235848672"],"related_works":["https://openalex.org/W4281559067","https://openalex.org/W2260493136","https://openalex.org/W2113188411","https://openalex.org/W2976965029","https://openalex.org/W2382178265","https://openalex.org/W2055827177","https://openalex.org/W2072666835","https://openalex.org/W4248706500","https://openalex.org/W1999927713","https://openalex.org/W2939859775"],"abstract_inverted_index":{"Aromatic":[0],"residues":[1,31,82],"are":[2,97,112,128],"key":[3],"widespread":[4],"elements":[5],"of":[6,27,29,80,101,183],"protein":[7,39,67,190],"structures":[8,68],"and":[9,22,53,88,125,142,145,154,173,193],"have":[10,34,65],"been":[11,35],"shown":[12],"to":[13,45,77],"be":[14],"important":[15],"for":[16,120],"structure":[17,133],"stability,":[18,192],"folding,":[19],"protein-protein":[20,174],"recognition,":[21],"ligand":[23,194],"binding.":[24],"The":[25],"interactions":[26],"pairs":[28],"aromatic":[30,42,81,167,184],"(aromatic":[32],"dimers)":[33],"extensively":[36,138],"studied":[37],"in":[38,70,75,83,99,123,171,189],"structures.":[40,59],"Isolated":[41],"molecules":[43],"tend":[44],"form":[46],"higher":[47],"order":[48,76],"clusters,":[49],"like":[50],"trimers,":[51],"tetramers,":[52],"pentamers,":[54],"that":[55,94,109,126],"adopt":[56],"particular":[57],"well-defined":[58],"Taking":[60],"this":[61],"into":[62],"account,":[63],"we":[64,165],"surveyed":[66],"deposited":[69],"the":[71,110,115,140,181,187],"Protein":[72],"Data":[73],"Bank":[74],"find":[78],"clusters":[79,96,111,122,185],"proteins":[84,105],"larger":[85,95],"than":[86],"dimers":[87],"characterized":[89],"them.":[90],"Our":[91],"results":[92],"show":[93,166],"found":[98,119,146],"one":[100],"every":[102],"two":[103,147],"unique":[104],"crystallized":[106],"so":[107],"far,":[108],"built":[113],"adopting":[114],"same":[116],"trimer":[117],"motifs":[118],"benzene":[121],"vacuum,":[124],"they":[127],"clearly":[129],"nonlocal":[130],"brining":[131],"primary":[132],"distant":[134],"sites":[135],"together.":[136],"We":[137],"analyze":[139],"trimers":[141],"tetramers":[143],"conformations":[144],"main":[148],"cluster":[149,153],"types:":[150],"a":[151,162],"symmetric":[152],"an":[155],"extended":[156],"ladder.":[157],"Finally,":[158],"using":[159],"calmodulin":[160],"as":[161],"test":[163],"case,":[164],"clsuters":[168],"possible":[169],"role":[170],"folding":[172],"interactions.":[175],"All":[176],"together,":[177],"our":[178],"study":[179],"highlights":[180],"relevance":[182],"beyond":[186],"dimer":[188],"function,":[191],"recognition.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}