{"id":"https://openalex.org/W2173705083","doi":"https://doi.org/10.1021/ci060099e","title":"Characterization of DNA Primary Sequences by a New Similarity/Diversity Measure Based on the Partial Ordering","display_name":"Characterization of DNA Primary Sequences by a New Similarity/Diversity Measure Based on the Partial Ordering","publication_year":2006,"publication_date":"2006-08-24","ids":{"openalex":"https://openalex.org/W2173705083","doi":"https://doi.org/10.1021/ci060099e","mag":"2173705083","pmid":"https://pubmed.ncbi.nlm.nih.gov/16995720"},"language":"en","primary_location":{"id":"doi:10.1021/ci060099e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci060099e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032671962","display_name":"Roberto Todeschini","orcid":"https://orcid.org/0000-0002-6454-4192"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"R. Todeschini","raw_affiliation_strings":["Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043814662","display_name":"Viviana Consonni","orcid":"https://orcid.org/0000-0001-6252-9805"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Consonni","raw_affiliation_strings":["Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103118718","display_name":"Andrea Mauri","orcid":"https://orcid.org/0000-0002-1966-4347"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Mauri","raw_affiliation_strings":["Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080605090","display_name":"Davide Ballabio","orcid":"https://orcid.org/0000-0002-5748-147X"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Ballabio","raw_affiliation_strings":["Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Milano Chemometrics & QSAR Research Group, Department of Environmental Sciences, University of MilanoBicocca, P.za della Scienza 1, 20126 Milano, Italy, and Department of Food Science and Technologies, University of Milan, via Celoria, 2-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032671962"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I66752286"],"apc_list":null,"apc_paid":null,"fwci":2.7395,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.89341651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"46","issue":"5","first_page":"1905","last_page":"1911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13297","display_name":"History and advancements in chemistry","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13297","display_name":"History and advancements in chemistry","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.7971993684768677},{"id":"https://openalex.org/keywords/characterization","display_name":"Characterization (materials science)","score":0.7743304967880249},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5950619578361511},{"id":"https://openalex.org/keywords/primary","display_name":"Primary (astronomy)","score":0.5279720425605774},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.48291441798210144},{"id":"https://openalex.org/keywords/similarity-measure","display_name":"Similarity measure","score":0.4822857677936554},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4451074004173279},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4213629961013794},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3308323621749878},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3081408441066742},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.29130426049232483},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27871209383010864},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2488269805908203},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23987337946891785},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.12773099541664124},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.10256427526473999},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09646764397621155},{"id":"https://openalex.org/keywords/sociology","display_name":"Sociology","score":0.09227880835533142}],"concepts":[{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.7971993684768677},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.7743304967880249},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5950619578361511},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.5279720425605774},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.48291441798210144},{"id":"https://openalex.org/C2776517306","wikidata":"https://www.wikidata.org/wiki/Q29017317","display_name":"Similarity measure","level":2,"score":0.4822857677936554},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4451074004173279},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4213629961013794},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3308323621749878},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3081408441066742},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.29130426049232483},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27871209383010864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2488269805908203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23987337946891785},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12773099541664124},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10256427526473999},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09646764397621155},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.09227880835533142},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci060099e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci060099e","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:16995720","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16995720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:boa.unimib.it:10281/2725","is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/2725","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W623814603","https://openalex.org/W1485517985","https://openalex.org/W1545231783","https://openalex.org/W1967170213","https://openalex.org/W1977610286","https://openalex.org/W2011306251","https://openalex.org/W2021212550","https://openalex.org/W2033523545"],"related_works":["https://openalex.org/W2319693127","https://openalex.org/W1983228818","https://openalex.org/W2163064108","https://openalex.org/W2072263576","https://openalex.org/W2474567666","https://openalex.org/W2767257176","https://openalex.org/W2915154372","https://openalex.org/W1940044583","https://openalex.org/W1605984447","https://openalex.org/W2806903871"],"abstract_inverted_index":{"The":[0,93],"similarity/diversity":[1,31,150],"measures":[2],"play":[3],"a":[4,29,36,191,203],"fundamental":[5],"role":[6],"in":[7,22],"library":[8],"searching,":[9],"virtual":[10],"screening,":[11],"and":[12,24,74,83,90,131,135],"quantitative":[13],"structure-activity":[14],"relationship/quantitative":[15],"structure-property":[16],"relationship":[17],"modeling":[18],"as":[19,21,35,88,126],"well":[20],"genomics":[23],"proteomics.":[25],"In":[26],"this":[27,178],"paper,":[28],"new":[30,37,94,149],"measure":[32,151,179],"is":[33,101,141,199],"proposed":[34,95],"approach":[38],"for":[39,65,75,163],"the":[40,53,57,77,110,121,145,148,157,161,174,187,197,210],"analysis":[41,168],"of":[42,71,105,123,147,160,177,186],"sequential":[43,72,85],"data,":[44],"where":[45],"useful":[46],"information":[47],"can":[48,62,115],"be":[49,63,116],"also":[50,171],"obtained":[51,195],"by":[52],"ordering":[54],"relationships":[55],"between":[56,79,103],"sequence":[58],"elements.":[59],"This":[60],"methodology":[61],"applied":[64],"evaluating":[66,76],"molecular":[67],"similarity/diversity,":[68],"using":[69],"sets":[70],"descriptors,":[73],"similarity":[78,134],"spectra,":[80],"sensor":[81],"arrays,":[82],"other":[84],"data":[86],"such":[87],"DNA":[89,153,188],"protein":[91],"sequences.":[92,189],"distance":[96],"(weighted":[97],"standardized":[98],"Hasse":[99,106,211],"distance)":[100],"evaluated":[102],"pairs":[104],"matrices":[107],"derived":[108,208],"from":[109,156,196,209],"classical":[111],"partial-ordering":[112],"rules.":[113],"It":[114],"naturally":[117],"standardized,":[118],"thus":[119],"allowing":[120],"interpretation":[122],"these":[124],"distances":[125],"absolute":[127],"values":[128],"(e.g.,":[129],"percentage)":[130],"deriving":[132],"simple":[133,139],"correlation":[136],"indices.":[137],"A":[138],"example":[140],"taken":[142,155],"to":[143,180],"highlight":[144],"behavior":[146],"on":[152],"sequences":[154],"first":[158],"exons":[159],"beta-globins":[162],"eight":[164],"different":[165],"species.":[166],"Sensitivity":[167],"has":[169],"been":[170],"performed,":[172],"showing":[173],"high":[175],"capability":[176],"take":[181],"into":[182],"account":[183],"small":[184],"modifications":[185],"Finally,":[190],"comparison":[192,204],"with":[193,202,205],"results":[194],"literature":[198],"given,":[200],"together":[201],"matrix":[206],"invariants":[207],"matrix.":[212]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}