{"id":"https://openalex.org/W2175576837","doi":"https://doi.org/10.1021/ci060057q","title":"Exploration of a Binding Mode of Benzothiazol-2-yl Acetonitrile Pyrimidine Core Based Derivatives as Potent c-Jun N-Terminal Kinase-3 Inhibitors and 3D-QSAR Analyses","display_name":"Exploration of a Binding Mode of Benzothiazol-2-yl Acetonitrile Pyrimidine Core Based Derivatives as Potent c-Jun N-Terminal Kinase-3 Inhibitors and 3D-QSAR Analyses","publication_year":2006,"publication_date":"2006-05-27","ids":{"openalex":"https://openalex.org/W2175576837","doi":"https://doi.org/10.1021/ci060057q","mag":"2175576837","pmid":"https://pubmed.ncbi.nlm.nih.gov/16859308"},"language":"en","primary_location":{"id":"doi:10.1021/ci060057q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci060057q","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057292937","display_name":"Pooja Sharma","orcid":"https://orcid.org/0000-0002-0387-9669"},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pooja Sharma","raw_affiliation_strings":["Drug Design, Development and Molecular Modeling Division, Indian Institute of Chemical Biology (CSIR), 4 Raja S.C.Mullick Road, Jadavpur, Kolkata -700032, India"],"affiliations":[{"raw_affiliation_string":"Drug Design, Development and Molecular Modeling Division, Indian Institute of Chemical Biology (CSIR), 4 Raja S.C.Mullick Road, Jadavpur, Kolkata -700032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052277178","display_name":"Nanda Ghoshal","orcid":null},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nanda Ghoshal","raw_affiliation_strings":["Drug Design, Development and Molecular Modeling Division, Indian Institute of Chemical Biology (CSIR), 4 Raja S.C.Mullick Road, Jadavpur, Kolkata -700032, India"],"affiliations":[{"raw_affiliation_string":"Drug Design, Development and Molecular Modeling Division, Indian Institute of Chemical Biology (CSIR), 4 Raja S.C.Mullick Road, Jadavpur, Kolkata -700032, India","institution_ids":["https://openalex.org/I160344538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057292937"],"corresponding_institution_ids":["https://openalex.org/I160344538"],"apc_list":null,"apc_paid":null,"fwci":2.2892,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88693269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"46","issue":"4","first_page":"1763","last_page":"1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.851139485836029},{"id":"https://openalex.org/keywords/benzothiazole","display_name":"Benzothiazole","score":0.7553130388259888},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6765080094337463},{"id":"https://openalex.org/keywords/pyrimidine","display_name":"Pyrimidine","score":0.5824592709541321},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5432353019714355},{"id":"https://openalex.org/keywords/hydrogen-bond","display_name":"Hydrogen bond","score":0.5247226357460022},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.4494858682155609},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.44294050335884094},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.441465824842453},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.41932281851768494},{"id":"https://openalex.org/keywords/binding-energy","display_name":"Binding energy","score":0.4134785532951355},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3884102702140808},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.3323734700679779},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.2000192105770111},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1967291235923767},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10097706317901611},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09421882033348083},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.07610681653022766}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.851139485836029},{"id":"https://openalex.org/C2777456753","wikidata":"https://www.wikidata.org/wiki/Q419096","display_name":"Benzothiazole","level":2,"score":0.7553130388259888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6765080094337463},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.5824592709541321},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5432353019714355},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5247226357460022},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4494858682155609},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44294050335884094},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.441465824842453},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.41932281851768494},{"id":"https://openalex.org/C93282013","wikidata":"https://www.wikidata.org/wiki/Q420754","display_name":"Binding energy","level":2,"score":0.4134785532951355},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3884102702140808},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3323734700679779},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2000192105770111},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1967291235923767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10097706317901611},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09421882033348083},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07610681653022766},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048057","descriptor_name":"Mitogen-Activated Protein Kinase 10","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048057","descriptor_name":"Mitogen-Activated Protein Kinase 10","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048057","descriptor_name":"Mitogen-Activated Protein Kinase 10","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci060057q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci060057q","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:16859308","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16859308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W623814603","https://openalex.org/W1536214112","https://openalex.org/W1571439140","https://openalex.org/W1650490230","https://openalex.org/W1675859815","https://openalex.org/W1891159913","https://openalex.org/W1972145919","https://openalex.org/W1972861978","https://openalex.org/W1976235475","https://openalex.org/W1980019773","https://openalex.org/W1982481962","https://openalex.org/W1983304433","https://openalex.org/W1990472384","https://openalex.org/W2001319940","https://openalex.org/W2003013566","https://openalex.org/W2003962192","https://openalex.org/W2005051528","https://openalex.org/W2005760858","https://openalex.org/W2011089118","https://openalex.org/W2012658767","https://openalex.org/W2017787122","https://openalex.org/W2026403124","https://openalex.org/W2026951979","https://openalex.org/W2039247765","https://openalex.org/W2043141000","https://openalex.org/W2050214949","https://openalex.org/W2055287694","https://openalex.org/W2058588605","https://openalex.org/W2068196702","https://openalex.org/W2075104267","https://openalex.org/W2076515532","https://openalex.org/W2077880395","https://openalex.org/W2086402424","https://openalex.org/W2087661061","https://openalex.org/W2090451973","https://openalex.org/W2092352937","https://openalex.org/W2110120447","https://openalex.org/W2119807130","https://openalex.org/W2128607364","https://openalex.org/W2132188426","https://openalex.org/W2136391397","https://openalex.org/W2139488506","https://openalex.org/W2159164336","https://openalex.org/W2170507872","https://openalex.org/W2951803487","https://openalex.org/W2953003901","https://openalex.org/W4246214341","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2047888417","https://openalex.org/W3053727054","https://openalex.org/W2376434704","https://openalex.org/W2094358908","https://openalex.org/W4231338039","https://openalex.org/W2951552002","https://openalex.org/W2612435761","https://openalex.org/W2915443922","https://openalex.org/W2143628759","https://openalex.org/W2367356390"],"abstract_inverted_index":{"C-Jun":[0],"N-terminal":[1],"kinase":[2],"(JNK)":[3],"is":[4],"a":[5,73,193],"therapeutic":[6],"target":[7],"for":[8,161,192,204],"inhibitors":[9,50,127],"which":[10],"may":[11],"provide":[12,189],"clinical":[13],"benefit":[14],"in":[15,25,185],"the":[16,46,88,93,96,106,114,120,132,199,205],"pathogenesis":[17],"of":[18,51,62,75,81,91,124,207],"rheumatoid":[19],"arthritis":[20],"(RA)":[21],"as":[22,24],"well":[23],"various":[26],"apoptosis-related":[27],"disorders.":[28,209],"The":[29,166,181],"benzothiazol-2-yl":[30],"acetonitrile":[31],"derivatives,":[32],"recently":[33],"reported":[34],"by":[35],"Pascale":[36],"et":[37],"al.":[38],"(J.":[39],"Med.":[40],"Chem.":[41],"2005,":[42],"48,":[43],"4596-4607),":[44],"are":[45,128],"first":[47],"generation":[48],"JNK":[49],"this":[52,186],"class.":[53],"To":[54],"understand":[55],"inhibitory":[56,116],"mechanisms":[57],"and":[58,67,113,136,147,153,155,159,163,178],"elucidate":[59],"pharmacophoric":[60],"properties":[61],"these":[63,125],"derivatives":[64,201],"molecular":[65],"docking":[66],"3D-QSAR":[68,139,182],"studies":[69],"were":[70,141],"performed":[71],"on":[72,131,198],"set":[74],"44":[76],"compounds.":[77],"Ligand":[78],"Fit":[79],"module":[80],"Cerius2":[82],"(4.9)":[83],"was":[84,169],"employed":[85],"to":[86],"locate":[87],"binding":[89,99,108,122,133],"orientations":[90],"all":[92],"compounds":[94],"within":[95],"JNK-3":[97,203],"ATP":[98],"site.":[100],"A":[101],"good":[102],"correlation":[103],"(r2=0.810)":[104],"between":[105],"calculated":[107],"free":[109],"energies":[110],"(-PMF":[111],"score)":[112],"experimental":[115],"activities":[117],"suggests":[118],"that":[119],"identified":[121],"conformations":[123],"potential":[126],"reliable.":[129],"Based":[130],"conformations,":[134],"robust":[135],"highly":[137],"predictive":[138,156],"models":[140],"developed":[142],"with":[143],"conventional":[144],"r2":[145,151,157],"0.886":[146],"0.802,":[148],"full":[149],"cross-validation":[150],"0.980":[152],"0.788,":[154],"0.965":[158],"0.968":[160],"MFA":[162],"MSA,":[164],"respectively.":[165],"interaction":[167],"mode":[168],"demonstrated":[170],"taking":[171],"into":[172],"consideration":[173],"inhibitor":[174,195],"conformation,":[175],"hydrogen":[176],"bonding,":[177],"electrostatic":[179],"interaction.":[180],"model":[183],"built":[184],"study":[187],"will":[188],"clear":[190],"guidelines":[191],"novel":[194],"design":[196],"based":[197],"benzothiazole":[200],"against":[202],"treatment":[206],"inflammatory":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
