{"id":"https://openalex.org/W2168052206","doi":"https://doi.org/10.1021/ci049884m","title":"ADME Evaluation in Drug Discovery. 5. Correlation of Caco-2 Permeation with Simple Molecular Properties","display_name":"ADME Evaluation in Drug Discovery. 5. Correlation of Caco-2 Permeation with Simple Molecular Properties","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2168052206","doi":"https://doi.org/10.1021/ci049884m","mag":"2168052206","pmid":"https://pubmed.ncbi.nlm.nih.gov/15446816"},"language":"en","primary_location":{"id":"doi:10.1021/ci049884m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci049884m","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028525523","display_name":"Tingjun Hou","orcid":"https://orcid.org/0000-0001-7227-2580"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. J. Hou","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441683","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-6644-7046"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Zhang","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099065","display_name":"Ke Xia","orcid":"https://orcid.org/0000-0001-9699-9901"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"K. Xia","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039021048","display_name":"Xi Qiao","orcid":"https://orcid.org/0000-0002-4427-4260"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. B. Qiao","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100666016","display_name":"Xiaodan Xu","orcid":"https://orcid.org/0000-0003-2876-3774"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. J. Xu","raw_affiliation_strings":["College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005099065"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":7.5228,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.97751764,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"44","issue":"5","first_page":"1585","last_page":"1600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polar-surface-area","display_name":"Polar surface area","score":0.8954340219497681},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7196553945541382},{"id":"https://openalex.org/keywords/permeation","display_name":"Permeation","score":0.7012360095977783},{"id":"https://openalex.org/keywords/radius-of-gyration","display_name":"Radius of gyration","score":0.6325597167015076},{"id":"https://openalex.org/keywords/molecular-descriptor","display_name":"Molecular descriptor","score":0.6188528537750244},{"id":"https://openalex.org/keywords/accessible-surface-area","display_name":"Accessible surface area","score":0.601900041103363},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5822337865829468},{"id":"https://openalex.org/keywords/polar","display_name":"Polar","score":0.5533867478370667},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.48287370800971985},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.4718729853630066},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.3562699258327484},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.3414386212825775},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.29308488965034485},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.17399373650550842},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.14950048923492432},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13908767700195312},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.11802119016647339}],"concepts":[{"id":"https://openalex.org/C207464780","wikidata":"https://www.wikidata.org/wiki/Q7209103","display_name":"Polar surface area","level":3,"score":0.8954340219497681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7196553945541382},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7012360095977783},{"id":"https://openalex.org/C168568712","wikidata":"https://www.wikidata.org/wiki/Q909999","display_name":"Radius of gyration","level":3,"score":0.6325597167015076},{"id":"https://openalex.org/C164923092","wikidata":"https://www.wikidata.org/wiki/Q3705921","display_name":"Molecular descriptor","level":3,"score":0.6188528537750244},{"id":"https://openalex.org/C11072593","wikidata":"https://www.wikidata.org/wiki/Q3622068","display_name":"Accessible surface area","level":2,"score":0.601900041103363},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5822337865829468},{"id":"https://openalex.org/C29705727","wikidata":"https://www.wikidata.org/wiki/Q294562","display_name":"Polar","level":2,"score":0.5533867478370667},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.48287370800971985},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4718729853630066},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3562699258327484},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3414386212825775},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.29308488965034485},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.17399373650550842},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14950048923492432},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13908767700195312},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11802119016647339},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci049884m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci049884m","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:15446816","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15446816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.591.7579","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.591.7579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://modem.ucsd.edu/htjcadd/publications/paper/89.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W48608734","https://openalex.org/W158712663","https://openalex.org/W324557225","https://openalex.org/W1494838316","https://openalex.org/W1520727604","https://openalex.org/W1539261538","https://openalex.org/W1556702215","https://openalex.org/W1574019439","https://openalex.org/W1576191841","https://openalex.org/W1596283370","https://openalex.org/W1976507247","https://openalex.org/W1979196526","https://openalex.org/W1980383217","https://openalex.org/W1981848002","https://openalex.org/W1986780756","https://openalex.org/W1990057891","https://openalex.org/W1991443437","https://openalex.org/W1992673358","https://openalex.org/W1993416723","https://openalex.org/W2008517160","https://openalex.org/W2009899562","https://openalex.org/W2011314519","https://openalex.org/W2011505858","https://openalex.org/W2028273867","https://openalex.org/W2031553055","https://openalex.org/W2033495141","https://openalex.org/W2035830147","https://openalex.org/W2050736612","https://openalex.org/W2053073229","https://openalex.org/W2056894496","https://openalex.org/W2074514736","https://openalex.org/W2084375116","https://openalex.org/W2087661061","https://openalex.org/W2091758060","https://openalex.org/W2107680276","https://openalex.org/W2119839118","https://openalex.org/W2124470932","https://openalex.org/W2127971628","https://openalex.org/W2147421370","https://openalex.org/W2151461419","https://openalex.org/W2154756937","https://openalex.org/W2161723120","https://openalex.org/W2214815166","https://openalex.org/W2470246832","https://openalex.org/W2569058322","https://openalex.org/W4229948187","https://openalex.org/W4293003482"],"related_works":["https://openalex.org/W2148009427","https://openalex.org/W2011587761","https://openalex.org/W1518515965","https://openalex.org/W1978931025","https://openalex.org/W3159291941","https://openalex.org/W2063120953","https://openalex.org/W2753230657","https://openalex.org/W2165637039","https://openalex.org/W2026843845","https://openalex.org/W1831996579"],"abstract_inverted_index":{"The":[0,116,158,175,237,262,282,311],"correlations":[1],"between":[2,111,141],"Caco-2":[3,29,72,99,112,142,156,168],"permeability":[4,100,191],"(logPapp)":[5],"and":[6,54,114,124,144,148,200,300],"molecular":[7,206,212,230],"properties":[8],"have":[9,65],"been":[10],"investigated.":[11,216],"A":[12],"training":[13,298],"set":[14,277,299],"of":[15,56,188,197,210,266,278,296,328,336],"77":[16],"structurally":[17],"diverse":[18,280],"organic":[19],"molecules":[20,159],"was":[21,34,214],"used":[22],"to":[23,36,96,138,166],"construct":[24],"significant":[25],"QSAR":[26,268],"models":[27,181],"for":[28,284,325,330],"cell":[30,73,143],"permeation.":[31],"Cellular":[32],"permeation":[33],"found":[35,224],"depend":[37],"primarily":[38],"upon":[39],"experimental":[40],"distribution":[41],"coefficient":[42],"(logD)":[43],"at":[44],"pH":[45],"=":[46,248,251,254,257,260],"7.4,":[47],"high":[48],"charged":[49],"polar":[50,90,103,127],"surface":[51,91,104,122,128],"area":[52,92,105],"(HCPSA),":[53],"radius":[55],"gyration":[57],"(rgyr).":[58],"Among":[59],"these":[60,204],"three":[61,205],"descriptors,":[62,207],"logD":[63,75,84,147],"may":[64,134,320],"the":[66,139,179,183,189,194,208,218,234,267,285,290,294,297,308,317],"largest":[67],"impact":[68],"on":[69],"diffusion":[70],"through":[71,272],"because":[74,101],"shows":[76],"obvious":[77],"linear":[78,235],"correlation":[79],"with":[80,155,160,172,229,240],"logPapp":[81,329],"(r=0.703)":[82],"when":[83],"is":[85,151],"smaller":[86,173],"than":[87,170,303],"2.0.":[88],"High":[89],"will":[93,106],"be":[94,135,223,321],"unfavorable":[95],"achieve":[97],"good":[98,244,312,323],"higher":[102],"introduce":[107],"stronger":[108],"H-bonding":[109],"interactions":[110,140],"cells":[113],"drugs.":[115,145],"comparison":[117],"among":[118],"HCPSA,":[119,149],"PSA":[120],"(polar":[121],"area),":[123],"TPSA":[125],"(topological":[126],"area)":[129],"implies":[130],"that":[131,225,316],"high-charged":[132],"atoms":[133],"more":[136,164],"important":[137],"Besides":[146,203],"rgyr":[150,162],"also":[152,215],"closely":[153],"connected":[154],"permeabilities.":[157],"larger":[161],"are":[163,288],"difficult":[165],"cross":[167],"monolayers":[169],"those":[171,304],"rgyr.":[174],"descriptors":[176,213,227,242],"included":[177],"in":[178,185],"prediction":[180],"permit":[182],"interpretation":[184],"structural":[186],"terms":[187],"passive":[190],"process,":[192],"evidencing":[193],"main":[195],"role":[196],"lipholiphicity,":[198],"H-bonding,":[199],"bulk":[201],"properties.":[202],"influence":[209],"other":[211],"From":[217],"calculated":[219],"results,":[220],"it":[221],"can":[222,232],"introducing":[226],"concerned":[228],"flexibility":[231],"improve":[233],"correlation.":[236],"resulting":[238],"model":[239,269,309,319],"four":[241],"bears":[243],"statistical":[245],"significance,":[246],"n":[247],"77,":[249],"r":[250],"0.82,":[252],"q":[253],"0.79,":[255],"s":[256],"0.45,":[258],"F":[259],"35.7.":[261],"actual":[263],"predictive":[264,313],"abilities":[265],"were":[270],"validated":[271],"an":[273],"external":[274],"validation":[275],"test":[276],"23":[279],"compounds.":[281],"predictions":[283],"tested":[286],"compounds":[287,295],"as":[289,293],"same":[291],"accuracy":[292],"significantly":[301],"better":[302],"predicted":[305],"by":[306],"using":[307],"reported.":[310],"ability":[314],"suggests":[315],"proposed":[318],"a":[322],"tool":[324],"fast":[326],"screening":[327],"compound":[331],"libraries":[332],"or":[333],"large":[334],"sets":[335],"new":[337],"chemical":[338],"entities":[339],"via":[340],"combinatorial":[341],"chemistry":[342],"synthesis.":[343]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":11}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}