{"id":"https://openalex.org/W2212549032","doi":"https://doi.org/10.1021/ci034209i","title":"Web-Based Tools for Mining the NCI Databases for Anticancer Drug Discovery","display_name":"Web-Based Tools for Mining the NCI Databases for Anticancer Drug Discovery","publication_year":2003,"publication_date":"2003-12-31","ids":{"openalex":"https://openalex.org/W2212549032","doi":"https://doi.org/10.1021/ci034209i","mag":"2212549032","pmid":"https://pubmed.ncbi.nlm.nih.gov/14741034"},"language":"en","primary_location":{"id":"doi:10.1021/ci034209i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci034209i","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043533892","display_name":"Xueliang Fang","orcid":"https://orcid.org/0009-0007-2273-8363"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xueliang Fang","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934"],"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085392012","display_name":"Lei Shao","orcid":"https://orcid.org/0000-0001-7385-9033"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Shao","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934"],"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323467","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0002-5693-5222"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934"],"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073754378","display_name":"Shaomeng Wang","orcid":"https://orcid.org/0000-0002-8782-6950"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaomeng Wang","raw_affiliation_strings":["University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934"],"affiliations":[{"raw_affiliation_string":"University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043533892"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.8269,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.72183548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"44","issue":"1","first_page":"249","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug","display_name":"Anticancer drug","score":0.651732861995697},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5890424251556396},{"id":"https://openalex.org/keywords/erbb","display_name":"ErbB","score":0.5202247500419617},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4811047911643982},{"id":"https://openalex.org/keywords/web-application","display_name":"Web application","score":0.4615599513053894},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4595870077610016},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43567195534706116},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.41275161504745483},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.40659090876579285},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37989047169685364},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37791818380355835},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.32300007343292236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25898393988609314},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.18073192238807678},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.1183733344078064},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0706724226474762}],"concepts":[{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.651732861995697},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5890424251556396},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.5202247500419617},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4811047911643982},{"id":"https://openalex.org/C118643609","wikidata":"https://www.wikidata.org/wiki/Q189210","display_name":"Web application","level":2,"score":0.4615599513053894},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4595870077610016},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43567195534706116},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41275161504745483},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40659090876579285},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37989047169685364},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37791818380355835},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32300007343292236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25898393988609314},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18073192238807678},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.1183733344078064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0706724226474762},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009316","descriptor_name":"National Institutes of Health (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009316","descriptor_name":"National Institutes of Health (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009316","descriptor_name":"National Institutes of Health (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci034209i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci034209i","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:14741034","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14741034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1964321121","https://openalex.org/W1980949045","https://openalex.org/W2002664886","https://openalex.org/W2018843280","https://openalex.org/W2027066498","https://openalex.org/W2049331434","https://openalex.org/W2072970918","https://openalex.org/W2090631504","https://openalex.org/W2097072725","https://openalex.org/W2101245114","https://openalex.org/W2121831273","https://openalex.org/W2130479394","https://openalex.org/W2167395325","https://openalex.org/W2318605753","https://openalex.org/W4232454014","https://openalex.org/W4299847514"],"related_works":["https://openalex.org/W4248817909","https://openalex.org/W4367048510","https://openalex.org/W2374348909","https://openalex.org/W2507552372","https://openalex.org/W3129624046","https://openalex.org/W2149286326","https://openalex.org/W2150984290","https://openalex.org/W2944441714","https://openalex.org/W2129323261","https://openalex.org/W2412072550"],"abstract_inverted_index":{"In":[0,56],"this":[1],"paper,":[2],"we":[3,58],"describe":[4],"the":[5,16,38,46,50,60,65,68,80,83,89,92,96,107,129,154,160],"development":[6],"of":[7,10,67,79,88,102,116,128,133,157],"a":[8,121,134,144],"set":[9],"integrated":[11],"Web-based":[12,72],"tools":[13,75],"for":[14,23,114,120,126],"mining":[15,74],"National":[17],"Cancer":[18],"Institute's":[19],"(NCI)":[20],"anticancer":[21,24,86,94],"databases":[22],"drug":[25],"discovery.":[26],"For":[27],"data":[28,73],"mining,":[29],"three":[30],"different":[31],"correlation":[32,42,54,69,81],"algorithms":[33],"were":[34,137],"implemented,":[35],"which":[36],"included":[37],"commonly":[39],"used":[40],"Pearson's":[41],"algorithm":[43],"available":[44],"from":[45],"NCI's":[47],"COMPARE":[48],"program,":[49],"Spearman's":[51],"and":[52,99,125,147],"Kendall's":[53],"algorithms.":[55],"addition,":[57],"implemented":[59],"p-value":[61],"test":[62],"to":[63,139,148],"evaluate":[64],"significance":[66],"results.":[70],"These":[71],"allow":[76],"robust":[77],"analysis":[78],"between":[82],"in":[84,91,106,159],"vitro":[85],"activity":[87],"drugs":[90],"NCI":[93,108,161],"database,":[95],"protein":[97],"levels":[98,101,156],"mRNA":[100,155],"molecular":[103,123,130],"targets":[104],"(genes)":[105],"60":[109,162],"human":[110],"cancer":[111],"cell":[112,164],"lines":[113],"identification":[115],"potential":[117,150],"lead":[118,145],"compounds":[119],"specific":[122],"target":[124],"study":[127],"mechanism":[131],"action":[132],"drug.":[135],"Examples":[136],"provided":[138],"identify":[140,149],"PKC":[141],"ligands":[142],"using":[143,153],"compound":[146],"ErbB-2":[151,158],"inhibitors":[152],"tumor":[163],"lines.":[165]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
