{"id":"https://openalex.org/W2201642739","doi":"https://doi.org/10.1021/ci034109c","title":"Eigenvalue Analysis of Peroxisome Proliferator-Activated Receptor \u03b3 Agonists","display_name":"Eigenvalue Analysis of Peroxisome Proliferator-Activated Receptor \u03b3 Agonists","publication_year":2003,"publication_date":"2003-11-12","ids":{"openalex":"https://openalex.org/W2201642739","doi":"https://doi.org/10.1021/ci034109c","mag":"2201642739","pmid":"https://pubmed.ncbi.nlm.nih.gov/14741032"},"language":"en","primary_location":{"id":"doi:10.1021/ci034109c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci034109c","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://ir.ipe.ac.cn/handle/122111/4927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063235026","display_name":"Chenzhong Liao","orcid":"https://orcid.org/0000-0001-7080-1768"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenzhong Liao","raw_affiliation_strings":["Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522622","display_name":"Aihua Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aihua Xie","raw_affiliation_strings":["Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102979537","display_name":"Leming Shi","orcid":"https://orcid.org/0000-0002-7143-2033"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leming Shi","raw_affiliation_strings":["Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102165877","display_name":"Jiaju Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaju Zhou","raw_affiliation_strings":["Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325","https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085142395","display_name":"Xianping Lu","orcid":"https://orcid.org/0000-0003-3933-0931"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianping Lu","raw_affiliation_strings":["Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University, Suite C301, P.O. Box 28, Shenzhen, Guangdong 518057, China, and Institute of Process Engineering, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325","https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4335,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.60409559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"44","issue":"1","first_page":"230","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisome-proliferator","display_name":"Peroxisome proliferator","score":0.6978409886360168},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor","display_name":"Peroxisome proliferator-activated receptor","score":0.6603003144264221},{"id":"https://openalex.org/keywords/peroxisome","display_name":"Peroxisome","score":0.6371683478355408},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5409864187240601},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor-gamma","display_name":"Peroxisome proliferator-activated receptor gamma","score":0.5005085468292236},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor-alpha","display_name":"Peroxisome proliferator-activated receptor alpha","score":0.4651452302932739},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42816242575645447},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23548507690429688},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.15693223476409912},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.13535574078559875}],"concepts":[{"id":"https://openalex.org/C2910266098","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator","level":4,"score":0.6978409886360168},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6603003144264221},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.6371683478355408},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5409864187240601},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.5005085468292236},{"id":"https://openalex.org/C188413054","wikidata":"https://www.wikidata.org/wiki/Q18030677","display_name":"Peroxisome proliferator-activated receptor alpha","level":5,"score":0.4651452302932739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42816242575645447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23548507690429688},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.15693223476409912},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.13535574078559875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ci034109c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci034109c","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:14741032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14741032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null},{"id":"pmh:oai:ir.ipe.ac.cn:122111/4927","is_oa":true,"landing_page_url":"http://ir.ipe.ac.cn/handle/122111/4927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400543","display_name":"CAS OpenIR (Chinese Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I19820366","host_organization_name":"Chinese Academy of Sciences","host_organization_lineage":["https://openalex.org/I19820366"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ipe.ac.cn:122111/4927","is_oa":true,"landing_page_url":"http://ir.ipe.ac.cn/handle/122111/4927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400543","display_name":"CAS OpenIR (Chinese Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I19820366","host_organization_name":"Chinese Academy of Sciences","host_organization_lineage":["https://openalex.org/I19820366"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321895","display_name":"Government of Jiangxi Province","ror":"https://ror.org/02fzqav45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W36311596","https://openalex.org/W1524873219","https://openalex.org/W1536679477","https://openalex.org/W1547036528","https://openalex.org/W1564102867","https://openalex.org/W1573940592","https://openalex.org/W1966041739","https://openalex.org/W1977666051","https://openalex.org/W1987652896","https://openalex.org/W1988771765","https://openalex.org/W2001742702","https://openalex.org/W2002851125","https://openalex.org/W2011805684","https://openalex.org/W2012834939","https://openalex.org/W2013262753","https://openalex.org/W2013313091","https://openalex.org/W2018951304","https://openalex.org/W2026610312","https://openalex.org/W2027324370","https://openalex.org/W2042901562","https://openalex.org/W2063060349","https://openalex.org/W2063521013","https://openalex.org/W2063906760","https://openalex.org/W2066092624","https://openalex.org/W2081846665","https://openalex.org/W2113456624","https://openalex.org/W2133093451","https://openalex.org/W2147596285","https://openalex.org/W2165610631","https://openalex.org/W2931814641"],"related_works":["https://openalex.org/W2094095902","https://openalex.org/W2901656332","https://openalex.org/W2321779907","https://openalex.org/W2392645372","https://openalex.org/W4241055785","https://openalex.org/W2316296538","https://openalex.org/W4384651946","https://openalex.org/W4312382564","https://openalex.org/W2140038597","https://openalex.org/W2430669309"],"abstract_inverted_index":{"Eigenvalue":[0],"analysis":[1],"(EVA)":[2],"was":[3],"conducted":[4],"on":[5],"a":[6,62,95,100,115],"series":[7],"of":[8,11,85,121],"potent":[9],"agonists":[10],"peroxisome":[12],"proliferator-activated":[13],"receptor":[14],"gamma":[15],"(PPARgamma).":[16],"Predictive":[17],"EVA":[18],"quantitative":[19],"structure-activity":[20],"relationship":[21],"(QSAR)":[22],"models":[23,58,75,106],"were":[24,59],"established":[25],"using":[26],"the":[27,45,53,80,119],"SYBYL":[28],"package,":[29],"which":[30],"had":[31],"conventional":[32],"r2":[33],"and":[34,42,48,50,89,109],"cross-validated":[35],"coefficient":[36],"(q2)":[37],"values":[38],"up":[39],"to":[40,70],"0.920":[41],"0.587":[43],"for":[44,52,76,87,91,98,107],"AM1":[46,88],"method":[47],"0.863":[49],"0.586":[51],"PM3":[54,92],"method,":[55],"respectively.":[56],"These":[57],"validated":[60],"by":[61,72],"test":[63],"set":[64,94],"containing":[65],"18":[66],"compounds.":[67],"The":[68],"capability":[69],"predict":[71],"these":[73],"two":[74],"PPARgamma":[77],"agonists,":[78],"with":[79],"best":[81],"predictive":[82],"r2pred":[83],"value":[84],"0.614":[86],"0.822":[90],"methods,":[93],"successful":[96],"example":[97],"applying":[99],"similar":[101],"approach":[102],"in":[103,118],"building":[104],"QSAR":[105],"PPARalpha":[108],"-delta":[110],"that":[111],"could":[112],"potentially":[113],"offer":[114],"new":[116],"opportunity":[117],"design":[120],"novel":[122],"PPAR":[123],"modulators.":[124]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2016-06-24T00:00:00"}
