{"id":"https://openalex.org/W2023531582","doi":"https://doi.org/10.1021/ci025585q","title":"Tuning Neural and Fuzzy-Neural Networks for Toxicity Modeling","display_name":"Tuning Neural and Fuzzy-Neural Networks for Toxicity Modeling","publication_year":2003,"publication_date":"2003-01-23","ids":{"openalex":"https://openalex.org/W2023531582","doi":"https://doi.org/10.1021/ci025585q","mag":"2023531582","pmid":"https://pubmed.ncbi.nlm.nih.gov/12653515"},"language":"en","primary_location":{"id":"doi:10.1021/ci025585q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci025585q","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076261549","display_name":"Paolo Mazzatorta","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"P. Mazzatorta","raw_affiliation_strings":["Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058133879","display_name":"Emilio Benfenati","orcid":"https://orcid.org/0000-0002-3976-5989"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Benfenati","raw_affiliation_strings":["Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024942144","display_name":"Daniel Neagu","orcid":"https://orcid.org/0000-0002-7038-106X"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C.-D. Neagu","raw_affiliation_strings":["Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043925430","display_name":"Giuseppina Gini","orcid":"https://orcid.org/0000-0002-0334-420X"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Gini","raw_affiliation_strings":["Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Mario Negri, via Eritrea 62, Milan, Italy, and DEI, Politecnico di Milano, piazza L. da Vinci 32, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076261549"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":2.8366,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.90767937,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"43","issue":"2","first_page":"513","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9251000285148621,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7812532186508179},{"id":"https://openalex.org/keywords/chemical-toxicity","display_name":"Chemical toxicity","score":0.6030982136726379},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5799311399459839},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.566756546497345},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5541149377822876},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.5530392527580261},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.5377533435821533},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.49944519996643066},{"id":"https://openalex.org/keywords/fish-actinopterygii","display_name":"Fish <Actinopterygii>","score":0.4452308416366577},{"id":"https://openalex.org/keywords/computational-intelligence","display_name":"Computational intelligence","score":0.43524619936943054},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2082805037498474},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12010613083839417},{"id":"https://openalex.org/keywords/fishery","display_name":"Fishery","score":0.0626370906829834},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.05981895327568054}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7812532186508179},{"id":"https://openalex.org/C2910804846","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Chemical toxicity","level":3,"score":0.6030982136726379},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5799311399459839},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.566756546497345},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5541149377822876},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.5530392527580261},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.5377533435821533},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49944519996643066},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.4452308416366577},{"id":"https://openalex.org/C139502532","wikidata":"https://www.wikidata.org/wiki/Q1122090","display_name":"Computational intelligence","level":2,"score":0.43524619936943054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2082805037498474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12010613083839417},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0626370906829834},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05981895327568054}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci025585q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci025585q","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:12653515","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12653515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W164050178","https://openalex.org/W167284164","https://openalex.org/W631091927","https://openalex.org/W1533772347","https://openalex.org/W1587493372","https://openalex.org/W1972386919","https://openalex.org/W1979820878","https://openalex.org/W1982595567","https://openalex.org/W1995714280","https://openalex.org/W2002405291","https://openalex.org/W2067941404","https://openalex.org/W2070348614","https://openalex.org/W2101349570","https://openalex.org/W2102544228","https://openalex.org/W2121374748","https://openalex.org/W2126685080","https://openalex.org/W2158996711","https://openalex.org/W2226815083","https://openalex.org/W2593370231","https://openalex.org/W4285719527","https://openalex.org/W4300973708"],"related_works":["https://openalex.org/W2382340815","https://openalex.org/W1972650408","https://openalex.org/W4388154985","https://openalex.org/W340514219","https://openalex.org/W2019776521","https://openalex.org/W4319348388","https://openalex.org/W1488011299","https://openalex.org/W2070980497","https://openalex.org/W4234053226","https://openalex.org/W2068168367"],"abstract_inverted_index":{"The":[0],"need":[1],"for":[2,6,58],"general":[3],"reliable":[4],"models":[5,57],"predicting":[7],"toxicity":[8,62],"has":[9],"led":[10],"to":[11,33,55],"the":[12,24,30,37,60],"use":[13],"of":[14],"artificial":[15],"intelligence.":[16],"We":[17,27],"applied":[18],"neural":[19],"and":[20],"fuzzy-neural":[21],"networks":[22,31],"with":[23],"QSAR":[25],"approach.":[26],"underline":[28],"how":[29],"have":[32],"be":[34],"tuned":[35],"on":[36,49],"data":[38],"sets":[39],"generally":[40],"involved":[41],"in":[42,53,63],"modeling":[43],"toxicity.":[44],"This":[45],"study":[46],"was":[47],"conducted":[48],"562":[50],"organic":[51],"compounds":[52],"order":[54],"establish":[56],"predictive":[59],"acute":[61],"fish.":[64]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}