{"id":"https://openalex.org/W2210058933","doi":"https://doi.org/10.1021/ci0103469","title":"Novel <i>ZE</i>-Isomerism Descriptors Derived from Molecular Topology and Their Application to QSAR Analysis","display_name":"Novel <i>ZE</i>-Isomerism Descriptors Derived from Molecular Topology and Their Application to QSAR Analysis","publication_year":2002,"publication_date":"2002-05-11","ids":{"openalex":"https://openalex.org/W2210058933","doi":"https://doi.org/10.1021/ci0103469","mag":"2210058933","pmid":"https://pubmed.ncbi.nlm.nih.gov/12132878"},"language":"en","primary_location":{"id":"doi:10.1021/ci0103469","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci0103469","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101738138","display_name":"Alexander Golbraikh","orcid":"https://orcid.org/0000-0003-1711-7953"},"institutions":[{"id":"https://openalex.org/I164185940","display_name":"Texas A&M University at Galveston","ror":"https://ror.org/00w0k4e67","country_code":"US","type":"education","lineage":["https://openalex.org/I164185940"]},{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Golbraikh","raw_affiliation_strings":["Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551"],"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551","institution_ids":["https://openalex.org/I164185940","https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044573961","display_name":"Danail Bonchev","orcid":null},"institutions":[{"id":"https://openalex.org/I164185940","display_name":"Texas A&M University at Galveston","ror":"https://ror.org/00w0k4e67","country_code":"US","type":"education","lineage":["https://openalex.org/I164185940"]},{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danail Bonchev","raw_affiliation_strings":["Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551"],"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551","institution_ids":["https://openalex.org/I164185940","https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078536199","display_name":"Alexander Tropsha","orcid":"https://orcid.org/0000-0003-3802-8896"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I164185940","display_name":"Texas A&M University at Galveston","ror":"https://ror.org/00w0k4e67","country_code":"US","type":"education","lineage":["https://openalex.org/I164185940"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Tropsha","raw_affiliation_strings":["Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551"],"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and Program for Theory of Complex Systems, Texas A&M University, Galveston, Fort Crockett Campus, 5007 Avenue U, Galveston, Texas 77551","institution_ids":["https://openalex.org/I164185940","https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101738138"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I164185940"],"apc_list":null,"apc_paid":null,"fwci":3.7264,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.94212282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"4","first_page":"769","last_page":"787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11476","display_name":"Graph theory and applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9602000117301941,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.7869645357131958},{"id":"https://openalex.org/keywords/molecular-descriptor","display_name":"Molecular descriptor","score":0.6502802968025208},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.6223203539848328},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.5174187421798706},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4233097434043884},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.36856260895729065},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3367684483528137},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.31280219554901123},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.25171777606010437}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.7869645357131958},{"id":"https://openalex.org/C164923092","wikidata":"https://www.wikidata.org/wiki/Q3705921","display_name":"Molecular descriptor","level":3,"score":0.6502802968025208},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.6223203539848328},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.5174187421798706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4233097434043884},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.36856260895729065},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3367684483528137},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31280219554901123},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.25171777606010437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci0103469","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci0103469","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:12132878","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12132878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W421463624","https://openalex.org/W1488799823","https://openalex.org/W1516720576","https://openalex.org/W1545231783","https://openalex.org/W1585772109","https://openalex.org/W1970026614","https://openalex.org/W1972045174","https://openalex.org/W1973615440","https://openalex.org/W1976465664","https://openalex.org/W1979859900","https://openalex.org/W1980956598","https://openalex.org/W1986416602","https://openalex.org/W1987749240","https://openalex.org/W1989260418","https://openalex.org/W1990650174","https://openalex.org/W1995875735","https://openalex.org/W1998351517","https://openalex.org/W1998532396","https://openalex.org/W2000628228","https://openalex.org/W2002503643","https://openalex.org/W2008442742","https://openalex.org/W2009591425","https://openalex.org/W2012243051","https://openalex.org/W2021229217","https://openalex.org/W2027815353","https://openalex.org/W2030567092","https://openalex.org/W2032389990","https://openalex.org/W2039054811","https://openalex.org/W2042434161","https://openalex.org/W2046283501","https://openalex.org/W2046551730","https://openalex.org/W2046737049","https://openalex.org/W2049529694","https://openalex.org/W2053278070","https://openalex.org/W2053819629","https://openalex.org/W2057873712","https://openalex.org/W2059504929","https://openalex.org/W2063060349","https://openalex.org/W2067642251","https://openalex.org/W2077156091","https://openalex.org/W2082042907","https://openalex.org/W2084661650","https://openalex.org/W2085908220","https://openalex.org/W2087661061","https://openalex.org/W2088157201","https://openalex.org/W2091056080","https://openalex.org/W2092250250","https://openalex.org/W2093230855","https://openalex.org/W2106630525","https://openalex.org/W2318794083","https://openalex.org/W2322008283","https://openalex.org/W2950292147","https://openalex.org/W2951024884","https://openalex.org/W2993383518","https://openalex.org/W3138618019","https://openalex.org/W4235166168","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2148009427","https://openalex.org/W1518515965","https://openalex.org/W1978931025","https://openalex.org/W3159291941","https://openalex.org/W2063120953","https://openalex.org/W2753230657","https://openalex.org/W2165637039","https://openalex.org/W2026843845","https://openalex.org/W2889092195","https://openalex.org/W4379468083"],"abstract_inverted_index":{"We":[0],"introduce":[1],"several":[2],"series":[3,135],"of":[4,18,31,96,99,109,122,133,136],"novel":[5],"ZE-isomerism":[6,22,68,100,123],"descriptors":[7,15,54,69,101,105,124],"derived":[8],"directly":[9],"from":[10],"two-dimensional":[11],"molecular":[12,72],"topology.":[13],"These":[14,104],"make":[16],"use":[17],"a":[19,134],"quantity":[20],"named":[21],"correction,":[23],"which":[24],"is":[25,44,128],"added":[26],"to":[27,46,113,125],"the":[28,47,107,131],"vertex":[29],"degrees":[30],"atoms":[32],"connected":[33],"by":[34],"double":[35],"bonds":[36],"in":[37,130],"Z":[38,116],"and":[39,82,117],"E":[40,118],"configurations.":[41],"This":[42],"approach":[43],"similar":[45],"one":[48],"described":[49],"previously":[50],"for":[51],"topological":[52,83,111],"chirality":[53],"(Golbraikh,":[55],"A.,":[56],"et":[57],"al.":[58],"J.":[59],"Chem.":[60],"Inf.":[61],"Comput.":[62],"Sci.":[63],"2001,":[64],"41,":[65],"147-158).":[66],"The":[67,120],"include":[70],"modified":[71],"connectivity":[73],"indices,":[74,77],"overall":[75,80],"Zagreb":[76],"extended":[78],"connectivity,":[79,81],"charge":[84],"indices.":[85],"They":[86],"can":[87],"be":[88],"either":[89],"real":[90],"or":[91],"complex":[92],"numbers.":[93],"Mathematical":[94],"properties":[95],"different":[97],"subgroups":[98],"are":[102],"discussed.":[103],"circumvent":[106],"inability":[108],"conventional":[110],"indices":[112],"distinguish":[114],"between":[115],"isomers.":[119],"applicability":[121],"QSAR":[126],"analysis":[127],"demonstrated":[129],"studies":[132],"131":[137],"anticancer":[138],"agents":[139],"inhibiting":[140],"tubulin":[141],"polymerization.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}