{"id":"https://openalex.org/W2050746665","doi":"https://doi.org/10.1021/ci010317y","title":"The \u201cLatent Membrane Permeability\u201d Concept:\u2009 QSPR Analysis of Inter/Intralaboratorically Variable Caco-2 Permeability","display_name":"The \u201cLatent Membrane Permeability\u201d Concept:\u2009 QSPR Analysis of Inter/Intralaboratorically Variable Caco-2 Permeability","publication_year":2002,"publication_date":"2002-02-19","ids":{"openalex":"https://openalex.org/W2050746665","doi":"https://doi.org/10.1021/ci010317y","mag":"2050746665","pmid":"https://pubmed.ncbi.nlm.nih.gov/11911711"},"language":"en","primary_location":{"id":"doi:10.1021/ci010317y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci010317y","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091285288","display_name":"Fumiyoshi Yamashita","orcid":"https://orcid.org/0000-0002-3503-8696"},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Fumiyoshi Yamashita","raw_affiliation_strings":["Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I25998863","https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423922","display_name":"Shin\u2010ichi Fujiwara","orcid":"https://orcid.org/0000-0002-4015-4237"},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi Fujiwara","raw_affiliation_strings":["Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I25998863","https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082694156","display_name":"Mitsuru Hashida","orcid":"https://orcid.org/0000-0001-7383-8080"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Hashida","raw_affiliation_strings":["Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I25998863","https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091285288"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I25998863"],"apc_list":null,"apc_paid":null,"fwci":1.6938,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83760055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"42","issue":"2","first_page":"408","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/permeability","display_name":"Permeability (electromagnetism)","score":0.7962268590927124},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.7132520079612732},{"id":"https://openalex.org/keywords/caco-2","display_name":"Caco-2","score":0.5824768543243408},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.5796311497688293},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.4919118881225586},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"Membrane permeability","score":0.4898979067802429},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.47247880697250366},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"Intestinal permeability","score":0.4256255328655243},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3914766013622284},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3607586622238159},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2075420320034027},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.13583904504776},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.12341862916946411},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.095671147108078}],"concepts":[{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.7962268590927124},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.7132520079612732},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.5824768543243408},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.5796311497688293},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4919118881225586},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.4898979067802429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47247880697250366},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4256255328655243},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3914766013622284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3607586622238159},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2075420320034027},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13583904504776},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.12341862916946411},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.095671147108078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci010317y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci010317y","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:11911711","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11911711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W225048806","https://openalex.org/W1494838316","https://openalex.org/W1520727604","https://openalex.org/W1556702215","https://openalex.org/W1904678284","https://openalex.org/W1979196526","https://openalex.org/W1990057891","https://openalex.org/W1998700502","https://openalex.org/W2070074841","https://openalex.org/W2072027127","https://openalex.org/W2083715780","https://openalex.org/W2117753715","https://openalex.org/W4229948187","https://openalex.org/W4248107770"],"related_works":["https://openalex.org/W2181974544","https://openalex.org/W2883327819","https://openalex.org/W2097952017","https://openalex.org/W2032306860","https://openalex.org/W2623960567","https://openalex.org/W2484920322","https://openalex.org/W2998974936","https://openalex.org/W1983852331","https://openalex.org/W2071464010","https://openalex.org/W2050746665"],"abstract_inverted_index":{"Caco-2":[0,24,50,83],"cell":[1],"monolayers":[2],"grown":[3],"on":[4],"a":[5,35,55],"filter":[6],"support":[7],"are":[8],"the":[9,42,80,96],"most":[10],"widely":[11],"used":[12],"systems":[13],"for":[14,34],"predicting":[15],"intestinal":[16],"absorption.":[17],"However,":[18],"inter-":[19],"and":[20,63,77],"intralaboratory":[21],"variability":[22],"in":[23],"permeability":[25,51,62,84],"makes":[26],"it":[27],"difficult":[28],"to":[29,72,79],"analyze":[30],"any":[31],"QSPR":[32],"relationship":[33,58],"large":[36],"number":[37],"of":[38,82],"compounds.":[39],"We":[40],"proposed":[41],"\"latent":[43,97],"membrane":[44,61,98],"permeability\"":[45,99],"concept,":[46],"assuming":[47],"that":[48,95],"all":[49],"data":[52,85],"sets":[53,86],"share":[54],"hidden,":[56],"common":[57],"between":[59],"their":[60],"physicochemical":[64],"properties.":[65],"An":[66],"iterative":[67],"calculation":[68],"method":[69],"was":[70],"developed":[71],"handle":[73],"this":[74],"conceptual":[75],"approach":[76],"applied":[78],"analysis":[81,93],"from":[87],"different":[88],"sources.":[89],"A":[90],"thorough":[91],"statistical":[92],"revealed":[94],"concept":[100],"be":[101],"reasonable.":[102]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}
