{"id":"https://openalex.org/W2028726078","doi":"https://doi.org/10.1021/ci010245a","title":"Combined MEDV-GA-MLR Method for QSAR of Three Panels of Steroids, Dipeptides, and COX-2 Inhibitors","display_name":"Combined MEDV-GA-MLR Method for QSAR of Three Panels of Steroids, Dipeptides, and COX-2 Inhibitors","publication_year":2002,"publication_date":"2002-04-24","ids":{"openalex":"https://openalex.org/W2028726078","doi":"https://doi.org/10.1021/ci010245a","mag":"2028726078","pmid":"https://pubmed.ncbi.nlm.nih.gov/12086537"},"language":"en","primary_location":{"id":"doi:10.1021/ci010245a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci010245a","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052846612","display_name":"Shu\u2010Shen Liu","orcid":"https://orcid.org/0000-0002-2160-9750"},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shu-Shen Liu","raw_affiliation_strings":["State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100867382","display_name":"Chunsheng Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Sheng Yin","raw_affiliation_strings":["State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103525209","display_name":"Liansheng Wang","orcid":"https://orcid.org/0000-0001-8070-5171"},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian-Sheng Wang","raw_affiliation_strings":["State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science & Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control and Resources Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052846612"],"corresponding_institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"],"apc_list":null,"apc_paid":null,"fwci":1.0381,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.74888042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"42","issue":"3","first_page":"749","last_page":"756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.9329391717910767},{"id":"https://openalex.org/keywords/loo","display_name":"Loo","score":0.6859993934631348},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6180812120437622},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.5611598491668701},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.5454292297363281},{"id":"https://openalex.org/keywords/correlation-coefficient","display_name":"Correlation coefficient","score":0.5231215357780457},{"id":"https://openalex.org/keywords/mean-squared-error","display_name":"Mean squared error","score":0.5160583853721619},{"id":"https://openalex.org/keywords/partial-least-squares-regression","display_name":"Partial least squares regression","score":0.5064674615859985},{"id":"https://openalex.org/keywords/molecular-descriptor","display_name":"Molecular descriptor","score":0.4880160391330719},{"id":"https://openalex.org/keywords/principal-component-regression","display_name":"Principal component regression","score":0.48620954155921936},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.438096284866333},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.2785372734069824},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.22721973061561584}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.9329391717910767},{"id":"https://openalex.org/C125453309","wikidata":"https://www.wikidata.org/wiki/Q3045008","display_name":"Loo","level":3,"score":0.6859993934631348},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6180812120437622},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.5611598491668701},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5454292297363281},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.5231215357780457},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.5160583853721619},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.5064674615859985},{"id":"https://openalex.org/C164923092","wikidata":"https://www.wikidata.org/wiki/Q3705921","display_name":"Molecular descriptor","level":3,"score":0.4880160391330719},{"id":"https://openalex.org/C74887250","wikidata":"https://www.wikidata.org/wiki/Q3455892","display_name":"Principal component regression","level":3,"score":0.48620954155921936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.438096284866333},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2785372734069824},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.22721973061561584}],"mesh":[{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci010245a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci010245a","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:12086537","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12086537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W122375228","https://openalex.org/W343898530","https://openalex.org/W1497256448","https://openalex.org/W1607549418","https://openalex.org/W1987460555","https://openalex.org/W1996253924","https://openalex.org/W1999334142","https://openalex.org/W2001179019","https://openalex.org/W2014837596","https://openalex.org/W2015870870","https://openalex.org/W2042423435","https://openalex.org/W2063060349","https://openalex.org/W2072088140","https://openalex.org/W2075454202","https://openalex.org/W2080653934","https://openalex.org/W2089619661","https://openalex.org/W2102667102","https://openalex.org/W2149083834","https://openalex.org/W2162517024","https://openalex.org/W3023540311","https://openalex.org/W4244971048"],"related_works":["https://openalex.org/W2951860463","https://openalex.org/W2023531555","https://openalex.org/W2468593193","https://openalex.org/W1966115210","https://openalex.org/W2981666789","https://openalex.org/W2013293448","https://openalex.org/W2042294628","https://openalex.org/W3208896298","https://openalex.org/W2762153840","https://openalex.org/W2045015156"],"abstract_inverted_index":{"The":[0,139,170,222],"MEDV-13,":[1],"molecular":[2],"electronegativity":[3],"distance":[4],"vector":[5],"based":[6],"on":[7],"13":[8],"atomic":[9],"types,":[10],"has":[11,224],"at":[12],"best":[13],"91":[14],"descriptors.":[15],"It":[16],"is":[17,54,77,95,137,220,275],"impossible":[18],"to":[19,26,47,58,80,97],"indirectly":[20],"use":[21],"multiple":[22],"linear":[23],"regression":[24,37,42],"(MLR)":[25],"derive":[27],"a":[28,49,73,99,119,207,225,254],"quantitative":[29],"structure-activity":[30],"relationship":[31],"(QSAR)":[32],"model.":[33],"Although":[34],"principal":[35,61],"component":[36],"(PCR)":[38],"or":[39],"partial":[40],"least-squares":[41],"(PLSR)":[43],"can":[44],"be":[45],"employed":[46,79],"develop":[48],"latent":[50],"QSAR":[51,100,121,209,256],"model,":[52],"it":[53],"still":[55],"difficult":[56],"how":[57],"determine":[59],"the":[60,66,70,86,103,107,125,132,146,153,160,177,184,188,213],"components":[62],"(PCs)":[63],"and":[64,106,134,145,159,167,176,187,197,217,232,236,240,248,263,267,271],"depict":[65],"physical":[67],"meaning":[68],"of":[69,85,110,113,131,142,149,173,180,215],"PCs.":[71],"So,":[72],"genetic":[74],"algorithm":[75],"(GA)":[76],"first":[78],"select":[81],"an":[82],"optimal":[83,104],"subset":[84,105,136,219],"descriptors":[87],"from":[88],"original":[89],"MEDV-13":[90],"descriptor":[91],"set.":[92],"Then":[93],"MLR":[94],"utilized":[96],"build":[98],"model":[101,122,210,257],"between":[102,124,152,183,212],"biological":[108],"activities":[109],"three":[111],"sets":[112],"compounds.":[114],"For":[115,200,244],"31":[116],"benchmark":[117],"steroids,":[118],"5-descriptor":[120,135,218],"(M1)":[123],"corticosteroid-binding":[126],"globulin":[127],"(CBG)":[128],"binding":[129,155],"affinity":[130,156],"steroids":[133],"developed.":[138],"root-mean-square":[140,171],"error":[141,172],"estimations":[143,150],"(RMSEE)":[144],"correlation":[147,178],"coefficient":[148,179],"(r)":[151],"CBG":[154],"(BA)":[157],"observed":[158,186],"BA":[161,185,189],"estimated":[162],"by":[163,191],"M1":[164],"are":[165,195],"0.422":[166],"0.9182,":[168],"respectively.":[169,199],"predictions":[174,181],"(RMSEP)":[175],"(q)":[182],"predicted":[190],"leave-one-out":[192],"cross":[193],"validations":[194],"0.504":[196],"0.8818,":[198],"58":[201],"dipeptides":[202],"inhibiting":[203,251],"angiotensin-converting":[204],"enzyme":[205],"(ACE),":[206],"5-variable":[208],"(M2)":[211],"pIC(50)":[214],"peptides":[216],"derived.":[221],"M2":[223],"high":[226],"quality":[227],"with":[228,259],"RMSEE":[229,260],"=":[230,234,238,242,261,265,269,273],"0.339":[231],"r":[233,264],"0.9398":[235],"RMSEP":[237,268],"0.370":[239],"q":[241,272],"0.9280.":[243],"16":[245],"indomethacin":[246],"amides":[247],"esters":[249],"(ImAE)":[250],"cyclooxygenase-2":[252],"(COX-2),":[253],"6-variable":[255],"(M3)":[258],"0.079":[262],"0.9839":[266],"0.151":[270],"0.9413":[274],"built.":[276]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}