{"id":"https://openalex.org/W2037109408","doi":"https://doi.org/10.1021/ci00028a012","title":"CHORTLES: A Method for Representing Oligomeric and Template-Based Mixtures","display_name":"CHORTLES: A Method for Representing Oligomeric and Template-Based Mixtures","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2037109408","doi":"https://doi.org/10.1021/ci00028a012","mag":"2037109408","pmid":"https://pubmed.ncbi.nlm.nih.gov/8522618"},"language":"en","primary_location":{"id":"doi:10.1021/ci00028a012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci00028a012","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020680926","display_name":"Michael A. Siani","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Siani","raw_affiliation_strings":["Chiron Corporation, Emeryville, California 94608, USA","Chiron Corporation, Emeryville, California 94608 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiron Corporation, Emeryville, California 94608, USA","institution_ids":[]},{"raw_affiliation_string":"Chiron Corporation, Emeryville, California 94608 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085218160","display_name":"David Weininger","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Weininger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069577668","display_name":"Craig A. James","orcid":"https://orcid.org/0000-0003-3544-2637"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig A. James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011025384","display_name":"Jeffrey M. Blaney","orcid":"https://orcid.org/0000-0001-9505-552X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey M. Blaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7387,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.93197083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"6","first_page":"1026","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/template","display_name":"Template","score":0.8264233469963074},{"id":"https://openalex.org/keywords/monomer","display_name":"Monomer","score":0.8173862099647522},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.667972207069397},{"id":"https://openalex.org/keywords/hierarchy","display_name":"Hierarchy","score":0.6622185707092285},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5399707555770874},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5286455750465393},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.4906584322452545},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.47939062118530273},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.45360079407691956},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40055036544799805},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33900439739227295},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.2065967321395874},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.13094362616539001},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.11014950275421143},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09479734301567078}],"concepts":[{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.8264233469963074},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.8173862099647522},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.667972207069397},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.6622185707092285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5399707555770874},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5286455750465393},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4906584322452545},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.47939062118530273},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.45360079407691956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40055036544799805},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33900439739227295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2065967321395874},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.13094362616539001},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.11014950275421143},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09479734301567078},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci00028a012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci00028a012","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:8522618","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8522618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2121300814","https://openalex.org/W4231091074","https://openalex.org/W1886613375","https://openalex.org/W4236081792","https://openalex.org/W4250583430","https://openalex.org/W4234406076","https://openalex.org/W2010731026","https://openalex.org/W4311328601","https://openalex.org/W2360893094","https://openalex.org/W4390787808"],"abstract_inverted_index":{"Screening":[0],"mixtures":[1,36,73,84,98],"of":[2,17,32,37,45,96,123],"synthetic":[3],"oligomers":[4,47],"or":[5],"fixed":[6],"templates":[7],"(e.g.,":[8,131],"rings)":[9],"with":[10],"varying":[11],"substituents":[12],"is":[13,22,126],"increasingly":[14],"the":[15,42,100,121],"focus":[16],"drug":[18,86],"discovery":[19,88],"programs.":[20,89],"CHORTLES":[21,55],"designed":[23],"and":[24,30,34,52,76],"implemented":[25],"to":[26,69,74],"facilitate":[27],"representation,":[28],"storage,":[29],"searching":[31,97],"oligomeric":[33],"template-based":[35],"any":[38],"size.":[39],"Building":[40],"upon":[41],"CHUCKLES":[43],"method":[44,66],"representing":[46],"as":[48,79,120],"both":[49],"monomer-based":[50],"sequences":[51],"all-atom":[53],"structures,":[54],"compactly":[56],"represents":[57],"a":[58,70,106,115],"mixture":[59],"without":[60],"explicitly":[61],"enumerating":[62],"individual":[63,77],"molecules.":[64],"This":[65],"lends":[67],"itself":[68],"hierarchy":[71],"relating":[72],"submixtures":[75],"compounds,":[78],"one":[80],"finds":[81],"when":[82],"deconvoluting":[83],"in":[85,114],"lead":[87],"In":[90],"addition,":[91],"we":[92],"describe":[93],"two":[94],"methods":[95],"at":[99],"monomer":[101,124],"level.":[102],"We":[103],"also":[104],"present":[105],"simple":[107],"pictorial":[108],"representation":[109],"for":[110],"describing":[111],"all":[112],"components":[113],"mixture,":[116],"which":[117],"becomes":[118],"essential":[119],"list":[122],"names":[125,130],"expanded":[127],"beyond":[128],"common":[129],"amino":[132],"acids).":[133]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
