{"id":"https://openalex.org/W2022436448","doi":"https://doi.org/10.1021/ci000167b","title":"On Graphical and Numerical Characterization of Proteomics Maps","display_name":"On Graphical and Numerical Characterization of Proteomics Maps","publication_year":2001,"publication_date":"2001-07-14","ids":{"openalex":"https://openalex.org/W2022436448","doi":"https://doi.org/10.1021/ci000167b","mag":"2022436448","pmid":"https://pubmed.ncbi.nlm.nih.gov/11604034"},"language":"en","primary_location":{"id":"doi:10.1021/ci000167b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci000167b","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081252768","display_name":"Milan Randi\u0107","orcid":"https://orcid.org/0000-0002-1169-4701"},"institutions":[{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Milan Randi\u0107","raw_affiliation_strings":["National Institute of Chemistry, Ljubljana, Slovenia"],"affiliations":[{"raw_affiliation_string":"National Institute of Chemistry, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081252768"],"corresponding_institution_ids":["https://openalex.org/I4210152560"],"apc_list":null,"apc_paid":null,"fwci":7.1736,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.97416543,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"41","issue":"5","first_page":"1330","last_page":"1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zigzag","display_name":"Zigzag","score":0.8651258945465088},{"id":"https://openalex.org/keywords/characterization","display_name":"Characterization (materials science)","score":0.6893276572227478},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5598524808883667},{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.5361091494560242},{"id":"https://openalex.org/keywords/euclidean-geometry","display_name":"Euclidean geometry","score":0.5093449354171753},{"id":"https://openalex.org/keywords/basis","display_name":"Basis (linear algebra)","score":0.45835012197494507},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.42499545216560364},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.39836645126342773},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3950355052947998},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.16440075635910034},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10056197643280029}],"concepts":[{"id":"https://openalex.org/C192271897","wikidata":"https://www.wikidata.org/wiki/Q198438","display_name":"Zigzag","level":2,"score":0.8651258945465088},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.6893276572227478},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5598524808883667},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.5361091494560242},{"id":"https://openalex.org/C129782007","wikidata":"https://www.wikidata.org/wiki/Q162886","display_name":"Euclidean geometry","level":2,"score":0.5093449354171753},{"id":"https://openalex.org/C12426560","wikidata":"https://www.wikidata.org/wiki/Q189569","display_name":"Basis (linear algebra)","level":2,"score":0.45835012197494507},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.42499545216560364},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.39836645126342773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3950355052947998},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.16440075635910034},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10056197643280029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci000167b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci000167b","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:11604034","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11604034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1512018280","https://openalex.org/W1977610286","https://openalex.org/W1997981704","https://openalex.org/W2021276449","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2808029097","https://openalex.org/W3035794677","https://openalex.org/W2032417936","https://openalex.org/W2588100896","https://openalex.org/W2152067480","https://openalex.org/W2326117044","https://openalex.org/W135216162","https://openalex.org/W2947454206","https://openalex.org/W2035708325","https://openalex.org/W4243663106"],"abstract_inverted_index":{"We":[0,88],"outlined":[1],"a":[2,34,56,61,73,79,82,106,111],"mathematical":[3,83,122],"approach":[4,28],"suitable":[5],"for":[6,51],"characterization":[7,20,116,160],"of":[8,21,26,33,117,124,132,138,153,161,167,199],"experimental":[9],"data":[10],"given":[11,135],"by":[12,172,193],"2-D":[13,35,95,164,169],"densitograms.":[14],"In":[15,53,63],"particular":[16],"we":[17],"consider":[18],"numerical":[19],"proteomics":[22],"maps.":[23],"The":[24,150],"basis":[25],"our":[27],"is":[29,58,156],"to":[30,99,158,178,196],"order":[31],"\"spots\"":[32],"map":[36,57],"and":[37,76,143],"assign":[38],"them":[39],"unique":[40],"labels":[41],"(that":[42],"in":[43,94,105,185],"general":[44],"will":[45],"depend":[46],"on":[47,128],"the":[48,64,70,130,144,147,162,197,200],"criteria":[49],"used":[50],"ordering).":[52],"this":[54],"way":[55],"\"translated\"":[59],"into":[60,190],"sequence.":[62],"next":[65],"step":[66],"one":[67,177],"associates":[68],"with":[69],"generated":[71],"sequence":[72],"geometrical":[74],"path":[75,80,108],"views":[77],"such":[78],"as":[81,136],"object":[84],"that":[85,109],"needs":[86],"characterization.":[87],"have":[89],"ordered":[90],"spots":[91,142],"representing":[92],"proteins":[93],"gel":[96],"plates":[97],"according":[98],"their":[100],"relative":[101],"intensities":[102],"which":[103,133,182],"results":[104],"zigzag":[107,118,148],"produces":[110],"complicated":[112],"\"fingerprint\"":[113],"pattern.":[114],"Mathematical":[115],"pattern":[119],"follows":[120],"similar":[121],"characterizations":[123],"embedded":[125],"patterns":[126],"based":[127],"matrices,":[129],"elements":[131],"are":[134],"quotients":[137],"Euclidean":[139],"distance":[140,145],"between":[141],"along":[146],"path.":[149],"leading":[151],"eigenvalue":[152],"constructed":[154],"matrices":[155],"taken":[157],"represent":[159],"original":[163],"map.":[165],"Comparison":[166],"different":[168],"maps":[170],"(simulated":[171],"using":[173],"random":[174],"generator)":[175],"allows":[176],"construct":[179],"partial":[180],"order,":[181],"although":[183],"qualitative":[184],"nature":[186],"gives":[187],"some":[188],"insight":[189],"perturbation":[191],"induced":[192],"foreign":[194],"agents":[195],"proteome":[198],"control":[201],"cell.":[202]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}