{"id":"https://openalex.org/W2041488448","doi":"https://doi.org/10.1021/ci0001280","title":"Topology of Membrane Proteins","display_name":"Topology of Membrane Proteins","publication_year":2001,"publication_date":"2001-02-14","ids":{"openalex":"https://openalex.org/W2041488448","doi":"https://doi.org/10.1021/ci0001280","mag":"2041488448","pmid":"https://pubmed.ncbi.nlm.nih.gov/11277724"},"language":"en","primary_location":{"id":"doi:10.1021/ci0001280","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci0001280","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025649527","display_name":"G\u00e1bor Tusn\u00e1dy","orcid":"https://orcid.org/0000-0001-8105-0285"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor E. Tusn\u00e1dy","raw_affiliation_strings":["Institute of Enzymology, BRC, Hungarian Academy of Sciences, Budapest, Hungary, and Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Enzymology, BRC, Hungarian Academy of Sciences, Budapest, Hungary, and Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I7597260","https://openalex.org/I106118109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078144452","display_name":"Istv\u00e1n Simon","orcid":"https://orcid.org/0000-0003-1207-4018"},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Istv\u00e1n Simon","raw_affiliation_strings":["Institute of Enzymology, BRC, Hungarian Academy of Sciences, Budapest, Hungary, and Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Enzymology, BRC, Hungarian Academy of Sciences, Budapest, Hungary, and Department of Biological Physics, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I7597260","https://openalex.org/I106118109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078144452"],"corresponding_institution_ids":["https://openalex.org/I106118109","https://openalex.org/I4210151515","https://openalex.org/I7597260"],"apc_list":null,"apc_paid":null,"fwci":1.8623,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.85057071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"41","issue":"2","first_page":"364","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-topology","display_name":"Membrane topology","score":0.7818330526351929},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.750304102897644},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.7172448039054871},{"id":"https://openalex.org/keywords/integral-membrane-protein","display_name":"Integral membrane protein","score":0.6515181064605713},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.6480477452278137},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.5448401570320129},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5377194285392761},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.5001161098480225},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.469127893447876},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4489351212978363},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.428364634513855},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4129628837108612},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3886144161224365},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.33352041244506836},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.30338987708091736},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2722945213317871},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23504683375358582},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2192712128162384},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.215660959482193},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.06108471751213074}],"concepts":[{"id":"https://openalex.org/C534586","wikidata":"https://www.wikidata.org/wiki/Q6815143","display_name":"Membrane topology","level":4,"score":0.7818330526351929},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.750304102897644},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.7172448039054871},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.6515181064605713},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.6480477452278137},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5448401570320129},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5377194285392761},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5001161098480225},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.469127893447876},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4489351212978363},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.428364634513855},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4129628837108612},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3886144161224365},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33352041244506836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30338987708091736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2722945213317871},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23504683375358582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2192712128162384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.215660959482193},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.06108471751213074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ci0001280","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci0001280","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Computer Sciences","raw_type":"journal-article"},{"id":"pmid:11277724","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11277724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and computer sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.46000000834465027}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320326184","display_name":"Hungarian Science Foundation","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W569224583","https://openalex.org/W596271391","https://openalex.org/W1526754730","https://openalex.org/W1651097399","https://openalex.org/W1975304761","https://openalex.org/W1978650123","https://openalex.org/W1983464528","https://openalex.org/W1993137607","https://openalex.org/W1999048231","https://openalex.org/W2008708467","https://openalex.org/W2026582002","https://openalex.org/W2029653125","https://openalex.org/W2031084895","https://openalex.org/W2059382484","https://openalex.org/W2067248093","https://openalex.org/W2074481137","https://openalex.org/W2075035438","https://openalex.org/W2078122870","https://openalex.org/W2080301705","https://openalex.org/W2089606003","https://openalex.org/W2114083522","https://openalex.org/W2115840790","https://openalex.org/W2117919289","https://openalex.org/W2120684043","https://openalex.org/W2126405180","https://openalex.org/W2144112248","https://openalex.org/W2155147384","https://openalex.org/W2158906453","https://openalex.org/W2159477987","https://openalex.org/W2163137692","https://openalex.org/W2163862717","https://openalex.org/W2165724689","https://openalex.org/W2325744517","https://openalex.org/W4244191430"],"related_works":["https://openalex.org/W251897196","https://openalex.org/W2765661606","https://openalex.org/W2036123216","https://openalex.org/W115706977","https://openalex.org/W2122040451","https://openalex.org/W2012738583","https://openalex.org/W2080468354","https://openalex.org/W2155218490","https://openalex.org/W2046801619","https://openalex.org/W1605593725"],"abstract_inverted_index":{"Integral":[0],"membrane":[1,53],"proteins":[2,54,102],"play":[3],"important":[4,22],"roles":[5],"in":[6,73],"living":[7],"cells.":[8],"Due":[9],"to":[10,43,94],"difficulties":[11],"of":[12,26,29,37,51,61,66,76,89,99],"experimental":[13],"techniques,":[14],"theoretical":[15],"approaches,":[16],"i.e.,":[17],"topology":[18,39,50],"prediction":[19,40,91],"methods,":[20],"are":[21,71],"for":[23],"structure":[24],"determination":[25],"this":[27,44],"class":[28],"proteins.":[30],"Here":[31],"we":[32,46],"show":[33],"a":[34],"detailed":[35],"comparison":[36],"transmembrane":[38,101],"methods.":[41],"According":[42],"comparison,":[45],"conclude":[47],"that":[48],"the":[49,58,62,77,95],"integral":[52],"is":[55],"determined":[56],"by":[57,83],"maximum":[59],"divergence":[60],"amino":[63],"acid":[64],"composition":[65],"sequence":[67],"segments.":[68],"These":[69],"segments":[70],"located":[72],"different":[74,84],"areas":[75],"cell,":[78],"which":[79],"can":[80],"be":[81,105],"characterized":[82],"physicochemical":[85],"properties.":[86],"The":[87],"results":[88],"these":[90],"methods":[92],"compared":[93],"X-ray":[96],"diffraction":[97],"data":[98],"several":[100],"will":[103],"also":[104],"discussed.":[106]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
