{"id":"https://openalex.org/W3042236348","doi":"https://doi.org/10.1021/acs.jcim.9b01134","title":"Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation","display_name":"Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation","publication_year":2020,"publication_date":"2020-07-13","ids":{"openalex":"https://openalex.org/W3042236348","doi":"https://doi.org/10.1021/acs.jcim.9b01134","mag":"3042236348","pmid":"https://pubmed.ncbi.nlm.nih.gov/32659088"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b01134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b01134","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026382818","display_name":"Asma Nazar","orcid":null},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Asma Nazar","raw_affiliation_strings":["Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101597199","display_name":"Ghulam Abbas","orcid":"https://orcid.org/0000-0001-8476-2181"},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ghulam Abbas","raw_affiliation_strings":["Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036929679","display_name":"Syed Sikander Azam","orcid":"https://orcid.org/0000-0001-5624-6120"},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Syed Sikander Azam","raw_affiliation_strings":["Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-5624-6120","affiliations":[{"raw_affiliation_string":"Computational Biology Lab, National Center for Bioinformatics (NCB), Quaid-i-Azam University, Islamabad 45320, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036929679"],"corresponding_institution_ids":["https://openalex.org/I12469534"],"apc_list":null,"apc_paid":null,"fwci":1.0437,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.75016201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"60","issue":"8","first_page":"3812","last_page":"3830"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9742000102996826,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"Hsp90","score":0.750908613204956},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6557643413543701},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5838168263435364},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5581240057945251},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5133001208305359},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.48382845520973206},{"id":"https://openalex.org/keywords/heat-shock-protein","display_name":"Heat shock protein","score":0.48199453949928284},{"id":"https://openalex.org/keywords/hydrogen-bond","display_name":"Hydrogen bond","score":0.4648984968662262},{"id":"https://openalex.org/keywords/hsp90-inhibitor","display_name":"Hsp90 inhibitor","score":0.42748960852622986},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.4240136742591858},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35577619075775146},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35021477937698364},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29184818267822266},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.28289175033569336},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.20833557844161987},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14571750164031982},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.12642303109169006}],"concepts":[{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.750908613204956},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6557643413543701},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5838168263435364},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5581240057945251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5133001208305359},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.48382845520973206},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.48199453949928284},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4648984968662262},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.42748960852622986},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4240136742591858},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35577619075775146},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35021477937698364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29184818267822266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28289175033569336},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20833557844161987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14571750164031982},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12642303109169006},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b01134","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b01134","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:32659088","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32659088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G7687832613","display_name":null,"funder_award_id":"Pak-US/2017/360","funder_id":"https://openalex.org/F4320306115","funder_display_name":"United States Agency for International Development"}],"funders":[{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320326275","display_name":"Higher Education Commision, Pakistan","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W433146902","https://openalex.org/W1511706710","https://openalex.org/W1966238197","https://openalex.org/W1968485536","https://openalex.org/W1968984443","https://openalex.org/W1970715889","https://openalex.org/W1970969449","https://openalex.org/W1973191530","https://openalex.org/W1976813810","https://openalex.org/W1979915001","https://openalex.org/W1988675578","https://openalex.org/W1988703094","https://openalex.org/W1994526004","https://openalex.org/W1997041432","https://openalex.org/W1998228029","https://openalex.org/W2001082974","https://openalex.org/W2001354744","https://openalex.org/W2002044132","https://openalex.org/W2002851265","https://openalex.org/W2003299656","https://openalex.org/W2006357567","https://openalex.org/W2017516497","https://openalex.org/W2019107211","https://openalex.org/W2022531767","https://openalex.org/W2023475143","https://openalex.org/W2027432915","https://openalex.org/W2028658556","https://openalex.org/W2028978816","https://openalex.org/W2029667189","https://openalex.org/W2034930480","https://openalex.org/W2038441129","https://openalex.org/W2043509228","https://openalex.org/W2048587531","https://openalex.org/W2049595905","https://openalex.org/W2050456292","https://openalex.org/W2052701304","https://openalex.org/W2056826506","https://openalex.org/W2060902443","https://openalex.org/W2063956958","https://openalex.org/W2064630223","https://openalex.org/W2069126953","https://openalex.org/W2070787809","https://openalex.org/W2072971622","https://openalex.org/W2083164919","https://openalex.org/W2089813815","https://openalex.org/W2093169681","https://openalex.org/W2093381148","https://openalex.org/W2095145930","https://openalex.org/W2095719702","https://openalex.org/W2100561975","https://openalex.org/W2106064593","https://openalex.org/W2108502796","https://openalex.org/W2112417555","https://openalex.org/W2113184090","https://openalex.org/W2113364934","https://openalex.org/W2117692326","https://openalex.org/W2118290365","https://openalex.org/W2124661838","https://openalex.org/W2125007784","https://openalex.org/W2130779618","https://openalex.org/W2132629607","https://openalex.org/W2140277195","https://openalex.org/W2146462263","https://openalex.org/W2152605045","https://openalex.org/W2154662590","https://openalex.org/W2158397840","https://openalex.org/W2161741457","https://openalex.org/W2165563508","https://openalex.org/W2170209934","https://openalex.org/W2252295447","https://openalex.org/W2266013672","https://openalex.org/W2287264043","https://openalex.org/W2294882517","https://openalex.org/W2325034207","https://openalex.org/W2332712348","https://openalex.org/W2441674845","https://openalex.org/W2468607593","https://openalex.org/W2470101008","https://openalex.org/W2470589852","https://openalex.org/W2510726666","https://openalex.org/W2566859523","https://openalex.org/W2593436234","https://openalex.org/W2732355020","https://openalex.org/W2743487040","https://openalex.org/W2755428803","https://openalex.org/W2793646762","https://openalex.org/W2913876929","https://openalex.org/W2963584667","https://openalex.org/W4248107770"],"related_works":["https://openalex.org/W2387080865","https://openalex.org/W3008425152","https://openalex.org/W2510135606","https://openalex.org/W2004834660","https://openalex.org/W2143657744","https://openalex.org/W2254692507","https://openalex.org/W1965487585","https://openalex.org/W1559186561","https://openalex.org/W2137206941","https://openalex.org/W1966492828"],"abstract_inverted_index":{"Heat":[0],"shock":[1],"protein":[2],"90":[3],"(Hsp90)":[4],"performs":[5],"functions":[6],"in":[7,28],"cellular":[8],"activities":[9],"together":[10],"with":[11,56,92,123,248],"other":[12],"signaling":[13,53],"pathways.":[14],"Hsp90":[15,82,113,160,232,260],"is":[16,200],"evolutionarily":[17],"conserved":[18],"and":[19,31,37,48,67,107,115,142,151,158,189,263],"universally":[20],"articulated":[21],"as":[22,43,97,127,129,265],"a":[23,237],"human":[24],"cancer-causing":[25],"agent":[26],"involved":[27],"lung":[29],"cancer":[30,33,57,86,221],"breast":[32],"followed":[34],"by":[35],"colon":[36],"rectum":[38],"cancers.":[39],"It":[40],"has":[41],"emerged":[42],"an":[44,201,266],"effective":[45],"drug":[46],"candidate,":[47],"inhibition":[49,79],"may":[50],"affect":[51],"several":[52],"pathways":[54],"associated":[55],"spread.":[58],"Therefore,":[59],"in-silico":[60],"approaches,":[61],"molecular":[62,64],"docking,":[63],"dynamics":[65],"simulation,":[66],"binding":[68,154,188],"free":[69],"energy":[70],"calculations":[71],"were":[72,95,118,146,165],"applied":[73],"to":[74,83,120,167],"create":[75],"insights":[76,216],"into":[77,217,241],"the":[78,98,103,132,159,173,187,192,195,210,218,242,249,255],"mechanism":[80],"against":[81,224],"identify":[84],"new":[85,215],"therapeutic":[87,222],"drugs.":[88],"Top-docked":[89],"Hsp90-inhibitor":[90],"complexes":[91,100,150],"their":[93,116],"analogues":[94,117],"selected":[96],"best":[99],"based":[101],"on":[102],"GOLD":[104],"fitness":[105],"score":[106],"orientation.":[108],"The":[109,175],"significant":[110],"interaction":[111,155],"of":[112,144,191,209,220,244,251,257],"inhibitors":[114,157,164,233,261],"observed":[119],"be":[121,236],"bound":[122,163],"active":[124,183],"site":[125,184],"residues":[126,185],"well":[128],"residing":[130],"within":[131],"same":[133],"cavity":[134],"region.":[135],"System":[136],"stability":[137,190],"factors":[138],"RMSD,":[139],"RMSF,":[140],"beta-factor,":[141],"radius":[143],"gyration":[145],"analyzed":[147],"for":[148,254],"top-docked":[149],"ensure":[152],"strong":[153],"between":[156],"cavity.":[161],"Cavity":[162],"found":[166],"retain":[168],"consistent":[169],"hydrogen":[170],"bonding":[171],"during":[172],"simulation.":[174],"radial":[176],"distribution":[177],"function":[178],"(RDF)":[179],"illustrated":[180],"that":[181,229],"interacting":[182],"drive":[186],"inhibitors.":[193],"Similarly,":[194],"axial":[196],"frequency":[197],"distribution,":[198],"which":[199],"indigenously":[202],"developed":[203],"analytical":[204],"tool,":[205],"produced":[206],"noteworthy":[207],"knowledge":[208],"hydrogen-bonding":[211],"pattern.":[212],"Results":[213],"yielded":[214],"design":[219],"drugs":[223],"Hsp90.":[225],"This":[226],"finding":[227],"suggests":[228],"under":[230],"trial":[231],"MPC-3100":[234],"could":[235],"potential":[238,245],"starting":[239],"point":[240],"development":[243],"anticancer":[246,267],"agents":[247],"possibility":[250],"future":[252],"directions":[253],"improvement":[256],"early":[258],"existing":[259],"CNF-2024":[262],"SNX-5422":[264],"agent.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2025-10-10T00:00:00"}
