{"id":"https://openalex.org/W2998259373","doi":"https://doi.org/10.1021/acs.jcim.9b01003","title":"Rational Design and <i>In Vitro</i> Evaluation of Novel Peptides Binding to Neuroligin-1 for Synaptic Targeting","display_name":"Rational Design and <i>In Vitro</i> Evaluation of Novel Peptides Binding to Neuroligin-1 for Synaptic Targeting","publication_year":2019,"publication_date":"2019-12-26","ids":{"openalex":"https://openalex.org/W2998259373","doi":"https://doi.org/10.1021/acs.jcim.9b01003","mag":"2998259373","pmid":"https://pubmed.ncbi.nlm.nih.gov/31876421"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b01003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b01003","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080659932","display_name":"Pilar V\u00e1squez","orcid":null},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pilar V\u00e1squez","raw_affiliation_strings":["Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113739003","display_name":"Felipe Vidal","orcid":null},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Felipe Vidal","raw_affiliation_strings":["Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065360934","display_name":"Josefa Torres","orcid":"https://orcid.org/0009-0003-1179-0669"},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Josefa Torres","raw_affiliation_strings":["Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031532013","display_name":"Ver\u00f3nica A. Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-6783-5657"},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ver\u00f3nica A. Jim\u00e9nez","raw_affiliation_strings":["Departamento de Ciencias Qu\u00edmicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Sede Concepci\u00f3n, Autopista Concepci\u00f3n-Talcahuano 7100, Talcahuano 4300866, Chile"],"raw_orcid":"https://orcid.org/0000-0002-6783-5657","affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Qu\u00edmicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Sede Concepci\u00f3n, Autopista Concepci\u00f3n-Talcahuano 7100, Talcahuano 4300866, Chile","institution_ids":["https://openalex.org/I13897259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075595019","display_name":"Leonardo Guzm\u00e1n","orcid":"https://orcid.org/0000-0001-9596-5494"},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Leonardo Guzm\u00e1n","raw_affiliation_strings":["Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031532013","https://openalex.org/A5075595019"],"corresponding_institution_ids":["https://openalex.org/I13897259","https://openalex.org/I172787465"],"apc_list":null,"apc_paid":null,"fwci":0.0855,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49494281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"60","issue":"2","first_page":"995","last_page":"1004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurexin","display_name":"Neurexin","score":0.7158676385879517},{"id":"https://openalex.org/keywords/neuroligin","display_name":"Neuroligin","score":0.6448765993118286},{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.47475531697273254},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.45574498176574707},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.45309311151504517},{"id":"https://openalex.org/keywords/hek-293-cells","display_name":"HEK 293 cells","score":0.44627413153648376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44459161162376404},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.43674778938293457},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.43185746669769287},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.4275951385498047},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.39178675413131714},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3718164563179016},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.27390486001968384},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.24637502431869507},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2054605782032013}],"concepts":[{"id":"https://openalex.org/C2778162979","wikidata":"https://www.wikidata.org/wiki/Q4316431","display_name":"Neurexin","level":4,"score":0.7158676385879517},{"id":"https://openalex.org/C2779790309","wikidata":"https://www.wikidata.org/wiki/Q4316446","display_name":"Neuroligin","level":4,"score":0.6448765993118286},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.47475531697273254},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.45574498176574707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45309311151504517},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.44627413153648376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44459161162376404},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.43674778938293457},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.43185746669769287},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4275951385498047},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39178675413131714},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3718164563179016},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27390486001968384},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24637502431869507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2054605782032013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b01003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b01003","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31876421","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31876421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.75,"id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G73035955","display_name":null,"funder_award_id":"1170853","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1004448681","https://openalex.org/W1617352969","https://openalex.org/W1966277592","https://openalex.org/W1968984443","https://openalex.org/W1974312192","https://openalex.org/W1988011192","https://openalex.org/W2009356149","https://openalex.org/W2015556634","https://openalex.org/W2029667189","https://openalex.org/W2046165746","https://openalex.org/W2053666202","https://openalex.org/W2077776336","https://openalex.org/W2105668062","https://openalex.org/W2116835533","https://openalex.org/W2134967712","https://openalex.org/W2145003526","https://openalex.org/W2146526204","https://openalex.org/W2149525061","https://openalex.org/W2168639488","https://openalex.org/W2301827213","https://openalex.org/W2579149589","https://openalex.org/W2724823461","https://openalex.org/W2739354616","https://openalex.org/W2794251447","https://openalex.org/W2883873335","https://openalex.org/W2953716731","https://openalex.org/W2970854154","https://openalex.org/W4239631248","https://openalex.org/W4255677297"],"related_works":["https://openalex.org/W2106170163","https://openalex.org/W2063777298","https://openalex.org/W2136203517","https://openalex.org/W2071140745","https://openalex.org/W2023179463","https://openalex.org/W2012574484","https://openalex.org/W2015043293","https://openalex.org/W3151772332","https://openalex.org/W2094930464","https://openalex.org/W2593993808"],"abstract_inverted_index":{"Neuroligin-1":[0],"(NL1)":[1],"is":[2],"a":[3,10,30,140],"postsynaptic":[4],"cell":[5,125],"adhesion":[6,63],"protein":[7,43],"that":[8,113],"plays":[9],"crucial":[11],"role":[12],"in":[13,24,41,59,103,116,124],"synapsis":[14],"and":[15,81],"signaling":[16],"between":[17],"neurons.":[18],"Due":[19],"to":[20,48,88],"its":[21],"clustered":[22],"distribution":[23],"synaptic":[25,35,62],"clefts,":[26],"NL1":[27,56],"appears":[28,138],"as":[29,97,139,151],"novel":[31],"potential":[32],"site":[33],"for":[34,143],"targeting":[36],"purposes.":[37],"In":[38],"this":[39],"work,":[40],"silico":[42],"topography":[44],"analysis":[45],"was":[46,131],"employed":[47],"identify":[49,89],"two":[50],"prospective":[51],"binding":[52,82],"sites":[53],"on":[54],"the":[55,60,117,134,144],"dimer":[57],"surface":[58],"2:2":[61],"complex":[64],"with":[65,93,107],"\u03b2-neurexin":[66],"(PDB":[67],"code":[68],"3B3Q).":[69],"Receptor-based":[70],"rational":[71],"design,":[72],"cell-penetrating":[73,99],"capability":[74,130],"prediction,":[75],"molecular":[76,78],"docking,":[77],"dynamics":[79],"simulations,":[80],"free":[83],"energy":[84],"calculations":[85],"were":[86],"used":[87],"five":[90],"heptapeptides":[91],"candidates":[92],"favorable":[94],"predicted":[95],"profiles":[96],"non":[98],"NL1-binding":[100],"agents.":[101],"Preliminary":[102],"vitro":[104],"colocalization":[105],"assays":[106],"NL1-transfected":[108],"HEK":[109],"293":[110],"cells":[111],"confirmed":[112],"peptides":[114],"remain":[115],"extracellular":[118],"space":[119],"without":[120],"inducing":[121],"detectable":[122],"changes":[123],"morphology.":[126],"The":[127],"highest":[128],"NL1-colocatization":[129],"attained":[132],"by":[133],"peptide":[135],"ADEAIVA,":[136],"which":[137],"promising":[141],"candidate":[142],"future":[145],"development":[146],"of":[147,153],"specific":[148],"NL1-targeting":[149],"systems":[150],"part":[152],"synapse-directed":[154],"therapies":[155],"against":[156],"central":[157],"nervous":[158],"system":[159],"diseases.":[160]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}