{"id":"https://openalex.org/W2989770770","doi":"https://doi.org/10.1021/acs.jcim.9b00904","title":"The Lazy Life of Lipid-Linked Oligosaccharides in All Life Domains","display_name":"The Lazy Life of Lipid-Linked Oligosaccharides in All Life Domains","publication_year":2019,"publication_date":"2019-11-26","ids":{"openalex":"https://openalex.org/W2989770770","doi":"https://doi.org/10.1021/acs.jcim.9b00904","mag":"2989770770","pmid":"https://pubmed.ncbi.nlm.nih.gov/31769974"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00904","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00904","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051123981","display_name":"Pablo R. Arantes","orcid":"https://orcid.org/0000-0003-1946-2750"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I134363262","display_name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre","ror":"https://ror.org/00x0nkm13","country_code":"BR","type":"education","lineage":["https://openalex.org/I134363262"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Pablo R. Arantes","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre \u2212 UFCSPA, Sarmento Leite, 245, Lab.714, Porto Alegre, RS 90050-170, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1946-2750","affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre \u2212 UFCSPA, Sarmento Leite, 245, Lab.714, Porto Alegre, RS 90050-170, Brazil","institution_ids":["https://openalex.org/I134363262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067913606","display_name":"Conrado Pedebos","orcid":"https://orcid.org/0000-0003-0378-4851"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["BR","GB"],"is_corresponding":false,"raw_author_name":"Conrado Pedebos","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","School of Chemistry, University of Southampton, Southampton, SO17 1BJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"School of Chemistry, University of Southampton, Southampton, SO17 1BJ, U.K","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017891381","display_name":"Marcelo D. Pol\u00eato","orcid":"https://orcid.org/0000-0001-9210-690X"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo D. Pol\u00eato","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9210-690X","affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, MG 36570-000, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032190365","display_name":"La\u00e9rcio Pol Fachin","orcid":"https://orcid.org/0000-0002-4621-3031"},"institutions":[{"id":"https://openalex.org/I4210137548","display_name":"Centro Universit\u00e1rio Cesmac","ror":"https://ror.org/03rzfjh59","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210137548"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"La\u00e9rcio Pol-Fachin","raw_affiliation_strings":["Centro Universit\u00e1rio CESMAC, Macei\u00f3, AL 57081-350, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Universit\u00e1rio CESMAC, Macei\u00f3, AL 57081-350, Brazil","institution_ids":["https://openalex.org/I4210137548"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086599258","display_name":"Hugo Verli","orcid":"https://orcid.org/0000-0002-4796-8620"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hugo Verli","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-4796-8620","affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91509-900, Brazil","institution_ids":["https://openalex.org/I130442723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051123981"],"corresponding_institution_ids":["https://openalex.org/I130442723","https://openalex.org/I134363262"],"apc_list":null,"apc_paid":null,"fwci":0.2486,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.560426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"60","issue":"2","first_page":"631","last_page":"643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9645000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dolichol","display_name":"Dolichol","score":0.6831932663917542},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.6040312647819519},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5979976654052734},{"id":"https://openalex.org/keywords/glycan","display_name":"Glycan","score":0.5746283531188965},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.5377914905548096},{"id":"https://openalex.org/keywords/amphiphile","display_name":"Amphiphile","score":0.48024705052375793},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.470491886138916},{"id":"https://openalex.org/keywords/metadynamics","display_name":"Metadynamics","score":0.46665263175964355},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.41193583607673645},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.4006664752960205},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.39951762557029724},{"id":"https://openalex.org/keywords/glycoprotein","display_name":"Glycoprotein","score":0.2953517735004425},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.29226893186569214},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15774458646774292},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.14089840650558472},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.11135643720626831},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.10641294717788696},{"id":"https://openalex.org/keywords/copolymer","display_name":"Copolymer","score":0.08695730566978455}],"concepts":[{"id":"https://openalex.org/C2781446604","wikidata":"https://www.wikidata.org/wiki/Q418203","display_name":"Dolichol","level":4,"score":0.6831932663917542},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6040312647819519},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5979976654052734},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.5746283531188965},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5377914905548096},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.48024705052375793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.470491886138916},{"id":"https://openalex.org/C62752575","wikidata":"https://www.wikidata.org/wiki/Q6822487","display_name":"Metadynamics","level":3,"score":0.46665263175964355},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41193583607673645},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4006664752960205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39951762557029724},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.2953517735004425},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29226893186569214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15774458646774292},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.14089840650558472},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.11135643720626831},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10641294717788696},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.08695730566978455},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jcim.9b00904","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00904","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31769974","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31769974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null},{"id":"pmh:oai:eprints.soton.ac.uk:444249","is_oa":false,"landing_page_url":"http://doi.org/10.1021/acs.jcim.9b00904>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G7830295659","display_name":null,"funder_award_id":"23038.007777/2014-87","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W631195000","https://openalex.org/W1031578623","https://openalex.org/W1931545954","https://openalex.org/W1964462261","https://openalex.org/W1975434365","https://openalex.org/W1978498560","https://openalex.org/W1982055990","https://openalex.org/W1983279838","https://openalex.org/W1991794210","https://openalex.org/W2022487013","https://openalex.org/W2029667189","https://openalex.org/W2032226429","https://openalex.org/W2033319529","https://openalex.org/W2035266068","https://openalex.org/W2041638382","https://openalex.org/W2049475242","https://openalex.org/W2057477511","https://openalex.org/W2057487309","https://openalex.org/W2058938611","https://openalex.org/W2059013803","https://openalex.org/W2067174909","https://openalex.org/W2078703243","https://openalex.org/W2081693079","https://openalex.org/W2083538385","https://openalex.org/W2088221752","https://openalex.org/W2097308265","https://openalex.org/W2107572441","https://openalex.org/W2111354594","https://openalex.org/W2122929451","https://openalex.org/W2123891429","https://openalex.org/W2127324121","https://openalex.org/W2127522551","https://openalex.org/W2128572087","https://openalex.org/W2129232972","https://openalex.org/W2132905138","https://openalex.org/W2146411229","https://openalex.org/W2151460035","https://openalex.org/W2160544821","https://openalex.org/W2161171034","https://openalex.org/W2309952403","https://openalex.org/W2325631398","https://openalex.org/W2330362920","https://openalex.org/W2470594875","https://openalex.org/W2566131830","https://openalex.org/W2765461328","https://openalex.org/W2792177065","https://openalex.org/W2801621570","https://openalex.org/W2899504765","https://openalex.org/W2909866166","https://openalex.org/W2910934368","https://openalex.org/W3099123759"],"related_works":["https://openalex.org/W2599759970","https://openalex.org/W2084270495","https://openalex.org/W2095322990","https://openalex.org/W1997997899","https://openalex.org/W1633592986","https://openalex.org/W2063273024","https://openalex.org/W2066094175","https://openalex.org/W1979607105","https://openalex.org/W4385857439","https://openalex.org/W4388564886"],"abstract_inverted_index":{"Lipid-linked":[0],"oligosaccharides":[1],"(LLOs)":[2],"play":[3],"an":[4,48,238],"important":[5],"role":[6],"in":[7,38,50,133,211],"the":[8,12,22,53,63,155,161,167,180,198,203,205,208,216,230,234],"N-glycosylation":[9],"pathway":[10],"as":[11,97,99,112],"donor":[13],"substrate":[14],"of":[15,26,36,44,55,66,83,143,175,202,218,233],"oligosaccharyltransferases":[16],"(OSTs),":[17],"which":[18,213],"are":[19,149,164,182,190,195],"responsible":[20],"for":[21],"en":[23],"bloc":[24],"transfer":[25],"glycan":[27,147],"chains":[28,148,177],"onto":[29],"a":[30,45],"nascent":[31],"polypeptide.":[32],"The":[33,173],"lipid":[34,157,168],"component":[35],"LLO":[37,78],"both":[39],"eukarya":[40],"and":[41,47,68,92,119,129,140,184,187,200,207],"archaea":[42],"consists":[43],"dolichol,":[46],"undecaprenol":[49],"prokarya,":[51],"whereas":[52],"number":[54],"isoprene":[56],"units":[57],"may":[58,225],"change":[59],"between":[60],"species.":[61],"Given":[62],"potential":[64],"relevance":[65],"LLOs":[67,132,144,210],"their":[69,93,219],"related":[70,188],"enzymes":[71],"to":[72,123,152,237],"diverse":[73],"biotechnological":[74],"applications,":[75],"obtaining":[76],"reliable":[77],"models":[79],"from":[80],"distinct":[81],"domains":[82],"life":[84],"could":[85],"support":[86,215,226],"further":[87],"studies":[88,228],"on":[89,102,229],"complex":[90],"formation":[91],"processing":[94],"by":[95],"OSTs,":[96],"well":[98],"protein":[100],"engineering":[101],"such":[103,111],"systems.":[104],"In":[105],"this":[106],"work,":[107],"molecular":[108,116,137],"modeling":[109],"techniques,":[110],"quantum":[113],"mechanics":[114],"calculations,":[115],"dynamics":[117,138,174,186,201],"simulations,":[118],"metadynamics":[120,141],"were":[121],"employed":[122],"study":[124],"eukaryotic":[125],"(Glc3-Man9-GlcNAc2-PP-Dolichol),":[126],"bacterial":[127],"(Glc1-GalNAc5-Bac1-PP-Undecaprenol),":[128],"archaeal":[130,209],"(Glc1-Man1-Gal1-Man1-Glc1-Gal1-Glc1-P-Dolichol)":[131],"membrane":[134,156,185],"bilayers.":[135],"Microsecond":[136],"simulations":[139],"calculations":[142],"revealed":[145],"that":[146],"more":[150],"prone":[151],"interact":[153],"with":[154,221],"head":[158,170],"groups,":[159],"while":[160],"PP":[162],"linkages":[163],"positioned":[165],"at":[166],"phosphate":[169],"groups":[171],"level.":[172],"isoprenoid":[176],"embedded":[178],"within":[179],"bilayer":[181],"described,":[183],"properties":[189],"also":[191],"investigated.":[192],"Overall,":[193],"there":[194],"similarities":[196],"regarding":[197],"structure":[199],"eukaryotic,":[204],"bacterial,":[206],"bilayers,":[212],"can":[214],"comprehension":[217],"association":[220],"OSTs.":[222],"These":[223],"data":[224],"future":[227],"transferring":[231],"mechanism":[232],"oligosaccharide":[235],"chain":[236],"acceptor":[239],"protein.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}