{"id":"https://openalex.org/W2997765801","doi":"https://doi.org/10.1021/acs.jcim.9b00903","title":"Coevolved Positions Represent Key Functional Properties in the Trypsin-Like Serine Proteases Protein Family","display_name":"Coevolved Positions Represent Key Functional Properties in the Trypsin-Like Serine Proteases Protein Family","publication_year":2020,"publication_date":"2020-01-02","ids":{"openalex":"https://openalex.org/W2997765801","doi":"https://doi.org/10.1021/acs.jcim.9b00903","mag":"2997765801","pmid":"https://pubmed.ncbi.nlm.nih.gov/31895561"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.9b00903","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00903","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057489258","display_name":"Marcelo Querino Lima Afonso","orcid":"https://orcid.org/0000-0002-9966-8187"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Marcelo Querino Lima Afonso","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078826382","display_name":"Neli Fonseca","orcid":"https://orcid.org/0000-0001-6466-8083"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Neli J. da Fonseca","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053480014","display_name":"Lucas Carrijo de Oliveira","orcid":"https://orcid.org/0000-0003-1855-0871"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas Carrijo de Oliveira","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063430399","display_name":"Francisco Pereira Lobo","orcid":"https://orcid.org/0000-0002-9671-9313"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Pereira Lobo","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006296542","display_name":"Lucas Bleicher","orcid":"https://orcid.org/0000-0001-7121-4952"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lucas Bleicher","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901"],"raw_orcid":"https://orcid.org/0000-0001-7121-4952","affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Av. Pres. Ant\u00f4nio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, Brazil 31270-901","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006296542","https://openalex.org/A5057489258"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":null,"apc_paid":null,"fwci":0.7323,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67804766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"60","issue":"2","first_page":"1060","last_page":"1068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zymogen","display_name":"Zymogen","score":0.934350848197937},{"id":"https://openalex.org/keywords/proteases","display_name":"Proteases","score":0.8102210760116577},{"id":"https://openalex.org/keywords/serine","display_name":"Serine","score":0.7720860838890076},{"id":"https://openalex.org/keywords/trypsinogen","display_name":"Trypsinogen","score":0.7225302457809448},{"id":"https://openalex.org/keywords/trypsin","display_name":"Trypsin","score":0.7081910967826843},{"id":"https://openalex.org/keywords/serine-protease","display_name":"Serine protease","score":0.657221794128418},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.6571676731109619},{"id":"https://openalex.org/keywords/catalytic-triad","display_name":"Catalytic triad","score":0.6187540888786316},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5857698321342468},{"id":"https://openalex.org/keywords/residue","display_name":"Residue (chemistry)","score":0.5040082335472107},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.48144763708114624},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.43880727887153625},{"id":"https://openalex.org/keywords/cleavage","display_name":"Cleavage (geology)","score":0.4216436743736267},{"id":"https://openalex.org/keywords/hydrolase","display_name":"Hydrolase","score":0.4192921817302704},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35466814041137695},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.3239097595214844},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13336461782455444}],"concepts":[{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.934350848197937},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8102210760116577},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7720860838890076},{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.7225302457809448},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.7081910967826843},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.657221794128418},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.6571676731109619},{"id":"https://openalex.org/C145770059","wikidata":"https://www.wikidata.org/wiki/Q751908","display_name":"Catalytic triad","level":4,"score":0.6187540888786316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5857698321342468},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5040082335472107},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48144763708114624},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43880727887153625},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4216436743736267},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.4192921817302704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35466814041137695},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.3239097595214844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13336461782455444},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jcim.9b00903","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00903","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},{"id":"pmid:31895561","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31895561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemical information and modeling","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1556223335","display_name":null,"funder_award_id":"457851/2014-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6074959722","display_name":null,"funder_award_id":"051/2013","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1914281479","https://openalex.org/W1978123763","https://openalex.org/W1979643653","https://openalex.org/W1994734536","https://openalex.org/W1998761138","https://openalex.org/W2003231920","https://openalex.org/W2004091546","https://openalex.org/W2004613702","https://openalex.org/W2006731324","https://openalex.org/W2007037491","https://openalex.org/W2010020730","https://openalex.org/W2011541618","https://openalex.org/W2017197656","https://openalex.org/W2019182985","https://openalex.org/W2020106188","https://openalex.org/W2023297908","https://openalex.org/W2026757390","https://openalex.org/W2027151401","https://openalex.org/W2029667189","https://openalex.org/W2033883576","https://openalex.org/W2037160125","https://openalex.org/W2041856646","https://openalex.org/W2045538255","https://openalex.org/W2047288355","https://openalex.org/W2051126790","https://openalex.org/W2056919550","https://openalex.org/W2057031799","https://openalex.org/W2058241702","https://openalex.org/W2058966982","https://openalex.org/W2062819748","https://openalex.org/W2063599549","https://openalex.org/W2066807950","https://openalex.org/W2075000980","https://openalex.org/W2078144770","https://openalex.org/W2079444915","https://openalex.org/W2082426443","https://openalex.org/W2082573867","https://openalex.org/W2084527777","https://openalex.org/W2086179867","https://openalex.org/W2086978190","https://openalex.org/W2091784724","https://openalex.org/W2092019449","https://openalex.org/W2093482892","https://openalex.org/W2097693498","https://openalex.org/W2103808515","https://openalex.org/W2108441660","https://openalex.org/W2112493206","https://openalex.org/W2117677427","https://openalex.org/W2124210515","https://openalex.org/W2130537614","https://openalex.org/W2139264864","https://openalex.org/W2153207100","https://openalex.org/W2153305301","https://openalex.org/W2154319440","https://openalex.org/W2157222155","https://openalex.org/W2159675211","https://openalex.org/W2159886075","https://openalex.org/W2171603856","https://openalex.org/W2224056471","https://openalex.org/W2512822707","https://openalex.org/W2594207903","https://openalex.org/W2611757667","https://openalex.org/W2752317164","https://openalex.org/W2803038314","https://openalex.org/W2946082766","https://openalex.org/W3151141817","https://openalex.org/W3187441563","https://openalex.org/W4235374480"],"related_works":["https://openalex.org/W2021628134","https://openalex.org/W2128725341","https://openalex.org/W2035606101","https://openalex.org/W1991209896","https://openalex.org/W2102618304","https://openalex.org/W2089385086","https://openalex.org/W1437204455","https://openalex.org/W2512532761","https://openalex.org/W1672939180","https://openalex.org/W2997765801"],"abstract_inverted_index":{"Trypsin-like":[0],"serine":[1],"proteases":[2],"are":[3],"a":[4,46],"group":[5],"of":[6,21,38,45,50,55,58,68,79,88,93,110,135,137],"homologous":[7],"enzymes":[8,23],"which":[9],"exert":[10],"multiple":[11],"roles":[12],"in":[13,40],"both":[14],"vertebrate":[15],"and":[16,52,107,117,131],"invertebrate":[17],"organisms.":[18],"Key":[19],"properties":[20],"these":[22,94,143],"include":[24],"their":[25,33,41],"activation":[26,129],"from":[27],"an":[28],"inactive":[29],"zymogen":[30,99,128],"form":[31,35],"to":[32,85,91,98],"active":[34],"by":[36],"cleavage":[37,63],"residues":[39,89,121,141],"N-terminus,":[42],"the":[43,53,65,77,108,114,127,133,138],"presence":[44],"conserved":[47],"catalytic":[48],"triad":[49],"residues,":[51],"existence":[54],"different":[56],"patterns":[57],"substrate":[59],"selectivity":[60],"for":[61,125],"residue":[62,80],"between":[64,113],"various":[66],"members":[67],"this":[69,73],"protein":[70],"family.":[71],"In":[72],"article,":[74],"we":[75],"apply":[76],"decomposition":[78],"coevolution":[81],"networks":[82],"computational":[83],"method":[84],"find":[86],"sets":[87],"related":[90],"some":[92,136],"key":[95],"properties,":[96],"especially":[97],"activation.":[100],"Positive":[101],"selection":[102],"detection,":[103],"normal":[104],"modes":[105],"analysis,":[106],"calculation":[109],"thermal":[111],"couplings":[112],"bovine":[115,118],"trypsinogen":[116],"trypsin":[119],"structures":[120],"yielded":[122],"further":[123],"information":[124],"understanding":[126],"process":[130],"highlighted":[132],"importance":[134],"coevolved":[139],"set":[140],"during":[142],"transitions.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
